ZA975122B - Radiopharmaceutical compositions capable of localizing at sites of thrombus. - Google Patents

Radiopharmaceutical compositions capable of localizing at sites of thrombus.

Info

Publication number
ZA975122B
ZA975122B ZA9705122A ZA975122A ZA975122B ZA 975122 B ZA975122 B ZA 975122B ZA 9705122 A ZA9705122 A ZA 9705122A ZA 975122 A ZA975122 A ZA 975122A ZA 975122 B ZA975122 B ZA 975122B
Authority
ZA
South Africa
Prior art keywords
localizing
thrombus
sites
compositions capable
radiopharmaceutical compositions
Prior art date
Application number
ZA9705122A
Other languages
English (en)
Inventor
Ananthachari Srinivasan
Larry P Feigen
Daniel Lee Flynn
Jeffrey Alan Zablocki
Philip Needleman
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA975122B publication Critical patent/ZA975122B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9705122A 1996-06-10 1997-06-10 Radiopharmaceutical compositions capable of localizing at sites of thrombus. ZA975122B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1951396P 1996-06-10 1996-06-10

Publications (1)

Publication Number Publication Date
ZA975122B true ZA975122B (en) 1998-06-10

Family

ID=21793614

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9705122A ZA975122B (en) 1996-06-10 1997-06-10 Radiopharmaceutical compositions capable of localizing at sites of thrombus.

Country Status (7)

Country Link
US (1) US6132697A (de)
EP (1) EP0910416A2 (de)
JP (1) JP2001504801A (de)
AU (1) AU3474997A (de)
CA (1) CA2257856A1 (de)
WO (1) WO1997047329A2 (de)
ZA (1) ZA975122B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4910695B2 (ja) * 2004-02-25 2012-04-04 アステラス製薬株式会社 血栓造影剤
US20090317330A2 (en) * 2007-12-21 2009-12-24 Baker Idi Heart And Diabetes Institute Holdings Limited Diagnosis and treatment of diseases involving platelet activation
CN104619717B (zh) * 2012-06-22 2019-04-02 米梅奥亨制药公司 β-转角模拟肽环状化合物的合成

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120526A (en) * 1985-01-14 1992-06-09 Neorx Corporation Method of producing metal radionuclide labeled proteins for diagnosis and therapy
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
DE69200766T2 (de) * 1991-03-06 1995-05-04 G.D. Searle & Co., Chicago, Ill. Phenylamidinderivate als plättchenaggregationsinhibitoren.
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5310536A (en) * 1992-02-06 1994-05-10 Mallinckrodt Medical, Inc. Ligands for improving metal chelate formation kinetics
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
JP2941057B2 (ja) * 1992-05-21 1999-08-25 ダイアテク，インコーポレイテッド 血栓造影用のテクネチウム‐９９ｍ標識ペプチド
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AU6982594A (en) * 1993-06-30 1995-01-24 Nippon Steel Corporation Novel peptide and antiplatelet aggregation containing the same
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators

Also Published As

Publication number Publication date
US6132697A (en) 2000-10-17
AU3474997A (en) 1998-01-07
JP2001504801A (ja) 2001-04-10
WO1997047329A3 (en) 1998-04-09
EP0910416A2 (de) 1999-04-28
WO1997047329A2 (en) 1997-12-18
CA2257856A1 (en) 1997-12-18

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