ZA978536B - Nucleic acid constructs containing hybrid promoters for use in gene therapy. - Google Patents
Nucleic acid constructs containing hybrid promoters for use in gene therapy.Info
- Publication number
- ZA978536B ZA978536B ZA9708536A ZA978536A ZA978536B ZA 978536 B ZA978536 B ZA 978536B ZA 9708536 A ZA9708536 A ZA 9708536A ZA 978536 A ZA978536 A ZA 978536A ZA 978536 B ZA978536 B ZA 978536B
- Authority
- ZA
- South Africa
- Prior art keywords
- nucleic acid
- gene therapy
- acid constructs
- constructs containing
- hybrid promoters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19639103A DE19639103A1 (de) | 1996-09-24 | 1996-09-24 | Nukleinsäurekonstrukte mit Hybridpromotoren für gentherapeutische Maßnahmen |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA978536B true ZA978536B (en) | 1998-04-17 |
Family
ID=7806676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9708536A ZA978536B (en) | 1996-09-24 | 1997-09-23 | Nucleic acid constructs containing hybrid promoters for use in gene therapy. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6576758B1 (xx) |
EP (1) | EP0848063A3 (xx) |
JP (1) | JPH10108687A (xx) |
KR (1) | KR19980025142A (xx) |
AR (1) | AR008847A1 (xx) |
AU (1) | AU722354B2 (xx) |
BR (1) | BR9704857A (xx) |
CA (1) | CA2211008A1 (xx) |
DE (1) | DE19639103A1 (xx) |
ZA (1) | ZA978536B (xx) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ121599A3 (cs) | 1998-04-09 | 1999-10-13 | Aventis Pharma Deutschland Gmbh | Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu |
DE19831420A1 (de) * | 1998-07-14 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Expressionssysteme enthaltend chimäre Promotoren mit Bindungsstellen für rekombinante Transkriptionsfaktoren |
IL132446A0 (en) * | 1999-10-18 | 2001-03-19 | Genena Ltd | A method for establishing connections between genes |
AU2001237256A1 (en) * | 2000-03-08 | 2001-09-17 | Neurosearch A/S | A method of sensitising endothelial cells to prodrugs |
CA2434543A1 (en) * | 2001-01-12 | 2002-07-18 | Sbarro Institute For Cancer Research And Molecular Medicine | Inhibition of pathological angiogenesis in vivo |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
AU2005282380A1 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
KR20070101227A (ko) | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도 |
WO2008144067A1 (en) * | 2007-05-21 | 2008-11-27 | Board Of Regents, University Of Texas System | Methods and compositions for treatment of cancer using oncolytic rsv activity |
US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69101032T2 (de) | 1990-07-03 | 1994-08-11 | Kuraray Co | Katalysator und Verfahren zur Herstellung von ungesättigten Estern. |
US5654168A (en) * | 1994-07-01 | 1997-08-05 | Basf Aktiengesellschaft | Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units |
US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
EP0705334A1 (en) * | 1993-06-14 | 1996-04-10 | Basf Aktiengesellschaft | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
GB9402857D0 (en) | 1994-02-15 | 1994-04-06 | Isis Innovation | Targeting gene therapy |
DE4429710A1 (de) | 1994-08-22 | 1996-02-29 | Jun Alexander Faller | Verfahren und Vorrichtung zum Umschlagen von Ladung |
WO1996006938A1 (de) | 1994-08-26 | 1996-03-07 | Hoechst Aktiengesellschaft | Gentherapeutische behandlung von gefässerkrankungen durch einen zellspezifischen, zellzyklusabhängigen wirkstoff |
DK0807183T3 (da) | 1994-08-26 | 2001-03-05 | Aventis Pharma Gmbh | Genterapi af sygdomme, der fremkaldes af immunsystemet, ved hjælp af et cellespecifikt aktivt stof, der reguleres af cellec |
GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
DE19524720A1 (de) | 1995-07-12 | 1997-01-16 | Hoechst Ag | Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3" |
US5965440A (en) * | 1995-12-07 | 1999-10-12 | The General Hospital Corporation | Controlled gene product delivery from a regulatable retroviral vector |
