ZA975675B - Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one - Google Patents

Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one

Info

Publication number
ZA975675B
ZA975675B ZA975675A ZA975675A ZA975675B ZA 975675 B ZA975675 B ZA 975675B ZA 975675 A ZA975675 A ZA 975675A ZA 975675 A ZA975675 A ZA 975675A ZA 975675 B ZA975675 B ZA 975675B
Authority
ZA
South Africa
Prior art keywords
imidazolidin
ethylidene
oxo
derivatives
Prior art date
Application number
ZA975675A
Other languages
English (en)
Inventor
Joseph Peter Lyssikatos
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA975675B publication Critical patent/ZA975675B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA975675A 1996-06-27 1997-09-03 Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one ZA975675B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2069696P 1996-06-27 1996-06-27

Publications (1)

Publication Number Publication Date
ZA975675B true ZA975675B (en) 1998-01-28

Family

ID=21800047

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA975675A ZA975675B (en) 1996-06-27 1997-09-03 Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one

Country Status (13)

Country Link
US (1) US6071935A (de)
EP (1) EP0907649A1 (de)
JP (1) JPH11512750A (de)
AP (1) AP9701039A0 (de)
AU (1) AU2710597A (de)
BR (1) BR9709974A (de)
CA (1) CA2259222A1 (de)
GT (1) GT199700074A (de)
ID (1) ID17053A (de)
MA (1) MA26432A1 (de)
TN (1) TNSN97110A1 (de)
WO (1) WO1997049700A1 (de)
ZA (1) ZA975675B (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09183725A (ja) * 1995-09-01 1997-07-15 Pfizer Inc ガン治療用治療剤
US20030114503A1 (en) * 1997-06-16 2003-06-19 Pfizer Inc. Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the treatment of cancer
JPH11236333A (ja) * 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−4−オン誘導体
EP1006113A1 (de) 1998-12-02 2000-06-07 Pfizer Products Inc. 2-(2-oxo-ethyliden)-imidazolidin-4-one-Derivate und ihre Verwendung zur Inhibierung des abnormalen Zellwachstums
US6174903B1 (en) 1998-12-28 2001-01-16 Pfizer Inc. Imidazolidin-4-one derivatives useful as anticancer agents
CA2432137C (en) 2000-12-19 2010-12-21 Pfizer Products Inc. Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1h-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production
US6995171B2 (en) 2001-06-21 2006-02-07 Agouron Pharmaceuticals, Inc. Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
US6740757B2 (en) 2001-08-29 2004-05-25 Pfizer Inc Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer
CA2478050A1 (en) * 2002-03-01 2003-09-12 Pfizer Inc. Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
WO2004022097A1 (en) * 2002-09-05 2004-03-18 Medimmune, Inc. Methods of preventing or treating cell malignancies by administering cd2 antagonists
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) * 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
CN1747950A (zh) * 2002-12-19 2006-03-15 美国辉瑞有限公司 用于治疗眼病的作为蛋白激酶抑制剂的2-(1h-吲唑-6-基氨基)-苯甲酰胺化合物
ES2391087T3 (es) 2003-04-11 2012-11-21 Medimmune, Llc Anticuerpos de IL-9 recombinantes y usos de los mismos
AU2004286198C1 (en) 2003-08-18 2011-02-24 Medimmune, Llc Humanization of antibodies
US20060228350A1 (en) * 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
DE602004017479D1 (de) * 2003-08-29 2008-12-11 Pfizer Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
JP2007504121A (ja) * 2003-08-29 2007-03-01 ファイザー・インク 新たな抗血管形成剤として有用なナフタレン・カルボキサミド及びその誘導体
GEP20084572B (en) * 2003-12-23 2008-12-25 Pfizer Novel quinoline derivatives
EP1740184A1 (de) * 2004-03-30 2007-01-10 Pfizer Products Incorporated Kombinationen von signalübertragungshemmern
CA2566160C (en) 2004-05-27 2011-01-18 Pfizer Products Inc. Pyrrolopyrimidine derivatives useful in cancer treatment
PL1786785T3 (pl) 2004-08-26 2010-08-31 Pfizer Enancjomerycznie czyste związki aminoheteroarylowe jako kinazy białkowe
RS51601B (en) * 2004-08-26 2011-08-31 Pfizer Inc. PYRAZOLS SUBSTITUTED BY AMINOHETEROARYL UNITS AS PROTEIN KINASE INHIBITORS
EP1786777A1 (de) * 2004-08-26 2007-05-23 Pfizer, Inc. Aminoheteroarylverbindungen als proteintyrosinkinaseinhibitoren
WO2006024628A1 (en) * 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
JP2008518023A (ja) 2004-10-27 2008-05-29 メディミューン,インコーポレーテッド 同族抗原に対する親和性を改変することによる抗体特異性の調節
US20060107555A1 (en) * 2004-11-09 2006-05-25 Curtis Marc D Universal snow plow adapter
