ZA942781B - Method for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds. - Google Patents

Method for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds.

Info

Publication number
ZA942781B
ZA942781B ZA942781A ZA942781A ZA942781B ZA 942781 B ZA942781 B ZA 942781B ZA 942781 A ZA942781 A ZA 942781A ZA 942781 A ZA942781 A ZA 942781A ZA 942781 B ZA942781 B ZA 942781B
Authority
ZA
South Africa
Prior art keywords
nmr
concentration
subject
vivo measurement
xenobiotic compounds
Prior art date
Application number
ZA942781A
Other languages
English (en)
Inventor
Michael F Tweedle
Adrian D Nunn
Harry William Strauss
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA942781B publication Critical patent/ZA942781B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA942781A 1993-04-23 1994-04-21 Method for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds. ZA942781B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/052,959 US5468467A (en) 1993-04-23 1993-04-23 Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds

Publications (1)

Publication Number Publication Date
ZA942781B true ZA942781B (en) 1995-01-05

Family

ID=21981033

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA942781A ZA942781B (en) 1993-04-23 1994-04-21 Method for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds.

Country Status (15)

Country Link
US (2) US5468467A (zh)
EP (1) EP0621491B1 (zh)
JP (1) JPH07374A (zh)
KR (1) KR100359898B1 (zh)
CN (1) CN1094938A (zh)
AT (1) ATE221208T1 (zh)
AU (1) AU6061394A (zh)
CA (1) CA2119345C (zh)
CZ (1) CZ89894A3 (zh)
DE (1) DE69431016T2 (zh)
FI (1) FI941832A (zh)
HU (1) HUT69795A (zh)
IL (1) IL109115A (zh)
NO (1) NO941485L (zh)
ZA (1) ZA942781B (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753207A (en) * 1995-08-21 1998-05-19 Beth Israel Deaconess Medical Center, Inc. Use of paramagnetic compounds to measure temperature and pH in vivo
US6319678B1 (en) * 1998-06-26 2001-11-20 Panvera Corporation Process for glucuronidation screening
US20040146847A1 (en) * 1998-12-07 2004-07-29 Trubetskoy Olga V. Process for glucuronidation screening
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10230877A1 (de) * 2002-07-09 2004-02-12 Siemens Ag Kernspintomographiegerät mit einer Einrichtung zur graphischen Planung Kontrastmittel-gestützter angiographischer Messungen
ES2369903T3 (es) * 2003-01-23 2011-12-09 University Of Florida Research Foundation, Incorporated Método y aparato para la vertificación de la concentración intravenosa (iv) de fármacos usando aliento exhalado.
US7939058B2 (en) * 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis
US20080085563A1 (en) * 2006-10-10 2008-04-10 Idexx Laboratories, Inc. Detection of Gadolinium Chelates
US20080085562A1 (en) * 2006-10-10 2008-04-10 Idexx Laboratories, Inc. Detection of gadolinium chelates
KR100973063B1 (ko) * 2008-11-11 2010-07-29 경희대학교 산학협력단 층상 가돌리늄 히드록사이드 및 그를 포함하는 ｍｒｉ 조영제
JP5971677B2 (ja) * 2010-11-26 2016-08-17 東芝メディカルシステムズ株式会社 磁気共鳴診断装置、および、磁気共鳴スペクトロスコピーのデータ収集方法
EP2812716A4 (en) * 2012-02-08 2015-07-29 Anatech Advanced Nmr Algorithms Technologies Ltd APPARATUS AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD PARAMETERS
CA2870876C (en) * 2012-05-23 2019-10-01 Genentech, Inc. Selection method for therapeutic agents
CN103217530B (zh) * 2013-03-26 2015-01-28 南昌大学 一种基于顺磁纳米Fe-Co合金探针间接富集的NMR食源性致病菌快速检测方法
CN103217449B (zh) * 2013-03-26 2016-02-24 南昌大学 一种基于顺磁纳米Fe-Ni合金探针间接富集的NMR食源性致病菌快速检测方法
CN105765376A (zh) * 2013-11-13 2016-07-13 纳诺努德股份公司 用于对水流体中氮的定量测定的方法
FR3039767B1 (fr) * 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
US11406721B2 (en) 2016-02-22 2022-08-09 The Regents Of The University Of California Compositions and methods for imaging cell populations
WO2023234979A2 (en) * 2021-12-20 2023-12-07 The Regents Of The University Of California High field magnetometry with hyperpolarized nuclear spins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49103693A (zh) * 1973-02-02 1974-10-01
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4837604A (en) * 1986-04-18 1989-06-06 Hypres, Inc. Femtosecond three-terminal switch and vertical tunnel junction
US4875486A (en) * 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
DE3851442T2 (de) * 1987-06-23 1995-01-19 Nycomed Innovation Ab Verbesserungen bei der Bilderzeugung mittels magnetischer Resonanz.
US5234680A (en) * 1989-07-31 1993-08-10 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
US5100646A (en) * 1990-07-25 1992-03-31 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services NMR glomerular filtration test
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
US5250284A (en) * 1991-10-15 1993-10-05 Arnon Krongrad Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc

Also Published As

Publication number Publication date
EP0621491A2 (en) 1994-10-26
EP0621491A3 (en) 1995-06-07
JPH07374A (ja) 1995-01-06
KR940023442A (ko) 1994-11-17
HU9401166D0 (en) 1994-07-28
IL109115A0 (en) 1994-06-24
IL109115A (en) 1997-07-13
KR100359898B1 (ko) 2003-01-10
EP0621491B1 (en) 2002-07-24
FI941832A (fi) 1994-10-24
CA2119345C (en) 1999-10-26
CN1094938A (zh) 1994-11-16
ATE221208T1 (de) 2002-08-15
CZ89894A3 (en) 1995-02-15
US5468467A (en) 1995-11-21
NO941485D0 (no) 1994-04-22
AU6061394A (en) 1994-10-27
DE69431016D1 (de) 2002-08-29
CA2119345A1 (en) 1994-10-24
FI941832A0 (fi) 1994-04-20
US5603917A (en) 1997-02-18
NO941485L (no) 1994-10-24
DE69431016T2 (de) 2003-03-27
HUT69795A (en) 1995-09-28

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