DE19605274A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Nukleinsäurekonstrukte für die zellzyklusregulierte Expression von Genen, derartige Konstrukte enthaltende Zellen sowie deren Verwendung zur Herstellung von Heilmitteln |
DE19605279A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung |
WO1997044447A2 (en) * | 1996-05-03 | 1997-11-27 | President And Fellows Of Harvard College | Transcriptional activation system, activators, and uses therefor |
DE19710643A1 (de) * | 1997-03-14 | 1998-09-17 | Hoechst Ag | Der Promotor des cdc25B Genes und seine Verwendung in der Gentherapie |
-
1996
- 1996-09-24 DE DE19639103A patent/DE19639103A1/de not_active Withdrawn
-
1997
- 1997-09-22 AU AU39199/97A patent/AU722354B2/en not_active Ceased
- 1997-09-22 AR ARP970104341A patent/AR008847A1/es not_active Application Discontinuation
- 1997-09-22 CA CA002211008A patent/CA2211008A1/en not_active Abandoned
- 1997-09-23 EP EP97116536A patent/EP0848063A3/en not_active Withdrawn
- 1997-09-23 ZA ZA9708536A patent/ZA978536B/xx unknown
- 1997-09-24 KR KR1019970050043A patent/KR19980025142A/ko not_active Application Discontinuation
- 1997-09-24 JP JP9259005A patent/JPH10108687A/ja active Pending
- 1997-09-24 US US08/936,603 patent/US6576758B1/en not_active Expired - Fee Related
- 1997-09-24 BR BR9704857A patent/BR9704857A/pt not_active IP Right Cessation
-
2003
- 2003-04-07 US US10/407,277 patent/US20030187245A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0848063A2 (en) | 1998-06-17 |
KR19980025142A (ko) | 1998-07-06 |
AR008847A1 (es) | 2000-02-23 |
DE19639103A1 (de) | 1998-03-26 |
BR9704857A (pt) | 1998-10-27 |
US6576758B1 (en) | 2003-06-10 |
EP0848063A3 (en) | 2002-01-02 |
US20030187245A1 (en) | 2003-10-02 |
AU722354B2 (en) | 2000-07-27 |
AU3919997A (en) | 1998-03-26 |
JPH10108687A (ja) | 1998-04-28 |
CA2211008A1 (en) | 1998-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA978536B (en) | Nucleic acid constructs containing hybrid promoters for use in gene therapy. | |
GB9620769D0 (en) | Nucleic acid sequencing | |
IL123172A0 (en) | Dna constructs | |
HK1012398A1 (en) | Phosphonomonoester nucleic acids, methods for their preparation and their use | |
AU7401394A (en) | In vivo nucleic acid hybridization method | |
AU1606897A (en) | Thymidine kinase variants, corresponding nucleic acid sequences and their use in gene therapy | |
HK1000786A1 (en) | Dna constructs for endogenous gene activation and expression modification. | |
AU4065997A (en) | Non-viral vehicles for use in gene transfer | |
EP0744894A4 (en) | SELF-COMPOSING MULTIMERIC NUCLEIC ACID | |
ZA964136B (en) | Catalytic DNA. | |
AU6591798A (en) | Nucleic acid catalysts | |
AU3595493A (en) | Method for nucleic acid hybridization using single-stranded DNA binding protein | |
HUP0001937A3 (en) | Compounds, preparation and use for transferring nucleic acids into cells | |
AU716500B2 (en) | Nucleic acid constructs for the cell cycle-regulated expression of genes, cells containing such constructs and their use for preparing drugs | |
HUP0104681A3 (en) | Human hybrid host cell for mammalian gene expression | |
EP0579360A3 (en) | Gene for a hyperthermophilic alpha-amylase. | |
ZA972837B (en) | Spray-dried microparticles as therapeutic vehicles for use in gene therapy. | |
IL130886A0 (en) | Nucleic acid sequencing | |
ZA973802B (en) | Nucleic acid constructs containing genes encoding transport signals. | |
AU3762699A (en) | (nr-cam) gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors | |
GB9917875D0 (en) | Nucleic acid constructs | |
AU2114899A (en) | Nucleotide expression systems with reduced immunogenicity for use in gene therapy | |
AU2750197A (en) | Dna replication-regulating genes | |
AU3571797A (en) | Nucleic acid molecule for enhancing gene expression | |
AU1029099A (en) | Transfection system for the transfer of nucleic acids into cells |