ZA963593B - IL-6 activity inhibitor - Google Patents
IL-6 activity inhibitorInfo
- Publication number
- ZA963593B ZA963593B ZA963593A ZA963593A ZA963593B ZA 963593 B ZA963593 B ZA 963593B ZA 963593 A ZA963593 A ZA 963593A ZA 963593 A ZA963593 A ZA 963593A ZA 963593 B ZA963593 B ZA 963593B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- nucleotide sequence
- date nov
- absent
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1995/001778 WO1996035782A1 (fr) | 1995-05-11 | 1995-05-11 | Inhibiteur de l'activite de il-6 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA963593B true ZA963593B (en) | 1996-11-25 |
Family
ID=8166014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA963593A ZA963593B (en) | 1995-05-11 | 1996-05-07 | IL-6 activity inhibitor |
Country Status (17)
Country | Link |
---|---|
US (1) | US6004813A (fr) |
EP (1) | EP0824588B1 (fr) |
JP (1) | JP4173539B2 (fr) |
KR (1) | KR100449677B1 (fr) |
AT (1) | ATE271128T1 (fr) |
AU (1) | AU715125B2 (fr) |
CA (1) | CA2220433C (fr) |
DE (1) | DE69533264T2 (fr) |
DK (1) | DK0824588T3 (fr) |
ES (1) | ES2220929T3 (fr) |
HK (1) | HK1016213A1 (fr) |
IL (1) | IL118158A (fr) |
MX (1) | MX9708663A (fr) |
RU (1) | RU2205874C2 (fr) |
UA (1) | UA63888C2 (fr) |
WO (1) | WO1996035782A1 (fr) |
ZA (1) | ZA963593B (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6727230B1 (en) | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
CA2237114A1 (fr) * | 1995-11-07 | 1997-05-15 | Kaneka Corporation | Autoantigenes |
EP0855184A1 (fr) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | LPS関連障害の処置における非メチル化CpGジヌクレオチドを含む核酸の使用 |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
ATE356630T1 (de) | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
EP0972780A1 (fr) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Peptides antagonistes de l'Il-6 |
RU2001106631A (ru) * | 1998-09-11 | 2004-03-20 | Адзиномото Ко., Инк. (Jp) | Производные бензола и их фармацевтическое применение |
AU7078200A (en) | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use |
US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
AU2003216585A1 (en) * | 2002-04-10 | 2003-10-20 | Orchid Chemicals And Pharmaceuticals Limited | Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases |
US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
CA2555185C (fr) * | 2004-02-06 | 2020-03-24 | Morphosys Ag | Anticorps humains anti-cd38 et utilisations de ceux-ci |
KR20080025662A (ko) * | 2005-03-18 | 2008-03-21 | 오키드 케미칼즈 앤드 파마수티컬즈 리미티드 | 신규 티로신 유도체 |
US20080267888A1 (en) * | 2005-05-26 | 2008-10-30 | Pandey Surendrakumar Satyanara | Heterocyclic Derivatives |
WO2007000655A2 (fr) * | 2005-06-28 | 2007-01-04 | Orchid Research Laboratories Limited | Nouveaux dérivés de pyrazolopyrimidinone |
AU2006301446B2 (en) | 2005-10-12 | 2012-06-07 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 |
US7863446B2 (en) * | 2006-01-19 | 2011-01-04 | Orchid Research Laboratories Limited | Heterocycles |
PL1973884T3 (pl) * | 2006-01-19 | 2017-05-31 | Orchid Pharma Limited | Nowe związki heterocykliczne |
US20080221103A1 (en) * | 2007-03-09 | 2008-09-11 | Orchid Research Laboratories Ltd. | New heterocyclic compounds |
