ZA983394B - Process for the fermentative production of deacylated cephalosporins - Google Patents

Process for the fermentative production of deacylated cephalosporins

Info

Publication number
ZA983394B
ZA983394B ZA983394A ZA983394A ZA983394B ZA 983394 B ZA983394 B ZA 983394B ZA 983394 A ZA983394 A ZA 983394A ZA 983394 A ZA983394 A ZA 983394A ZA 983394 B ZA983394 B ZA 983394B
Authority
ZA
South Africa
Prior art keywords
fermentative production
deacylated
cephalosporins
deacylated cephalosporins
production
Prior art date
Application number
ZA983394A
Other languages
English (en)
Inventor
Maarten Nieboer
Erik De Vroom
Johannis Lugtenberg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA983394B publication Critical patent/ZA983394B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA983394A 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins ZA983394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201196 1997-04-22

Publications (1)

Publication Number Publication Date
ZA983394B true ZA983394B (en) 1998-10-30

Family

ID=8228236

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983394A ZA983394B (en) 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins

Country Status (14)

Country Link
US (1) US6518039B2 (zh)
EP (1) EP0912754B1 (zh)
JP (1) JP2000512511A (zh)
KR (1) KR20000022108A (zh)
CN (2) CN1224468A (zh)
AT (1) ATE278032T1 (zh)
AU (1) AU7648898A (zh)
BR (1) BR9804857A (zh)
DE (1) DE69826604D1 (zh)
PL (1) PL330759A1 (zh)
RU (1) RU2208644C2 (zh)
TW (1) TW565613B (zh)
WO (1) WO1998048034A1 (zh)
ZA (1) ZA983394B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP1104459A1 (en) 1998-08-12 2001-06-06 Maxygen, Inc. Dna shuffling of monooxygenase genes for production of industrial chemicals
JP2002526107A (ja) 1998-10-07 2002-08-20 マキシジェン， インコーポレイテッド マイコトキシンの解毒のための核酸を生成するためのｄｎａシャッフリング
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
EP1062614A1 (en) 1999-01-19 2000-12-27 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides
JP2003524394A (ja) 1999-02-11 2003-08-19 マキシジェン， インコーポレイテッド ハイスループット質量分析法
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
US7094875B2 (en) 2000-06-23 2006-08-22 Maxygen, Inc. Co-stimulatory polypeptides
AU2001268716A1 (en) 2000-06-23 2002-01-08 Maxygen, Inc. Novel chimeric promoters
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
WO2010015627A2 (en) 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Adipoyl-7-adca producing strains
WO2010015624A1 (en) 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Adipoyl-7-adca producing strains
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
CN103003439A (zh) 2010-06-22 2013-03-27 中化帝斯曼制药有限公司荷兰公司 气泡发酵工艺
EP2681224B1 (en) 2011-03-03 2016-06-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Degradation of penicillin compounds
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
US10208755B2 (en) 2014-08-08 2019-02-19 Baker Hughes, A Ge Company, Llc Magnetic coupling for motor drive shaft of electrical submersible pump

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
PT97116B (pt) 1990-03-23 1998-10-30 Gist Brocades Nv Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
DE69434023D1 (de) * 1993-07-30 2004-10-28 Dsm Ip Assets Bv Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA
SK282617B6 (sk) 1993-07-30 2002-10-08 Dsm N. V. Spôsob výroby a izolácie 7-aminodesacetoxycefalosporánovej kyseliny

Also Published As

Publication number Publication date
BR9804857A (pt) 1999-08-24
US6518039B2 (en) 2003-02-11
RU2208644C2 (ru) 2003-07-20
CN1706963A (zh) 2005-12-14
DE69826604D1 (de) 2004-11-04
TW565613B (en) 2003-12-11
EP0912754B1 (en) 2004-09-29
JP2000512511A (ja) 2000-09-26
EP0912754A1 (en) 1999-05-06
US20020037547A1 (en) 2002-03-28
AU7648898A (en) 1998-11-13
CN1224468A (zh) 1999-07-28
ATE278032T1 (de) 2004-10-15
PL330759A1 (en) 1999-05-24
WO1998048034A1 (en) 1998-10-29
KR20000022108A (ko) 2000-04-25

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