ZA961948B - 6-aryl pyrazoloÚ3,4-d¾pyrimidin-4-ones and compositions and methods of use thereof - Google Patents

6-aryl pyrazoloÚ3,4-d¾pyrimidin-4-ones and compositions and methods of use thereof

Info

Publication number
ZA961948B
ZA961948B ZA961948A ZA961948A ZA961948B ZA 961948 B ZA961948 B ZA 961948B ZA 961948 A ZA961948 A ZA 961948A ZA 961948 A ZA961948 A ZA 961948A ZA 961948 B ZA961948 B ZA 961948B
Authority
ZA
South Africa
Prior art keywords
aryl
ones
compositions
methods
Prior art date
Application number
ZA961948A
Other languages
English (en)
Inventor
Edward R Bacon
Baldev Singh
Original Assignee
Sanofi Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Winthrop Inc filed Critical Sanofi Winthrop Inc
Publication of ZA961948B publication Critical patent/ZA961948B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA961948A 1995-03-10 1996-03-11 6-aryl pyrazoloÚ3,4-d¾pyrimidin-4-ones and compositions and methods of use thereof ZA961948B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40226195A 1995-03-10 1995-03-10

Publications (1)

Publication Number Publication Date
ZA961948B true ZA961948B (en) 1996-09-17

Family

ID=23591191

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA961948A ZA961948B (en) 1995-03-10 1996-03-11 6-aryl pyrazoloÚ3,4-d¾pyrimidin-4-ones and compositions and methods of use thereof

Country Status (13)

Country Link
US (2) US5736548A (cs)
EP (1) EP0813534A4 (cs)
JP (1) JPH11501926A (cs)
KR (1) KR19980702892A (cs)
AU (1) AU708809B2 (cs)
CA (1) CA2211729A1 (cs)
CZ (1) CZ280697A3 (cs)
HU (1) HUP9801394A3 (cs)
NO (1) NO974150L (cs)
NZ (1) NZ303886A (cs)
PL (1) PL322452A1 (cs)
WO (1) WO1996028448A1 (cs)
ZA (1) ZA961948B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
DE19709877A1 (de) * 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
KR100441229B1 (ko) 1997-04-25 2004-07-22 화이자 인코포레이티드 타입 5 시클릭 구아노신 3',5'-모노포스페이트 포스포디에스테라제(ｃＧＭＰ ＰＤＥ5)를 억제하는 성기능 장애 치료용 피라졸로피리미디논
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
ES2242124T3 (es) * 1998-04-20 2005-11-01 Pfizer Inc. Derivados del acido piridin-3-carboxilico y su uso como productos intermedios.
GB9823103D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823101D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823102D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
US6225315B1 (en) * 1998-11-30 2001-05-01 Pfizer Inc Method of treating nitrate-induced tolerance
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
TWI265925B (en) * 1999-10-11 2006-11-11 Pfizer Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
EA200200240A1 (ru) 1999-10-11 2002-10-31 Пфайзер Инк. 5-(2-ЗАМЕЩЕННЫЕ-5-ГЕТЕРОЦИКЛИЛСУЛЬФОНИЛПИРИД-3-ИЛ)-ДИГИДРОПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
WO2004096810A1 (en) 2003-04-29 2004-11-11 Pfizer Limited 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension
JP2007504243A (ja) * 2003-09-03 2007-03-01 ニューロジェン・コーポレーション ５−アリール−ピラゾロ［４，３−ｄ］ピリミジン類、ピリジン類、ピラジン類及び関連化合物
WO2013083206A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphtalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract
CN104540830A (zh) * 2012-06-07 2015-04-22 霍夫曼-拉罗奇有限公司 端锚聚合酶的吡唑并嘧啶酮和吡唑并吡啶酮抑制剂
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
EP3562828A1 (en) 2016-12-28 2019-11-06 Dart NeuroScience LLC Substituted pyrazolopyrimidinone compounds as pde2 inhibitors
CA3120971A1 (en) 2017-11-27 2019-05-31 Dart Neuroscience, Llc Substituted furanopyrimidine compounds as pde1 inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211732A (en) * 1965-10-12 Pyrazolob:x-d]pyrlil/hdines
US3165520A (en) * 1965-01-12 Certificate of correction
GB937722A (en) * 1960-05-11 1963-09-25 Ciba Ltd New pyrazolopyrimidines and process for the preparation thereof
CH398626A (de) * 1960-05-11 1966-03-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
GB1284084A (en) * 1969-04-17 1972-08-02 Delmar Chem PROCESS FOR MAKING 1H-PYRAZOLO[3,4-d]PYRIMIDINES
US3732225A (en) * 1970-07-23 1973-05-08 Squibb & Sons Inc Pyrazolo(3,4-d)pyrimidine derivatives
US4666908A (en) * 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
US5075310A (en) * 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9121028D0 (en) * 1991-10-03 1991-11-13 Pfizer Ltd Therapeutic agents
US5294612A (en) * 1992-03-30 1994-03-15 Sterling Winthrop Inc. 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
GB9315017D0 (en) * 1993-07-20 1993-09-01 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
EP0813534A4 (en) 1998-06-10
WO1996028448A1 (en) 1996-09-19
PL322452A1 (en) 1998-02-02
HUP9801394A3 (en) 2000-07-28
AU5093396A (en) 1996-10-02
NO974150L (no) 1997-11-07
NZ303886A (en) 1998-11-25
US5736548A (en) 1998-04-07
US5958929A (en) 1999-09-28
NO974150D0 (no) 1997-09-09
EP0813534A1 (en) 1997-12-29
HUP9801394A2 (hu) 1998-10-28
AU708809B2 (en) 1999-08-12
JPH11501926A (ja) 1999-02-16
MX9706878A (es) 1998-06-28
CA2211729A1 (en) 1996-09-19
CZ280697A3 (cs) 1998-04-15
KR19980702892A (ko) 1998-08-05

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