ZA964754B - Ketoheterocyclic inhibitors of factor xa - Google Patents

Ketoheterocyclic inhibitors of factor xa

Info

Publication number
ZA964754B
ZA964754B ZA964754A ZA964754A ZA964754B ZA 964754 B ZA964754 B ZA 964754B ZA 964754 A ZA964754 A ZA 964754A ZA 964754 A ZA964754 A ZA 964754A ZA 964754 B ZA964754 B ZA 964754B
Authority
ZA
South Africa
Prior art keywords
ketoheterocyclic
inhibitors
factor
ketoheterocyclic inhibitors
Prior art date
Application number
ZA964754A
Other languages
English (en)
Inventor
Robert M Scarborough
Charles K Marlowe
Bing-Yan Zhu
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of ZA964754B publication Critical patent/ZA964754B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA964754A 1995-06-07 1996-06-06 Ketoheterocyclic inhibitors of factor xa ZA964754B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/486,010 US6069130A (en) 1995-06-07 1995-06-07 Ketoheterocyclic inhibitors of factor Xa

Publications (1)

Publication Number Publication Date
ZA964754B true ZA964754B (en) 1997-03-11

Family

ID=23930257

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA964754A ZA964754B (en) 1995-06-07 1996-06-06 Ketoheterocyclic inhibitors of factor xa

Country Status (9)

Country Link
US (2) US6069130A (fr)
EP (1) EP0832102A1 (fr)
JP (1) JPH11507337A (fr)
AR (2) AR003004A1 (fr)
AU (1) AU702360B2 (fr)
CA (1) CA2224180A1 (fr)
NZ (1) NZ312840A (fr)
WO (1) WO1996040744A1 (fr)
ZA (1) ZA964754B (fr)

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CA2214685C (fr) * 1995-03-10 2008-05-20 Berlex Laboratories, Inc. Derives de benzamidine et utilisation de ces derives en tant qu'anticoagulants
US6069130A (en) * 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
AU5526098A (en) * 1996-12-23 1998-07-17 Biochem Pharma Inc. Bicyclic thrombin inhibitors
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
JP2001521524A (ja) * 1997-04-14 2001-11-06 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
EP0977773A1 (fr) 1997-04-14 2000-02-09 Cor Therapeutics, Inc. INHIBITEURS SELECTIFS DU FACTEUR Xa
CA2289625A1 (fr) 1997-05-15 1998-11-19 Charles Van Jackson Compose antithrombotique
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
CN1311771A (zh) 1998-06-08 2001-09-05 味之素株式会社 苯甲脒衍生物
SK10742001A3 (sk) 1999-01-27 2002-08-06 Ortho-Mcneil Pharmaceutical, Inc. Peptidylové heterocyklické ketóny použiteľné ako inhibítory tryptázy
WO2000051998A1 (fr) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s
US6794412B1 (en) 1999-03-11 2004-09-21 Bristol-Myers Squibb Pharma Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin
EP1161279A1 (fr) * 1999-03-11 2001-12-12 Du Pont Pharmaceuticals Company Traitement de la thrombose au moyen d'une combinaison d'un inhibiteur du facteur xa et d'aspirine, d'un activateur tissulaire du plasminogene (tpa), d'un antagoniste de gpiib/iiia, d'heparine a faible masse moleculaire ou d'heparine
CA2367348A1 (fr) 1999-03-15 2000-09-21 Axys Pharmaceuticals, Inc. Composes et compositions utilises comme inhibiteurs de protease
TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
EP1516877A1 (fr) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Derivés d'amine comme inhibiteurs de protease
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2002006280A2 (fr) * 2000-07-13 2002-01-24 Millennium Pharamaceuticals, Inc. Inhibiteurs du facteur xa
WO2002051983A2 (fr) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Composes et compositions en tant qu'inhibiteurs de cathepsine
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
WO2003024924A1 (fr) 2001-09-14 2003-03-27 Aventis Pharmaceuticals Inc. Nouveaux composes et nouvelles compositions utiles comme inhibiteurs de la cathepsine
MXPA04004450A (es) 2001-11-14 2004-08-11 Aventis Pharma Inc Nuevos compuestos y composiciones como inhibidores de catepsina s.
EP2982668A3 (fr) 2002-12-03 2016-04-13 Pharmacyclics LLC Dérivés de 2-(2-hydroxybiphényl-3-yl)-1h-benzoimidazole-5-carboxamidine en tant qu'inhibiteurs du facteur viia inhibitors pour le traitement de maladies thromboemboliques
CA2651762A1 (fr) 2006-05-23 2007-11-29 Irm Llc Composes et compositions en tant qu'inhibiteurs de proteases activatrices de canal
CA2677487A1 (fr) 2007-02-09 2008-08-14 Irm Llc Composes et compositions servant d'inhibiteurs de protease d'activation de canaux

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US3867364A (en) * 1968-11-21 1975-02-18 Microbial Chem Res Found Process for the synthesis of leupeptins and their analogues
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
GB8312339D0 (en) * 1983-05-05 1983-06-08 Austen B M Peptides
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
CA2021660A1 (fr) * 1989-07-26 1991-01-27 Philippe Bey Inhibiteurs de la peptidose
NZ235155A (en) * 1989-09-11 1993-04-28 Merrell Dow Pharma Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical
JPH0813834B2 (ja) * 1990-08-01 1996-02-14 日東紡績株式会社 トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
CA2075154A1 (fr) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Aldehydes peptidiques utilises comme agents antithrombotiques
EP0627925B1 (fr) * 1992-01-30 2004-09-29 Dendreon Corporation Inhibiteurs de trypsine
DE69321344D1 (de) * 1992-02-14 1998-11-05 Corvas Int Inc Inhibitoren der thrombose
US5371072A (en) * 1992-10-16 1994-12-06 Corvas International, Inc. Asp-Pro-Arg α-keto-amide enzyme inhibitors
DE69324041D1 (de) * 1992-12-15 1999-04-22 Corvas Int Inc NEUE INHIBITOREN VON FAKTOR Xa
WO1994017817A1 (fr) 1993-02-12 1994-08-18 Corvas International, Inc. Inhibiteurs de la thrombose
CA2159834A1 (fr) * 1993-04-30 1994-11-10 Daniel F. Veber Inhibiteurs de la thrombine
JP3388803B2 (ja) * 1993-05-20 2003-03-24 第一製薬株式会社 光学活性７−アミジノナフタレン誘導体の製造法
EP0648780A1 (fr) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Inhibiteurs hétérocycliques de thrombine
IL111175A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
KR100380124B1 (ko) * 1994-04-26 2003-08-02 셀렉타이드 코포레이션 인자Xa억제제
US5637599A (en) 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US6025472A (en) * 1994-12-21 2000-02-15 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
WO1996019491A1 (fr) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Peptides de cetoarginine heterocycliques utilises comme inhibiteurs de thrombine
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) * 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5612369A (en) 1995-06-07 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Thrombin inhibitors
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders

Also Published As

Publication number Publication date
AU702360B2 (en) 1999-02-18
WO1996040744A1 (fr) 1996-12-19
US6197748B1 (en) 2001-03-06
US6069130A (en) 2000-05-30
AR003004A1 (es) 1998-05-27
AR025799A1 (es) 2002-12-18
MX9709908A (es) 1998-07-31
AU6476196A (en) 1996-12-30
NZ312840A (en) 1999-11-29
EP0832102A1 (fr) 1998-04-01
JPH11507337A (ja) 1999-06-29
CA2224180A1 (fr) 1996-12-19

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