ZA961820B - Proteinase K variants with decreased adsorption and increased hydrolysis - Google Patents

Proteinase K variants with decreased adsorption and increased hydrolysis

Info

Publication number
ZA961820B
ZA961820B ZA961820A ZA961820A ZA961820B ZA 961820 B ZA961820 B ZA 961820B ZA 961820 A ZA961820 A ZA 961820A ZA 961820 A ZA961820 A ZA 961820A ZA 961820 B ZA961820 B ZA 961820B
Authority
ZA
South Africa
Prior art keywords
proteinase
variants
increased hydrolysis
decreased adsorption
adsorption
Prior art date
Application number
ZA961820A
Other languages
English (en)
Inventor
Brode Philip Frederick Iii
Bobby Lee Barnett
Donn Nelton Rubingh
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of ZA961820B publication Critical patent/ZA961820B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0073—Tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0069—Laundry bars
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0073—Tablets
    • C11D17/0078—Multilayered tablets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0052—Gas evolving or heat producing compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA961820A 1995-03-09 1996-03-06 Proteinase K variants with decreased adsorption and increased hydrolysis ZA961820B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40157495A 1995-03-09 1995-03-09

Publications (1)

Publication Number Publication Date
ZA961820B true ZA961820B (en) 1996-09-10

Family

ID=23588288

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA961820A ZA961820B (en) 1995-03-09 1996-03-06 Proteinase K variants with decreased adsorption and increased hydrolysis

Country Status (14)

Country Link
US (1) US6451574B1 (xx)
EP (1) EP0813601A2 (xx)
JP (1) JPH11501814A (xx)
CN (1) CN1183809A (xx)
AU (1) AU5092796A (xx)
BR (1) BR9607677A (xx)
CA (1) CA2214395C (xx)
CZ (1) CZ279997A3 (xx)
HU (1) HUP9801638A3 (xx)
IL (1) IL117350A0 (xx)
MA (1) MA23820A1 (xx)
MX (1) MX9706841A (xx)
WO (1) WO1996028556A2 (xx)
ZA (1) ZA961820B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10204500A (ja) * 1997-01-20 1998-08-04 Soft Kyukyu Corp:Kk 発泡錠剤洗浄剤
MA24811A1 (fr) * 1997-10-23 1999-12-31 Procter & Gamble Compositions de lavage contenant des variantes de proteases multisubstituees
ES2367505T3 (es) 1997-10-23 2011-11-04 Danisco Us Inc. Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes.
WO1999032594A1 (en) * 1997-12-22 1999-07-01 The Procter & Gamble Company Cleaning compositions containing a neopullulanase
ATE471377T1 (de) * 2000-04-28 2010-07-15 Novozymes As Variante eines lipolytischen enzyms
US6803222B2 (en) * 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
DE10105912A1 (de) * 2001-02-09 2002-08-14 Roche Diagnostics Gmbh Rekombinante Proteinase K
DE10105911A1 (de) 2001-02-09 2002-08-14 Roche Diagnostics Gmbh Expression der rekombinanten Proteinase K aus Tritirachium album in Hefe
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
US7888093B2 (en) 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
DE10260903A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Neue Perhydrolasen
US7294499B2 (en) * 2003-01-30 2007-11-13 Novozymes A/S Subtilases
US7153666B2 (en) 2003-07-17 2006-12-26 General Atomics Methods and compositions for determination of glycated proteins
US7943385B2 (en) 2006-07-25 2011-05-17 General Atomics Methods for assaying percentage of glycated hemoglobin
JP2009544315A (ja) 2006-07-25 2009-12-17 ジェネラル アトミクス 糖化ヘモグロビンのパーセントを定量するための方法
EP2283149A1 (en) * 2008-05-13 2011-02-16 General Atomics Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
CN105193640B (zh) * 2014-06-24 2018-10-12 金普诺安蛋白质工程技术（北京）有限公司 蛋白酶k在皮肤保健和化妆品领域中的应用
WO2017089456A1 (en) * 2015-11-24 2017-06-01 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
CN109207460B (zh) * 2018-10-23 2021-06-15 大连博格林生物科技有限公司 重组布氏白僵菌蛋白酶k突变体pk-m2及制备方法
CN109280656B (zh) * 2018-10-23 2021-06-15 大连博格林生物科技有限公司 重组布氏白僵菌蛋白酶k突变体pk-m1及制备方法
US10633644B1 (en) * 2018-12-20 2020-04-28 New England Biolabs, Inc. Proteinases with improved properties
CN112592931A (zh) * 2020-12-31 2021-04-02 安徽丰原发酵技术工程研究有限公司 一种生产重组蛋白酶k的方法
CN113913412B (zh) * 2021-10-13 2023-10-03 湖北大学 蛋白酶k突变体及其制备方法
CN114196656B (zh) * 2021-12-29 2023-10-24 南京巨匠生物科技有限公司 一种蛋白酶k突变体及其表达载体的构建和应用
CN115775591B (zh) * 2023-01-10 2023-06-09 华测检测认证集团股份有限公司 一种引物设计方法、装置、设备及可读存储介质