JP5646320B2 (ja) * | 2007-05-11 | 2014-12-24 | アダイニクス, インコーポレイテッド | 遺伝子発現と疼痛 |
AU2009208712B2 (en) | 2008-02-01 | 2013-03-14 | Orchid Chemicals & Pharmaceuticals Limited | Novel heterocycles |
BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
WO2013012758A1 (fr) | 2011-07-19 | 2013-01-24 | Ontorii, Inc. | Procédés pour la synthèse d'acides nucléiques fonctionnalisés |
CA2872901A1 (fr) | 2012-05-10 | 2013-11-14 | Adynxx, Inc. | Formulations pour l'administration de principes actifs |
RU2677639C2 (ru) | 2012-07-13 | 2019-01-18 | Шин Ниппон Биомедикал Лэбораториз, Лтд. | Хиральный адъювант нуклеиновой кислоты |
CN104684893B (zh) | 2012-07-13 | 2016-10-26 | 日本波涛生命科学公司 | 不对称辅助基团 |
KR102450907B1 (ko) | 2012-07-13 | 2022-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
US10149905B2 (en) | 2014-01-15 | 2018-12-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
KR20230152178A (ko) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
CN106661578B (zh) | 2014-08-15 | 2020-08-04 | 埃迪恩克斯股份有限公司 | 用于疼痛治疗的寡核苷酸诱饵 |
-
1995
- 1995-05-11 MX MX9708663A patent/MX9708663A/es unknown
- 1995-05-11 AU AU25267/95A patent/AU715125B2/en not_active Expired
- 1995-05-11 AT AT95919438T patent/ATE271128T1/de active
- 1995-05-11 ES ES95919438T patent/ES2220929T3/es not_active Expired - Lifetime
- 1995-05-11 JP JP53368396A patent/JP4173539B2/ja not_active Expired - Lifetime
- 1995-05-11 DE DE69533264T patent/DE69533264T2/de not_active Expired - Lifetime
- 1995-05-11 RU RU97120584/13A patent/RU2205874C2/ru active
- 1995-05-11 CA CA2220433A patent/CA2220433C/fr not_active Expired - Lifetime
- 1995-05-11 KR KR1019970708022A patent/KR100449677B1/ko not_active IP Right Cessation
- 1995-05-11 US US08/945,726 patent/US6004813A/en not_active Expired - Lifetime
- 1995-05-11 WO PCT/EP1995/001778 patent/WO1996035782A1/fr active IP Right Grant
- 1995-05-11 EP EP95919438A patent/EP0824588B1/fr not_active Expired - Lifetime
- 1995-05-11 DK DK95919438T patent/DK0824588T3/da active
- 1995-11-05 UA UA97126018A patent/UA63888C2/uk unknown
-
1996
- 1996-05-06 IL IL11815896A patent/IL118158A/en not_active IP Right Cessation
- 1996-05-07 ZA ZA963593A patent/ZA963593B/xx unknown
-
1998
- 1998-11-09 HK HK98111831A patent/HK1016213A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
UA63888C2 (en) | 2004-02-16 |
ATE271128T1 (de) | 2004-07-15 |
EP0824588A1 (fr) | 1998-02-25 |
KR19990014681A (ko) | 1999-02-25 |
WO1996035782A1 (fr) | 1996-11-14 |
EP0824588B1 (fr) | 2004-07-14 |
AU2526795A (en) | 1996-11-29 |
HK1016213A1 (en) | 1999-10-29 |
RU2205874C2 (ru) | 2003-06-10 |
CA2220433A1 (fr) | 1996-11-14 |
ES2220929T3 (es) | 2004-12-16 |
DK0824588T3 (da) | 2004-08-16 |
IL118158A (en) | 2004-07-25 |
IL118158A0 (en) | 1996-09-12 |
AU715125B2 (en) | 2000-01-20 |
KR100449677B1 (ko) | 2004-11-20 |
JP4173539B2 (ja) | 2008-10-29 |
US6004813A (en) | 1999-12-21 |
JPH11504816A (ja) | 1999-05-11 |
MX9708663A (es) | 1998-02-28 |
DE69533264D1 (de) | 2004-08-19 |
CA2220433C (fr) | 2010-02-16 |
DE69533264T2 (de) | 2004-11-25 |
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