EP1140121A4 - Cryogranulation of activated protein c - Google Patents

Cryogranulation of activated protein c

Info

Publication number
EP1140121A4
EP1140121A4 EP99935947A EP99935947A EP1140121A4 EP 1140121 A4 EP1140121 A4 EP 1140121A4 EP 99935947 A EP99935947 A EP 99935947A EP 99935947 A EP99935947 A EP 99935947A EP 1140121 A4 EP1140121 A4 EP 1140121A4
Authority
EP
European Patent Office
Prior art keywords
cryogranulation
activated protein
protein
activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99935947A
Other languages
German (de)
French (fr)
Other versions
EP1140121A1 (en
Inventor
Jeffrey Clayton Baker
Nancy Delores Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP1140121A1 publication Critical patent/EP1140121A1/en
Publication of EP1140121A4 publication Critical patent/EP1140121A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
EP99935947A 1998-07-31 1999-07-26 Cryogranulation of activated protein c Withdrawn EP1140121A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9496998P 1998-07-31 1998-07-31
US94969P 1998-07-31
PCT/US1999/016937 WO2000006179A1 (en) 1998-07-31 1999-07-26 Cryogranulation of activated protein c

Publications (2)

Publication Number Publication Date
EP1140121A1 EP1140121A1 (en) 2001-10-10
EP1140121A4 true EP1140121A4 (en) 2004-07-14

Family

ID=22248239

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99935947A Withdrawn EP1140121A4 (en) 1998-07-31 1999-07-26 Cryogranulation of activated protein c

Country Status (5)

Country Link
EP (1) EP1140121A4 (en)
JP (1) JP2003506006A (en)
AU (1) AU5131699A (en)
CA (1) CA2338766A1 (en)
WO (1) WO2000006179A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007143A1 (en) 1989-11-17 1991-05-30 Green Alan J Dental floss applicators
AUPR750501A0 (en) * 2001-09-05 2001-09-27 Gauci, Mark Products comprising quantum of bioparticles and method for production thereof
DK1697033T3 (en) * 2003-12-19 2011-06-27 Alk Abello As Method for cryogranulation and storage of allergens
WO2005058474A1 (en) 2003-12-19 2005-06-30 Alk-Abelló A/S Cryogranulation and storage method for active pharmaceutical agents
EP2403471A2 (en) * 2009-03-06 2012-01-11 Linde AG Method for formulating cosmetics
RU2638794C2 (en) 2009-11-02 2017-12-15 Мэннкайнд Корпорэйшн Method for pharmaceutical composition cryogranulation
EP2879666B1 (en) * 2012-08-01 2020-04-08 Tavakoli, Zahra Free flowing, frozen compositions comprising a therapeutic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SCHMIDT D J ET AL: "CRYOGRANULATION: A POTENTIAL NEW FINAL PROCESS FOR BULK DRUG SUBSTANCES", BIOPHARM, CLEVELAND,OH, US, April 1997 (1997-04-01), pages 28,30,32, XP002914615 *
See also references of WO0006179A1 *

Also Published As

Publication number Publication date
WO2000006179A1 (en) 2000-02-10
EP1140121A1 (en) 2001-10-10
JP2003506006A (en) 2003-02-18
AU5131699A (en) 2000-02-21
CA2338766A1 (en) 2000-02-10

Similar Documents

Publication Publication Date Title
EG23685A (en) Activated protein c formulations
GB9719879D0 (en) Protein
GB9703681D0 (en) Protein complemention
ZA983065B (en) Inhibitors of protein farnesyltranferase
HK1039158A1 (en) Nlk1-interacting proteins
EP1018551A4 (en) Megsin protein
EP1140121A4 (en) Cryogranulation of activated protein c
EP1012262A4 (en) Human frezzled-like protein
IL139873A0 (en) Angoistatin-binding protein
GB9715064D0 (en) Protein expression
GB9828704D0 (en) Proteins
GB9828880D0 (en) Protein
GB9720784D0 (en) Protein
GB9816337D0 (en) Proteins
AU2593199A (en) Human smn-like protein
AU4992099A (en) Human presenilin-associated protein
GB9812607D0 (en) Protein
GB9819038D0 (en) Protein
GB9809566D0 (en) Protein
EP1127066A4 (en) Modified proteins
GB9816335D0 (en) Proteins
GB0320970D0 (en) Proteins
GB9816336D0 (en) Proteins
AU6250599A (en) Human isre-binding protein
GB9823975D0 (en) Protein

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010131

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

A4 Supplementary search report drawn up and despatched

Effective date: 20040528

17Q First examination report despatched

Effective date: 20040811

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20041222