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310675A (en) * 1983-06-24 1994-05-10 Genencor, Inc. Procaryotic carbonyl hydrolases
NZ208612A (en) * 1983-06-24 1991-09-25 Genentech Inc Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5763257A (en) * 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
US5346823A (en) * 1984-05-29 1994-09-13 Genencor, Inc. Subtilisin modifications to enhance oxidative stability
US5182204A (en) * 1984-05-29 1993-01-26 Genencor International, Inc. Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors
US5371008A (en) * 1984-05-29 1994-12-06 Genencor International, Inc. Substrate assisted catalysis
US5155033A (en) * 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
US5244791A (en) * 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5972682A (en) * 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5185258A (en) * 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US5371190A (en) * 1984-05-29 1994-12-06 Genencor International, Inc. Substrate assisted catalysis
JP2599946B2 (ja) 1986-01-15 1997-04-16 アムジェン，インコーポレイテツド ズブチリシン類似体
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
US5013657A (en) 1988-04-12 1991-05-07 Bryan Philip N Subtilisin mutations
US4980288A (en) 1986-02-12 1990-12-25 Genex Corporation Subtilisin with increased thermal stability
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
EP0260299A4 (en) 1986-02-12 1988-11-24 Genex Corp MUTAGENESIS AND SCREENING PROCESS AND PRODUCT OBTAINED.
US5240632A (en) * 1986-03-26 1993-08-31 Amway Corporation Machine dishwasher water spot control composition
ATE116365T1 (de) * 1986-04-30 1995-01-15 Genencor Int Mutante einer nicht menschlichen carbonyl- hydrolase, für diese kodierende dns-sequenzen und vektoren und durch diese vektoren transformierte wirte.
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
PT86864B (pt) * 1987-02-27 1992-05-29 Gist Brocades Nv Processo para clonagem molecular e expressao de genes que codificam para enzimas proteoliticas
US5260207A (en) * 1987-04-06 1993-11-09 Enzon Labs Inc. Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
ATE184316T1 (de) * 1987-04-06 1999-09-15 Novo Nordisk As Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
PT89702B (pt) * 1988-02-11 1994-04-29 Gist Brocades Nv Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
US6287841B1 (en) * 1988-02-11 2001-09-11 Genencor International, Inc. High alkaline serine protease
US5324653A (en) * 1988-02-11 1994-06-28 Gist-Brocades N.V. Recombinant genetic means for the production of serine protease muteins
US5116741A (en) 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
US5246849A (en) 1988-04-12 1993-09-21 Enzon, Inc. Thermally stable serine proteases
US5118623A (en) * 1988-05-27 1992-06-02 Solvay Enzymes, Inc. Bleach stable enzymes
AU618675B2 (en) * 1989-05-17 1992-01-02 Amgen, Inc. Multiply mutated subtilisins
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
EP0405902A1 (en) 1989-06-26 1991-01-02 Unilever Plc Enymatic detergent compositions
DK316989D0 (da) 1989-06-26 1989-06-26 Novo Nordisk As Enzymer
BR9006827A (pt) * 1989-06-26 1991-08-06 Unilever Nv Composicoes detergentes enzimaticas
US5352603A (en) * 1989-08-31 1994-10-04 Kali-Chemie Ag Highly alkaline proteases
US6271012B1 (en) * 1989-10-11 2001-08-07 Genencor International, Inc. Protease muteins and their use in detergents
DE4009534A1 (de) * 1990-03-24 1991-09-26 Henkel Kgaa Fluessiges handreinigungsmittel
DK97190D0 (da) * 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
US5629173A (en) * 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
DE69131834T2 (de) * 1990-08-09 2000-05-31 Genentech, Inc. Serinproteasevarianten mit peptidligase aktivität
DK271490D0 (da) * 1990-11-14 1990-11-14 Novo Nordisk As Detergentkomposition
EP0563169B2 (en) 1990-12-21 2006-04-12 Novozymes A/S ENZYME MUTANTS HAVING A LOW DEGREE OF VARIATION OF THE MOLECULAR CHARGE OVER A pH RANGE
US5482849A (en) * 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
US5340735A (en) * 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
DE4224125A1 (de) * 1991-07-27 1993-01-28 Solvay Enzymes Gmbh & Co Kg Verfahren zur verbesserung der stabilitaet von enzymen und stabilisierte enzyme
US5275945A (en) * 1991-10-08 1994-01-04 Vista Chemical Company Alkaline proteases stable in heavy-duty detergent liquids
ES2296285T3 (es) * 1992-07-17 2008-04-16 Genencor International, Inc. Serin proteasas altamente alcalinas.
US5470733A (en) * 1993-06-01 1995-11-28 University Of Maryland Calcium free subtilisin mutants
US5567601A (en) * 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
AU7870394A (en) 1993-09-15 1995-04-03 Procter & Gamble Company, The Subtilisin bpn' variants with decreased adsorption and increased hydrolysis
US6436690B1 (en) * 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
BR9407833A (pt) * 1993-10-14 1997-05-13 Procter & Gamble Composições alvejantes compreendendo enzimas protease
BR9407834A (pt) * 1993-10-14 1997-05-13 Procter & Gamble Composições de limpeza contendo protease
ES2364774T3 (es) * 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
US6599730B1 (en) * 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
US5780285A (en) * 1995-03-03 1998-07-14 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing dibasic residues

