ZA965798B - Amino-substituted bisphosphonic acids. - Google Patents

Amino-substituted bisphosphonic acids.

Info

Publication number
ZA965798B
ZA965798B ZA9605798A ZA965798A ZA965798B ZA 965798 B ZA965798 B ZA 965798B ZA 9605798 A ZA9605798 A ZA 9605798A ZA 965798 A ZA965798 A ZA 965798A ZA 965798 B ZA965798 B ZA 965798B
Authority
ZA
South Africa
Prior art keywords
amino
bisphosphonic acids
substituted bisphosphonic
substituted
acids
Prior art date
Application number
ZA9605798A
Other languages
English (en)
Inventor
E R Van Beek
C W G M Lowick
Socrates Papapoulos
Rafael Labriola
Adriana Vecchioli
Original Assignee
Gador Sa
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gador Sa, Univ Leiden filed Critical Gador Sa
Publication of ZA965798B publication Critical patent/ZA965798B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA9605798A 1995-07-10 1996-07-09 Amino-substituted bisphosphonic acids. ZA965798B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95110706A EP0753523A1 (en) 1995-07-10 1995-07-10 Amino-substituted bisphosphonic acids

Publications (1)

Publication Number Publication Date
ZA965798B true ZA965798B (en) 1998-01-09

Family

ID=8219423

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9605798A ZA965798B (en) 1995-07-10 1996-07-09 Amino-substituted bisphosphonic acids.

Country Status (8)

Country Link
US (1) US5990098A (xx)
EP (2) EP0753523A1 (xx)
JP (1) JPH11508905A (xx)
AR (1) AR004625A1 (xx)
AU (1) AU6612596A (xx)
DE (1) DE69624707T2 (xx)
WO (1) WO1997002827A1 (xx)
ZA (1) ZA965798B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660468B1 (en) 1998-10-27 2003-12-09 Board Of Trustees Of The University Of Arkansas Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
AR013994A1 (es) * 1998-10-30 2001-01-31 Gador Sa Procedimiento y preparaciones que modulan selectivamente la funcion del osteoblasto para la prevencion y tratamiento de las osteopatias fragilizantes.
AU1525700A (en) 1998-11-19 2000-06-05 Board Of Trustees Of The University Of Arkansas, The Increasing bone strength with selected bisphosphonates
RU2341296C2 (ru) 2002-05-24 2008-12-20 Энджиотек Интернэшнл Аг Композиции и способы покрытия медицинских имплантатов
JP4463274B2 (ja) * 2003-06-27 2010-05-19 明 小谷 ビスホスホネート錯体
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP1758594A1 (en) * 2004-05-19 2007-03-07 Merck and Co., Inc. Combination for inhibiting bone resorption comprising a bisphosponate (alendrona) and a vitamin d (cholecalciferol)
US7068172B2 (en) * 2004-05-21 2006-06-27 Xiao Hui Yang Method and apparatus for deactivating an EAS device
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
JP2008538354A (ja) 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
EP3085377A1 (en) 2008-01-25 2016-10-26 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
BR112012002551A2 (pt) 2009-08-03 2017-06-13 Chimerix Inc composição e métodos de tratamento de infecções virais e tumores induzidos por vírus
PT2534150T (pt) 2010-02-12 2017-05-02 Chimerix Inc Métodos para tratar uma infecção viral
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1002355C2 (de) * 1954-05-03 1957-07-25 Thomae Gmbh Dr K Verfahren zur Herstellung von ª‡-prim.-Amino-diphosphonsaeuren und deren Estern
FR8441M (xx) * 1968-04-01 1971-07-15
DE2405254C2 (de) 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
AR200473A1 (es) 1974-09-17 1974-11-08 Gador Y Cia Sa Com E Ind Lab Procedimiento para preparar acidos 1-hidroxialquiliden-difosfonicos y sus sales
GB1508772A (en) * 1975-04-04 1978-04-26 Shell Int Research Biologically active compositions
DE2534390C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1,3-Di-aminoalkan-1,1-diphosphonsäuren
DE2534391C2 (de) 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
AR218558A1 (es) 1979-09-28 1980-06-13 Gador Lab & Cia Sa Procedimiento para preparar acido 3-amino-1-hidroxi-propilidendifosfonico y sus sales
US4822609A (en) * 1984-12-21 1989-04-18 The Procter & Gamble Company Treatment of osteoporosis
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4868164A (en) 1986-12-19 1989-09-19 Norwich Eaton Pharmaceuticals, Inc. Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5006329A (en) 1988-01-22 1991-04-09 Cadema Medical Products, Inc. Radioactive tagged compounds and method for the treatment of metastatic bone cancer
DE3917153A1 (de) 1989-05-26 1990-11-29 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5103036A (en) 1991-05-13 1992-04-07 E. R. Squibb & Sons, Inc. Process for preparing 3-alkenylidene-1,1-bisphosphonates
EP0541037A3 (en) 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5205253A (en) 1992-08-24 1993-04-27 Ford Motor Company Engine operation interrupt using engine operating parameters
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
JPH09511927A (ja) * 1994-04-18 1997-12-02 ザ、プロクター、エンド、ギャンブル、カンパニー 歯槽骨へのビスホスホネート類のイオン導入デリバリー
AR000555A1 (es) * 1994-12-28 1997-07-10 Gador Sa Uso de composiciones anabolicas para la masa osea en base a cantidades efectivas no toxicas del ácido Ä3-(n,n-dimetilamino)-1-hidroxipropilidenoÜbisfosfonico o la sal monosodica u otra sal farmacéuticamente aceptable del mismo

Also Published As

Publication number Publication date
EP0837682B1 (en) 2002-11-06
DE69624707T2 (de) 2003-03-20
US5990098A (en) 1999-11-23
AR004625A1 (es) 1999-03-10
DE69624707D1 (de) 2002-12-12
EP0837682A1 (en) 1998-04-29
AU6612596A (en) 1997-02-10
JPH11508905A (ja) 1999-08-03
WO1997002827A1 (en) 1997-01-30
EP0753523A1 (en) 1997-01-15

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