ZA955288B - Oligonucleotides to inhibit the expression of isoprenyl protein transferases - Google Patents

Oligonucleotides to inhibit the expression of isoprenyl protein transferases

Info

Publication number
ZA955288B
ZA955288B ZA955288A ZA955288A ZA955288B ZA 955288 B ZA955288 B ZA 955288B ZA 955288 A ZA955288 A ZA 955288A ZA 955288 A ZA955288 A ZA 955288A ZA 955288 B ZA955288 B ZA 955288B
Authority
ZA
South Africa
Prior art keywords
oligonucleotides
inhibit
expression
protein transferases
isoprenyl protein
Prior art date
Application number
ZA955288A
Other languages
English (en)
Inventor
Soudhir Colote
Eduardo Pirotzky
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Publication of ZA955288B publication Critical patent/ZA955288B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
ZA955288A 1994-06-29 1995-06-26 Oligonucleotides to inhibit the expression of isoprenyl protein transferases ZA955288B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413035A GB9413035D0 (en) 1994-06-29 1994-06-29 Antisense oligonucleeotides

Publications (1)

Publication Number Publication Date
ZA955288B true ZA955288B (en) 1996-01-31

Family

ID=10757497

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955288A ZA955288B (en) 1994-06-29 1995-06-26 Oligonucleotides to inhibit the expression of isoprenyl protein transferases

Country Status (25)

Country Link
US (1) US5856461A (sv)
EP (1) EP0692535A1 (sv)
JP (1) JPH0851985A (sv)
KR (1) KR960000914A (sv)
CN (1) CN1124142A (sv)
AU (1) AU689887B2 (sv)
BR (1) BR9503015A (sv)
CA (1) CA2152233A1 (sv)
CZ (1) CZ291496B6 (sv)
DZ (1) DZ1903A1 (sv)
FI (1) FI953170A (sv)
FR (2) FR2721827A1 (sv)
GB (2) GB9413035D0 (sv)
HU (1) HU219823B (sv)
IE (1) IE950477A1 (sv)
MA (1) MA23595A1 (sv)
NO (1) NO952601L (sv)
NZ (1) NZ272398A (sv)
OA (1) OA10221A (sv)
PL (1) PL309384A1 (sv)
RU (1) RU2112766C1 (sv)
SE (1) SE9502259L (sv)
SK (1) SK83895A3 (sv)
TN (1) TNSN95068A1 (sv)
ZA (1) ZA955288B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2226623A1 (en) * 1995-07-13 1997-01-30 University Of Cincinnati Compounds useful in the treatment of neurofibromatosis
CN1301731A (zh) * 1999-12-24 2001-07-04 上海博德基因开发有限公司 一种新的多肽——多异戊二烯基合成酶蛋白9和编码这种多肽的多核苷酸
US20030157598A1 (en) * 2000-12-07 2003-08-21 Ramanathan Chandra S. Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney
US20030212017A1 (en) * 2002-05-10 2003-11-13 Isis Pharmaceuticals Inc. Antisense modulation of farnesyl transferase beta subunit expression
US7507808B2 (en) * 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
US8785409B2 (en) * 2007-01-30 2014-07-22 Geron Corporation Compounds having anti-adhesive effects on cancer cells
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4571421A (en) * 1979-11-05 1986-02-18 Genentech, Inc. Mammalian gene for microbial expression
US5004803A (en) * 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US5420245A (en) * 1990-04-18 1995-05-30 Board Of Regents, The University Of Texas Tetrapeptide-based inhibitors of farnesyl transferase
US5185248A (en) * 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
KR100242671B1 (ko) * 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
NZ244820A (en) * 1991-10-25 1994-01-26 Isis Pharmaceuticals Inc Oligonucleotide inhibitor of epstein-barr virus.
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA

Also Published As

Publication number Publication date
SK83895A3 (en) 1996-05-08
OA10221A (fr) 1997-09-19
FR2721930B1 (fr) 1997-01-03
FI953170A (sv) 1995-12-30
CZ291496B6 (cs) 2003-03-12
HU219823B (hu) 2001-08-28
US5856461A (en) 1999-01-05
FR2721827A1 (fr) 1996-01-05
FI953170A0 (sv) 1995-06-27
RU2112766C1 (ru) 1998-06-10
KR960000914A (ko) 1996-01-25
HUT72133A (en) 1996-03-28
GB2290791B (en) 1998-08-05
AU2329995A (en) 1996-01-11
TNSN95068A1 (fr) 1996-02-06
EP0692535A1 (fr) 1996-01-17
NZ272398A (en) 1996-04-26
MA23595A1 (fr) 1995-12-31
SE9502259L (sv) 1995-12-30
AU689887B2 (en) 1998-04-09
GB2290791A (en) 1996-01-10
GB9413035D0 (en) 1994-08-17
SE9502259D0 (sv) 1995-06-21
BR9503015A (pt) 1996-06-04
DZ1903A1 (fr) 2002-02-17
FR2721930A1 (fr) 1996-01-05
IE950477A1 (en) 1996-01-10
CA2152233A1 (en) 1995-12-30
NO952601L (no) 1996-01-02
JPH0851985A (ja) 1996-02-27
HU9501913D0 (en) 1995-08-28
PL309384A1 (en) 1996-01-08
CZ168895A3 (en) 1996-05-15
RU95110774A (ru) 1997-04-20
GB9513246D0 (en) 1995-09-06
CN1124142A (zh) 1996-06-12
NO952601D0 (no) 1995-06-28

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