ZA984174B - Novel triptolide derivatives useful in the treatment of autoimmune diseases - Google Patents

Novel triptolide derivatives useful in the treatment of autoimmune diseases

Info

Publication number
ZA984174B
ZA984174B ZA984174A ZA984174A ZA984174B ZA 984174 B ZA984174 B ZA 984174B ZA 984174 A ZA984174 A ZA 984174A ZA 984174 A ZA984174 A ZA 984174A ZA 984174 B ZA984174 B ZA 984174B
Authority
ZA
South Africa
Prior art keywords
treatment
autoimmune diseases
derivatives useful
triptolide derivatives
novel triptolide
Prior art date
Application number
ZA984174A
Other languages
English (en)
Inventor
Michel J Jung
Michael Hepperle
Mahinda Wickramaratne
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA984174B publication Critical patent/ZA984174B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA984174A 1997-05-23 1998-05-18 Novel triptolide derivatives useful in the treatment of autoimmune diseases ZA984174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86248897A 1997-05-23 1997-05-23

Publications (1)

Publication Number Publication Date
ZA984174B true ZA984174B (en) 1998-11-23

Family

ID=25338616

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA984174A ZA984174B (en) 1997-05-23 1998-05-18 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Country Status (21)

Country Link
EP (1) EP0983275B1 (da)
JP (1) JP2001525851A (da)
KR (1) KR20010012822A (da)
CN (1) CN1257507A (da)
AR (1) AR012723A1 (da)
AT (1) ATE222910T1 (da)
AU (1) AU741917B2 (da)
BR (1) BR9809678A (da)
CA (1) CA2287977A1 (da)
DE (1) DE69807466T2 (da)
DK (1) DK0983275T3 (da)
ES (1) ES2178207T3 (da)
HK (1) HK1026096A1 (da)
HU (1) HUP0003398A3 (da)
IL (1) IL133088A0 (da)
NO (1) NO995723L (da)
NZ (1) NZ500762A (da)
PT (1) PT983275E (da)
TW (1) TW434235B (da)
WO (1) WO1998052951A1 (da)
ZA (1) ZA984174B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
EP1390358A4 (en) * 2001-03-15 2004-06-16 Pharmagenesis Inc AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
EP2468277A1 (en) * 2002-05-31 2012-06-27 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
EP1581208A1 (en) * 2002-12-17 2005-10-05 Pharmagenesis, Inc. Triptolide derivatives as immunomodulator and anticancer agents
CN1223595C (zh) 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
US8048914B2 (en) 2004-02-09 2011-11-01 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from Tripterygium wilfordii
AU2005218610B2 (en) 2004-03-02 2011-08-18 Pharmagenesis, Inc. Triptolide lactone ring derivatives as immunomodulators and anticancer agents
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
JP5653939B2 (ja) * 2009-02-05 2015-01-14 ファーマジェネシス， インコーポレイテッド 抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体
CA2977559C (en) * 2015-10-29 2022-04-12 Hangzhou Weben Pharmaceuticals Inc C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof
CN114716503B (zh) * 2022-03-23 2024-03-12 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种雷公藤氯内酯醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
ATE222910T1 (de) 2002-09-15
CA2287977A1 (en) 1998-11-26
WO1998052951A1 (en) 1998-11-26
NO995723L (no) 2000-01-21
ES2178207T3 (es) 2002-12-16
TW434235B (en) 2001-05-16
AU741917B2 (en) 2001-12-13
DE69807466T2 (de) 2003-04-24
NZ500762A (en) 2001-08-31
AU7260798A (en) 1998-12-11
DK0983275T3 (da) 2002-12-23
JP2001525851A (ja) 2001-12-11
PT983275E (pt) 2003-01-31
KR20010012822A (ko) 2001-02-26
EP0983275A1 (en) 2000-03-08
CN1257507A (zh) 2000-06-21
EP0983275B1 (en) 2002-08-28
HUP0003398A2 (en) 2001-03-28
NO995723D0 (no) 1999-11-22
HK1026096A1 (en) 2000-12-01
BR9809678A (pt) 2000-07-11
DE69807466D1 (de) 2002-10-02
AR012723A1 (es) 2000-11-08
HUP0003398A3 (en) 2001-09-28
IL133088A0 (en) 2001-03-19

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