JP5153613B2 (ja) 2005-03-18 2013-02-27 メディミューン,エルエルシー 抗体のフレームワーク・シャッフル
AU2006261920A1 (en) 2005-06-23 2007-01-04 Medimmune, Llc Antibody formulations having optimized aggregation and fragmentation profiles
AP2013006963A0 (en) * 2005-09-07 2013-07-31 Amgen Fremont Inc Human monoclonal antibodies to activin receptor-like Kinase-1
DK1926996T3 (da) 2005-09-20 2012-01-23 Osi Pharmaceuticals Llc Biologiske markører, som er prædiktive for anti-cancer-reaktion på insulinlignende vækstfaktor-1-receptorkinasehæmmere
TW200812615A (en) 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
EP2021338A1 (de) 2006-05-09 2009-02-11 Pfizer Products Inc. Cycloalkylaminosäurederivate und pharmazeutische zusammensetzung davon
SG174090A1 (en) 2006-08-21 2011-09-29 Hoffmann La Roche Tumor therapy with an anti-vegf antibody
SG170032A1 (en) 2006-08-28 2011-04-29 Kyowa Hakko Kirin Co Ltd Antagonistic human light-specific human monoclonal antibodies
EP2703007A1 (de) 2007-03-30 2014-03-05 MedImmune, LLC Antikörper mit verminderten Deamidierungsprofilen
CN101932720A (zh) 2007-10-31 2010-12-29 米迪缪尼有限公司 蛋白质支架
JP2012518657A (ja) 2009-02-25 2012-08-16 オーエスアイ・ファーマシューティカルズ,エルエルシー 併用抗癌治療
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
JP2012519282A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
JP2012519281A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
CA2783656A1 (en) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
WO2011109584A2 (en) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
DK2668210T3 (da) 2011-01-26 2020-08-24 Celldex Therapeutics Inc Anti-kit antistoffer og anvendelser deraf
US20120214830A1 (en) 2011-02-22 2012-08-23 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
EP2702173A1 (de) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Verwendung von emt-gensignaturen bei der entdeckung von krebswirkstoffen, -diagnostika und -behandlungen
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
JP6307075B2 (ja) 2012-07-25 2018-04-18 セルデックス セラピューティクス,インコーポレーテッド 抗kit抗体及びその使用
SG11201502757QA (en) 2012-10-09 2015-05-28 Igenica Biotherapeutics Inc Anti-c16orf54 antibodies and methods of use thereof
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
NZ714765A (en) 2013-06-06 2021-12-24 Pf Medicament Anti-c10orf54 antibodies and uses thereof
HUE056325T2 (hu) 2013-08-26 2022-02-28 Biontech Res And Development Inc SIALYL-LEWIS A elleni humán antitesteket kódoló nukleinsavak
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
WO2015187811A2 (en) 2014-06-04 2015-12-10 MabVax Therapeutics, Inc. Human monoclonal antibodies to ganglioside gd2
KR20240123432A (ko) 2014-12-11 2024-08-13 피에르 파브르 메디카먼트 항-c10orf54 항체들 및 그들의 용도들
JP6621477B2 (ja) 2014-12-18 2019-12-18 ファイザー・インク ピリミジンおよびトリアジン誘導体ならびにaxl阻害薬としてのそれらの使用
LT3265123T (lt) 2015-03-03 2023-01-25 Kymab Limited Antikūnai, naudojimas ir būdai
EP3383908A1 (de) 2015-12-02 2018-10-10 Stsciences, Inc. Spezifische antikörper gegen glykosylierten btla (b- und t-lymphozyt-attenuator)
EP3909983A1 (de) 2015-12-02 2021-11-17 STCube & Co. Inc. Antikörper und moleküle, die immunspezifisch an btn1a1 binden, und therapeutische verwendungen davon
WO2017096165A1 (en) 2015-12-03 2017-06-08 Agios Pharmaceuticals, Inc. Mat2a inhibitors for treating mtap null cancer
EP3534947A1 (de) 2016-11-03 2019-09-11 Kymab Limited Antikörper, kombinationen mit antikörpern, biomarker, verwendungen und verfahren
KR20200024158A (ko) 2017-05-31 2020-03-06 주식회사 에스티큐브앤컴퍼니 Btn1a1에 면역특이적으로 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
EP3630835A1 (de) 2017-05-31 2020-04-08 STCube & Co., Inc. Antikörper und moleküle, die immunspezifisch an btn1a1 binden, und therapeutische verwendungen davon
US11542331B2 (en) 2017-06-06 2023-01-03 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that bind to BTN1A1 or BTN1A1-ligands
US11707522B2 (en) 2017-10-13 2023-07-25 Boehringer Ingelheim International Gmbh Human antibodies to Tn antigen
CA3106418A1 (en) 2018-07-20 2020-01-23 Pierre Fabre Medicament Receptor for vista
WO2021155006A1 (en) 2020-01-31 2021-08-05 Les Laboratoires Servier Sas Inhibitors of cyclin-dependent kinases and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3004728B2 (ja) * 1994-04-29 2000-01-31 ファイザー インク. 神経伝達物質放出増強薬としての新規な非環式および環式アミド類
JPH09183725A (ja) * 1995-09-01 1997-07-15 Pfizer Inc ガン治療用治療剤

