ZA9510027B - Pyrrole derivatives - Google Patents

Pyrrole derivatives

Info

Publication number
ZA9510027B
ZA9510027B ZA9510027A ZA9510027A ZA9510027B ZA 9510027 B ZA9510027 B ZA 9510027B ZA 9510027 A ZA9510027 A ZA 9510027A ZA 9510027 A ZA9510027 A ZA 9510027A ZA 9510027 B ZA9510027 B ZA 9510027B
Authority
ZA
South Africa
Prior art keywords
pyrrole derivatives
pyrrole
derivatives
Prior art date
Application number
ZA9510027A
Other languages
English (en)
Inventor
Jim W Barnett
Chakk S Ramesha
James P Dunn
C Elliott Sigal
Denis J Kertesz
Eric Brain Sjogren
Aaron B Miller
Dabid B Smith
David John Morgans Jr
Francisco X Talamas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA9510027B publication Critical patent/ZA9510027B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ZA9510027A 1994-12-01 1995-11-24 Pyrrole derivatives ZA9510027B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/347,915 US5622948A (en) 1994-12-01 1994-12-01 Pyrrole pyridazine and pyridazinone anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ZA9510027B true ZA9510027B (en) 1996-06-03

Family

ID=23365840

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9510027A ZA9510027B (en) 1994-12-01 1995-11-24 Pyrrole derivatives

Country Status (19)

Country Link
US (1) US5622948A (pt)
EP (1) EP0714895A1 (pt)
JP (1) JPH08208639A (pt)
KR (1) KR960022506A (pt)
CN (1) CN1066726C (pt)
AR (1) AR001771A1 (pt)
AU (1) AU3906295A (pt)
BR (1) BR9505610A (pt)
CA (1) CA2163490A1 (pt)
CO (1) CO4650183A1 (pt)
CZ (1) CZ316995A3 (pt)
FI (1) FI955783A (pt)
HU (1) HUT75117A (pt)
IL (1) IL116139A0 (pt)
MA (1) MA23735A1 (pt)
NO (1) NO954878L (pt)
PL (1) PL311536A1 (pt)
TR (1) TR199501528A1 (pt)
ZA (1) ZA9510027B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
CN1136197C (zh) * 1996-05-30 2004-01-28 霍夫曼-拉罗奇有限公司 新的哒嗪酮衍生物
CA2256609C (en) * 1996-05-30 2005-07-26 F. Hoffmann-La Roche Ag 5-aroylpyrrol-2-ylmethylarene derivatives as inhibitors of prostaglandin g/h synthase
IL133552A (en) * 1997-08-22 2005-12-18 Abbott Lab Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
WO1999010331A1 (en) * 1997-08-22 1999-03-04 Abbott Laboratories Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
US6307047B1 (en) * 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
CN100376560C (zh) * 1997-10-27 2008-03-26 雷迪实验室有限公司 新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
BR9914858A (pt) * 1998-10-27 2002-02-05 Abbott Lab Inibidores de biosìntese sintase h de endoperóxido de prostaglandina
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2004006836A2 (en) * 2002-07-11 2004-01-22 Merck & Co., Inc. Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
AU2008322676B9 (en) * 2007-11-15 2014-03-27 Msd Italia S.R.L. Pyridazinone derivatives as PARP inhibitors
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2527335B1 (en) 2011-04-26 2013-09-18 King Saud University Triazole compounds as anti-inflammatory agents
KR102233456B1 (ko) 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102233455B1 (ko) 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
WO2022159980A1 (en) * 2021-01-25 2022-07-28 Athos Therapeutics, Inc. Pharmaceutical compounds and methods of making and using the same

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Publication number Priority date Publication date Assignee Title
US2316942A (en) * 1937-12-27 1943-04-20 Schlumberger Well Surv Corp Apparatus for measuring temperatures in boreholes
US3586681A (en) * 1967-11-02 1971-06-22 Sandoz Ag 1,4,5,6-tetrahydropyridazines
US3726978A (en) * 1967-11-02 1973-04-10 Sandoz Ag Tetrahydropyridazines and pyridazinones as anti-inflammatory agents
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US4048191A (en) * 1975-06-27 1977-09-13 Mcneil Laboratories, Incorporated Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4247551A (en) * 1979-09-17 1981-01-27 Gruppo Lepetit S.P.A. N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
IT1150070B (it) * 1980-12-22 1986-12-10 Lepetit Spa Procedimento per preparare derivati n-pirrolipiridazinamminici
AU8509882A (en) * 1981-06-30 1983-01-06 Merck & Co., Inc. Tricyclic derivatives of substituted pyrrole acids
EP0088128A4 (en) * 1981-09-11 1984-04-06 Diamond Shamrock Corp ANTI-IGNITION AND ANALGETIC 4-PYRIDYLPYRIDAZINE (2H) -3-ONE.
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
GB8501372D0 (en) * 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
AU688282B2 (en) * 1992-09-22 1998-03-12 University Of Rochester Stably-transformed mammalian cells expressing a regulated, inflammatory cyclooxygenase
US5543297A (en) * 1992-12-22 1996-08-06 Merck Frosst Canada, Inc. Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
US5332736A (en) * 1993-11-01 1994-07-26 Ortho Pharmaceutical Corporation Anti-convulsant aroyl aminoacylpyrroles
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
KR102081455B1 (ko) * 2017-06-09 2020-04-28 선상규 다중브러시를 이용한 직류발전장치

Also Published As

Publication number Publication date
KR960022506A (ko) 1996-07-18
HUT75117A (en) 1997-04-28
HU9503384D0 (en) 1996-01-29
NO954878L (no) 1996-06-03
CO4650183A1 (es) 1998-09-03
US5622948A (en) 1997-04-22
PL311536A1 (en) 1996-06-10
NO954878D0 (no) 1995-11-30
FI955783A (fi) 1996-06-02
CN1132206A (zh) 1996-10-02
AU3906295A (en) 1996-06-06
TR199501528A1 (tr) 1996-11-21
FI955783A0 (fi) 1995-12-01
BR9505610A (pt) 1997-09-16
JPH08208639A (ja) 1996-08-13
CA2163490A1 (en) 1996-06-02
IL116139A0 (en) 1996-01-31
MA23735A1 (fr) 1996-07-01
CZ316995A3 (en) 1996-06-12
AR001771A1 (es) 1997-12-10
CN1066726C (zh) 2001-06-06
EP0714895A1 (en) 1996-06-05

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