ZA983395B - Process for the fermentative production of deacylated cephalosporins - Google Patents

Process for the fermentative production of deacylated cephalosporins

Info

Publication number
ZA983395B
ZA983395B ZA983395A ZA983395A ZA983395B ZA 983395 B ZA983395 B ZA 983395B ZA 983395 A ZA983395 A ZA 983395A ZA 983395 A ZA983395 A ZA 983395A ZA 983395 B ZA983395 B ZA 983395B
Authority
ZA
South Africa
Prior art keywords
fermentative production
deacylated
cephalosporins
deacylated cephalosporins
production
Prior art date
Application number
ZA983395A
Other languages
English (en)
Inventor
Maarten Nieboer
Erik De Vroom
Johannes Lugtenburg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA983395B publication Critical patent/ZA983395B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA983395A 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins ZA983395B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201197 1997-04-22

Publications (1)

Publication Number Publication Date
ZA983395B true ZA983395B (en) 1999-01-27

Family

ID=8228237

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983395A ZA983395B (en) 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins

Country Status (17)

Country Link
US (1) US6410259B1 (ru)
EP (1) EP0915988B1 (ru)
JP (1) JP2000512512A (ru)
KR (1) KR20000022109A (ru)
CN (1) CN1145703C (ru)
AT (1) ATE231919T1 (ru)
AU (1) AU7909498A (ru)
BR (1) BR9804854A (ru)
DE (1) DE69811039T2 (ru)
ES (1) ES2191313T3 (ru)
ID (1) ID21520A (ru)
PL (1) PL330760A1 (ru)
PT (1) PT915988E (ru)
RU (1) RU2208643C2 (ru)
SI (1) SI0915988T1 (ru)
WO (1) WO1998048035A1 (ru)
ZA (1) ZA983395B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3042600A (en) * 1998-12-22 2000-07-12 Dsm N.V. Improved (in vivo) production of cephalosporins
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
EP2310488B1 (en) 2008-08-05 2012-09-19 DSM Sinochem Pharmaceuticals Netherlands B.V. Adipoyl-7-adca producing strains
EP2392649A3 (en) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA producing strains
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
HUE035540T2 (en) 2010-06-22 2018-05-02 Dsm Sinochem Pharm Nl Bv Air bubble fermentation process
CN103429596B (zh) 2011-03-03 2016-03-02 中化帝斯曼制药有限公司荷兰公司 青霉素化合物的降解
CN102757999A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 一种用于生产7-氨基头孢烷酸的发酵培养基及其发酵方法
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
PT97116B (pt) 1990-03-23 1998-10-30 Gist Brocades Nv Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
HU219265B (en) 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca, recombinant dna vectors and host cells
CA2168431A1 (en) * 1993-07-30 1995-02-09 Roelof Ary Lans Bovenberg Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3(carboxymethylthio)propionyl-7-adca

Also Published As

Publication number Publication date
ID21520A (id) 1999-06-24
US6410259B1 (en) 2002-06-25
DE69811039T2 (de) 2004-01-22
ES2191313T3 (es) 2003-09-01
PL330760A1 (en) 1999-05-24
AU7909498A (en) 1998-11-13
RU2208643C2 (ru) 2003-07-20
WO1998048035A1 (en) 1998-10-29
EP0915988B1 (en) 2003-01-29
CN1145703C (zh) 2004-04-14
JP2000512512A (ja) 2000-09-26
KR20000022109A (ko) 2000-04-25
BR9804854A (pt) 1999-09-08
EP0915988A1 (en) 1999-05-19
CN1224469A (zh) 1999-07-28
PT915988E (pt) 2003-06-30
ATE231919T1 (de) 2003-02-15
SI0915988T1 (en) 2003-06-30
DE69811039D1 (de) 2003-03-06

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