Also Published As

Publication number Publication date
WO1997049700A1 (en) 1997-12-31
AP9701039A0 (en) 1997-07-31
US6071935A (en) 2000-06-06
TNSN97110A1 (fr) 2005-03-15
BR9709974A (pt) 1999-08-10
CA2259222A1 (en) 1997-12-31
ID17053A (id) 1997-12-04
MA26432A1 (fr) 2004-12-20
GT199700074A (es) 1998-12-04
AU2710597A (en) 1998-01-14
EP0907649A1 (de) 1999-04-14
JPH11512750A (ja) 1999-11-02

Similar Documents

Publication Publication Date Title
ZA975675B (en) Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one
PL329875A1 (en) Derivatives of carbolin
PL329195A1 (en) Derivatives of 6-phenylpyridol-2-amine
PL339551A1 (en) Derivatives of rezorcin
PL311736A1 (en) Derivatives of 1h-imidazoles
PL327998A1 (en) Novel derivatives of 19-nor-pregnene
PL334218A1 (en) Derivatives of 2-(purin-9-yl)-tetrahydrofurane 3,4-diole
IL134871A0 (en) Polymeric derivatives of campothecins
GB9515412D0 (en) 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
PL326604A1 (en) Derivatives of 5"-dezoxy-cytidin
ZA955753B (en) Heterocyclic derivatives of azolones
PL312692A1 (en) New derivatives of dialkoxy-pyridinol-benzimidazole
PL334769A1 (en) Derivatives of 5-aroylnaphtene
IL108595A0 (en) Novel derivatives of tetramethylcyclopropane
ZA985064B (en) Derivatives of pentaerythrits
PL338777A1 (en) Derivative of piperidinylmethyloxazolydinone
PL333323A1 (en) Derivatives of piperidine
GB9405533D0 (en) Heterocyclic derivatives
PL325816A1 (en) Novel derivatives of naphtylpiperazine
GB9623283D0 (en) Heterocyclic derivatives
GB9722377D0 (en) Heterocyclic derivatives
GB9626857D0 (en) Heterocyclic derivatives
GB9602144D0 (en) Heterocyclic derivatives
GB9602145D0 (en) Heterocyclic derivatives
GB9424295D0 (en) Heterocyclic derivatives