Also Published As

Publication number Publication date
MX9706841A (es) 1997-11-29
JPH11501814A (ja) 1999-02-16
AU5092796A (en) 1996-10-02
BR9607677A (pt) 1998-07-07
MA23820A1 (fr) 1996-10-01
CA2214395A1 (en) 1996-09-19
CA2214395C (en) 2001-10-30
HUP9801638A2 (hu) 1998-10-28
EP0813601A2 (en) 1997-12-29
WO1996028556A2 (en) 1996-09-19
CN1183809A (zh) 1998-06-03
HUP9801638A3 (en) 2001-01-29
CZ279997A3 (cs) 1998-01-14
US6451574B1 (en) 2002-09-17
WO1996028556A3 (en) 1997-07-17
IL117350A0 (en) 1996-07-23

Similar Documents

Publication Publication Date Title
ZA961820B (en) Proteinase K variants with decreased adsorption and increased hydrolysis
AU2294495A (en) Subtilisin 309 variants having decreased adsorption and increased hydrolysis
HUP9800765A3 (en) Subtilisin carlsberg variants having decreased adsorption and increased hydrolysis
HU9603031D0 (en) Subtilisin bpn'variants having decreased adsorption and increased hydrolysis
EP0837933A4 (en) OPTIMIZED MINIZYMES AND MINIRIBOZYMES AND THE USE THEREOF
ZA952220B (en) Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
GB9521120D0 (en) Improvements in stopcocks
ZA9610703B (en) Coextruded blocks and applications therefor
IL123449A0 (en) Toothbrush and its manufacture
ZA962768B (en) Benzonitriles and benzofluorides
ZA961821B (en) Subtilisin dy variants with decreased adsorption and increased hydrolysis
ZA96428B (en) P-heteroatom-substituted phenols and uses thereof
ZA961822B (en) Thermitase variants with decreased adsorption and increased hydrolysis
EP0836617A4 (en) PAREVINES AND TACHYTEGRINES
ZA964862B (en) Optimized minizymes and miniribozymes and uses thereof
GB9504030D0 (en) Break and stop lighting sensor
AU3479495A (en) Alpha-1-antitrypsin and antithrombine-iii variants
EP0744125A3 (en) Iodine complex and its application
IL117164A0 (en) Cold-active protease and cold-active bacteria
PL324340A1 (en) Novel quinoxalinophosphonic and quinoxalinoalkanophosphonic acids
ZA959512B (en) Aryloxycycloalkenyl and aryloxyiminocycloalkenylhy-droxyureas
ZA947078B (en) Serine protease with decreased adsorption and increased hydrolysis
CA74282S (en) Ornamental butterfly
GB9304269D0 (en) Aerogel-containing galzing unit and manufacture thereof
HU9500316V0 (en) Shooting-board with balls