ZA956679B - Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis. - Google Patents

Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis.

Info

Publication number
ZA956679B
ZA956679B ZA9506679A ZA956679A ZA956679B ZA 956679 B ZA956679 B ZA 956679B ZA 9506679 A ZA9506679 A ZA 9506679A ZA 956679 A ZA956679 A ZA 956679A ZA 956679 B ZA956679 B ZA 956679B
Authority
ZA
South Africa
Prior art keywords
congeners
hematopoiesis
improvement
acyl derivatives
oxypurine nucleosides
Prior art date
Application number
ZA9506679A
Other languages
English (en)
Inventor
Reid Warren Von Borstel
Michael Kevin Bamat
Bradley Mark Hiltbrand
James Charles Butler
Shyam Shirali
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of ZA956679B publication Critical patent/ZA956679B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA9506679A 1994-08-12 1995-08-10 Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis. ZA956679B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28921494A 1994-08-12 1994-08-12

Publications (1)

Publication Number Publication Date
ZA956679B true ZA956679B (en) 1997-02-10

Family

ID=23110539

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9506679A ZA956679B (en) 1994-08-12 1995-08-10 Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis.

Country Status (12)

Country Link
US (1) US20040235782A1 (sv)
EP (2) EP1157698A3 (sv)
JP (2) JPH10507441A (sv)
KR (1) KR100290129B1 (sv)
AU (1) AU712835B2 (sv)
CA (1) CA2197205A1 (sv)
FI (1) FI970588A (sv)
IL (1) IL114887A0 (sv)
NO (3) NO970631L (sv)
RU (1) RU2203669C2 (sv)
WO (1) WO1996004923A1 (sv)
ZA (1) ZA956679B (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19818044A1 (de) * 1998-04-22 1999-10-28 Klinge Co Chem Pharm Fab Verwendung von Vitamin-PP-Verbindungen
DK1278748T3 (da) 2000-04-25 2011-04-18 Icos Corp Inhibitorer af human phosphatidyl-inositol 3-kinase delta
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
WO2003047602A1 (en) * 2001-12-07 2003-06-12 Intercell Ag Immunostimulatory oligodeoxynucleotides
UA82205C2 (en) 2002-09-30 2008-03-25 Байер Фармасьютикалз Корпорейшн Fused azole-pyrimidine derivatives
US6997018B2 (en) 2003-06-02 2006-02-14 Ferro Corporation Method of micro and nano texturing glass
AU2005245875C1 (en) 2004-05-13 2017-08-31 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
EP2187894B1 (en) 2007-08-16 2020-03-18 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. D. radiodurans extract containing nucleosides and manganese
CN104042618B (zh) 2008-11-13 2018-02-16 吉利德卡利斯托加公司 恶性血液病的治疗
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
WO2010111432A1 (en) 2009-03-24 2010-09-30 Calistoga Pharmaceuticals Inc. Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
EA201101507A1 (ru) 2009-04-20 2012-05-30 Гилеад Калистога Ллс. Способы лечения солидных опухолей
JP2013500257A (ja) 2009-07-21 2013-01-07 ギリアード カリストガ エルエルシー Ｐｉ３ｋインヒビターでの肝障害の処置
AU2011248517B2 (en) * 2010-04-29 2016-02-25 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions containing purine and pyrimidine nucleosides, peptides, and manganese and their uses
KR20140133590A (ko) 2012-03-05 2014-11-19 길리아드 칼리스토가 엘엘씨 (s)-2-(1-(9h-퓨린-6-일아미노)프로필)-5-플루오로-3-페닐퀴나졸린-4(3h)-온의 다형체 형태
CA2934531C (en) 2013-12-20 2020-02-25 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
US9708327B2 (en) 2013-12-20 2017-07-18 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
MX2016016530A (es) 2014-06-13 2017-03-27 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-quinasa.
CA3190751A1 (en) * 2020-08-24 2022-03-03 Noam Sheffer Pesticidal compounds and compositions, methods of use and processes of preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE179615T1 (de) * 1991-02-08 1999-05-15 Pro Neuron Inc Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese
US5320846A (en) * 1991-04-17 1994-06-14 New England Deaconess Hospital Corp. Method and composition for testing patients with metabolic depleting diseases

Also Published As

Publication number Publication date
KR970704457A (ko) 1997-09-06
EP1157698A2 (en) 2001-11-28
EP0771204A1 (en) 1997-05-07
JPH10507441A (ja) 1998-07-21
FI970588A (sv) 1997-04-11
NO20041007L (no) 2004-03-10
NO20016068D0 (no) 2001-12-12
FI970588A0 (sv) 1997-02-12
KR100290129B1 (ko) 2001-05-15
NO970631D0 (no) 1997-02-11
JP2009221221A (ja) 2009-10-01
NO20016068L (no) 1997-04-11
NO317199B1 (no) 2004-09-13
EP0771204A4 (en) 1999-10-20
WO1996004923A1 (en) 1996-02-22
EP1157698A3 (en) 2002-05-02
AU3278495A (en) 1996-03-07
RU2203669C2 (ru) 2003-05-10
CA2197205A1 (en) 1996-02-22
NO970631L (no) 1997-04-11
IL114887A0 (en) 1995-12-08
AU712835B2 (en) 1999-11-18
US20040235782A1 (en) 2004-11-25

Similar Documents

Publication Publication Date Title
ZA956679B (en) Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis.
PH31455A (en) Acyl derivatives of azolone.
GB2319250B (en) Derivatives of 6,8-Difluoro-7-Hydroxycoumarin
NZ329176A (en) 2,5-dioxo-imidazolidine derivatives and medicaments
GB9501465D0 (en) Nucleoside phosphorothioate derivatives,synthesis and use thereof
HUP9601566A3 (en) Therapeutic tetrahydro-isoquinolin derivatives, their intermediates and pharmaceutical compositions containing the active component
HUP9901086A3 (en) Arylsulfonylaminobenzene derivatives, pharmaceutical compositions containing them and their use for producing pharmaceutical compositions
GB9321855D0 (en) 1,4-piperazine derivatives
HUP0004225A3 (en) Pyridine derivatives, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing the same
NZ297211A (en) Benzylamine derivatives
HU9300250D0 (en) One-bladed reamer
HUP0002869A3 (en) Benzothiophenecarboxamide derivatives, pharmaceutical compositions thereof and intermediates
HK1012193A1 (en) Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
NZ236582A (en) Azaoxindole derivatives, pharmaceutical compositions and intermediates
HK1007880A1 (en) 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity
GB2271059B (en) Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives.
HUP9904694A3 (en) Spiropyrrolidine derivatives, their use and pharmaceutical compositions containing them
ZA964129B (en) N-acyl-2-aryl cyclopropylmethylamine derivatives as melatonerigics
GB9209008D0 (en) Reamer
NZ305898A (en) Taxoid derivatives and medicaments
HUP0000203A3 (en) Naphthyl derivatives, pharmaceutical compositions containing them and intermediates
NZ291597A (en) Carboxycyclopropan-1-yl derivatives, preparation, pharmaceutical compositions and intermediates thereof
HUP9602774A2 (en) Benzoxazepine derivatives, pharmaceutical compositions containing them and intermediates
HUP0600457A2 (en) 14alpha, 17alpha-c2-bridged 19-nor-progesterone derivatives, pharmaceutical compositions thereof and intermediates
HU9603105D0 (en) Adenosine derivatives