ZA984637B - Spiro-quinuclidine derivatives their preparation and use - Google Patents
Spiro-quinuclidine derivatives their preparation and useInfo
- Publication number
- ZA984637B ZA984637B ZA984637A ZA984637A ZA984637B ZA 984637 B ZA984637 B ZA 984637B ZA 984637 A ZA984637 A ZA 984637A ZA 984637 A ZA984637 A ZA 984637A ZA 984637 B ZA984637 B ZA 984637B
- Authority
- ZA
- South Africa
- Prior art keywords
- spiro
- preparation
- quinuclidine derivatives
- compounds
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK62697 | 1997-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA984637B true ZA984637B (en) | 1998-12-21 |
Family
ID=8095721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA984637A ZA984637B (en) | 1997-05-30 | 1998-05-29 | Spiro-quinuclidine derivatives their preparation and use |
Country Status (11)
Country | Link |
---|---|
US (1) | US6352995B1 (de) |
EP (1) | EP0984970B1 (de) |
JP (1) | JP2002500652A (de) |
CN (1) | CN1110499C (de) |
AT (1) | ATE254618T1 (de) |
AU (1) | AU744368B2 (de) |
CA (1) | CA2289578A1 (de) |
DE (1) | DE69819891T2 (de) |
NZ (1) | NZ500643A (de) |
WO (1) | WO1998054189A1 (de) |
ZA (1) | ZA984637B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2790474B1 (fr) * | 1999-03-05 | 2001-04-06 | Synthelabo | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002016355A2 (en) * | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands |
AU2001284646A1 (en) * | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
ES2280538T3 (es) * | 2001-06-01 | 2007-09-16 | Astrazeneca Ab | Nuevo ligando para receptores nicotinicos de acetilcolina utiles en terapia. |
US6569865B2 (en) | 2001-06-01 | 2003-05-27 | Astrazeneca Ab | Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine |
MXPA04004464A (es) | 2001-11-08 | 2004-08-11 | Upjohn Co | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. |
WO2004013137A1 (en) | 2002-08-01 | 2004-02-12 | Pharmacia & Upjohn Company Llc | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
US20050137217A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | Spirocyclic quinuclidinic ether derivatives |
US7045530B2 (en) | 2003-12-22 | 2006-05-16 | Abbott Laboratories | Spirocyclic quinuclidinic ether derivatives |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
EP1802258A4 (de) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | Biosynchrone transdermale arzneiabgabe |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
CN101772346B (zh) | 2007-04-02 | 2014-05-07 | 帕金森氏病研究院 | 用于降低治疗副作用的方法和组合物 |
JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 薬剤送達方法及びシステム |
US11285306B2 (en) | 2017-01-06 | 2022-03-29 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
EP3801732A4 (de) | 2018-05-29 | 2022-04-27 | Morningside Venture Investments Limited | Verfahren und systeme zur wirkstofffreisetzung |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL48452A (en) | 1975-11-11 | 1979-07-25 | Purdue Frederick Co | Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them |
IL87234A (en) | 1987-08-13 | 1992-02-16 | Israel Inst Biolog Res | Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them |
ATE122353T1 (de) | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Heterozyklische spiroverbindungen und ihre herstellung. |
US4876260A (en) | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
GB8816299D0 (en) * | 1988-07-08 | 1988-08-10 | Merck Sharp & Dohme | Therapeutic agents |
US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
US5803081A (en) * | 1996-06-28 | 1998-09-08 | Regent Court Technologies | Tobacco and related products |
AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
-
1998
- 1998-05-29 AU AU74263/98A patent/AU744368B2/en not_active Ceased
- 1998-05-29 DE DE69819891T patent/DE69819891T2/de not_active Expired - Lifetime
- 1998-05-29 ZA ZA984637A patent/ZA984637B/xx unknown
- 1998-05-29 CA CA002289578A patent/CA2289578A1/en not_active Abandoned
- 1998-05-29 JP JP50013299A patent/JP2002500652A/ja not_active Withdrawn
- 1998-05-29 CN CN98805414A patent/CN1110499C/zh not_active Expired - Fee Related
- 1998-05-29 WO PCT/DK1998/000227 patent/WO1998054189A1/en active IP Right Grant
- 1998-05-29 NZ NZ500643A patent/NZ500643A/en unknown
- 1998-05-29 AT AT98921380T patent/ATE254618T1/de not_active IP Right Cessation
- 1998-05-29 EP EP98921380A patent/EP0984970B1/de not_active Expired - Lifetime
-
1999
- 1999-10-14 US US09/417,889 patent/US6352995B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1257506A (zh) | 2000-06-21 |
AU7426398A (en) | 1998-12-30 |
EP0984970A1 (de) | 2000-03-15 |
DE69819891D1 (de) | 2003-12-24 |
JP2002500652A (ja) | 2002-01-08 |
CA2289578A1 (en) | 1998-12-03 |
AU744368B2 (en) | 2002-02-21 |
ATE254618T1 (de) | 2003-12-15 |
NZ500643A (en) | 2001-12-21 |
CN1110499C (zh) | 2003-06-04 |
EP0984970B1 (de) | 2003-11-19 |
DE69819891T2 (de) | 2004-08-26 |
US6352995B1 (en) | 2002-03-05 |
WO1998054189A1 (en) | 1998-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA984637B (en) | Spiro-quinuclidine derivatives their preparation and use | |
DK0658548T3 (da) | Benzensylfonamidderivat og fremgangsmåde til fremstilling deraf | |
ES2117795T3 (es) | Derivados de acetamida y su uso como modificadores del comportamiento de toma alimentaria. | |
DK0984966T3 (da) | 9-azabicyclo[3.3.1]non-2-en derivater, som er cholinerge ligander på nikotin-ACh receptorer | |
MY117896A (en) | Quinazoline derivatives | |
NO994452D0 (no) | Substituerte 4-arylmetylen-2-imino-2,3-dihydrotiazoler og derivater, og deres farmasöytiske anvendelse | |
ME00459B (me) | Aril fuzirana azapoliciklična jedinjenja | |
CA2269994A1 (en) | 7-hetero-bicyclo¬2.2.1|-heptanes | |
CA2160444A1 (en) | Aroyl-piperdine derivatives | |
NZ308619A (en) | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | |
HUP0003309A2 (hu) | Imidazolilcsoportot tartalmazó gyűrűs acetálok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
HUP0001062A2 (hu) | NAALADáz gátló hatású foszfinsavszármazékokat tartalmazó gyógyászati készítmények | |
FR2712591B1 (fr) | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. | |
PT824530E (pt) | Derivados de arilglicinamida, processos para a sua producao e preparacoes farmaceuticas contendo estes compostos | |
NO963850L (no) | Heterosykliske forbindelser, deres fremstilling og anvendelse | |
HK1032234A1 (en) | Azaring-ether derivatives and their use as nicotinic ach receptor modulators. | |
BG105013A (en) | Heterocyclic ring compounds containing multiple heteroatom, substituted by carboxylic acids, and their isosteres | |
DE69810107D1 (de) | Azacyclooktan- und heptan-derivate, ihre herstellung und ihre therapeutische verwendung | |
HUP0300177A2 (hu) | Szívszélhűdés ellen alkalmazható piridazinil-fenil-hidrazon-származékok és ezeket tartalmazó gyógyszerkészítmények | |
NO973441L (no) | Substituerte fenylforbindelser som endotelinantagonister | |
ES8609307A1 (es) | 1,4-dihidropiridinas | |
EP0801062A4 (de) | Pyrimidin-derivate | |
DE69318715D1 (de) | Pharmakologisch aktive alpha-(tertiär-aminoethyl)-phenylmethanol-derivate | |
SE9401965D0 (sv) | New compounds | |
AU7932000A (en) | N-substituted 1-(lactone) isoquinolones for treating nervous disorders |