DE69431016D1 - Verfahren zur "In-vivo"-Messung der Konzentration von xenobiotischen Verbindungen mittels magnetischer Kernresonanz - Google Patents

Verfahren zur "In-vivo"-Messung der Konzentration von xenobiotischen Verbindungen mittels magnetischer Kernresonanz

Info

Publication number
DE69431016D1
DE69431016D1 DE69431016T DE69431016T DE69431016D1 DE 69431016 D1 DE69431016 D1 DE 69431016D1 DE 69431016 T DE69431016 T DE 69431016T DE 69431016 T DE69431016 T DE 69431016T DE 69431016 D1 DE69431016 D1 DE 69431016D1
Authority
DE
Germany
Prior art keywords
vivo
concentration
magnetic resonance
measurement
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431016T
Other languages
English (en)
Other versions
DE69431016T2 (de
Inventor
Michael F Tweedle
Harry William Strauss
Adrian D Nunn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE69431016D1 publication Critical patent/DE69431016D1/de
Publication of DE69431016T2 publication Critical patent/DE69431016T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69431016T 1993-04-23 1994-04-20 Verfahren zur "In-vivo"-Messung der Konzentration von xenobiotischen Verbindungen mittels magnetischer Kernresonanz Expired - Fee Related DE69431016T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/052,959 US5468467A (en) 1993-04-23 1993-04-23 Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds

Publications (2)

Publication Number Publication Date
DE69431016D1 true DE69431016D1 (de) 2002-08-29
DE69431016T2 DE69431016T2 (de) 2003-03-27

Family

ID=21981033

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431016T Expired - Fee Related DE69431016T2 (de) 1993-04-23 1994-04-20 Verfahren zur "In-vivo"-Messung der Konzentration von xenobiotischen Verbindungen mittels magnetischer Kernresonanz

Country Status (15)

Country Link
US (2) US5468467A (de)
EP (1) EP0621491B1 (de)
JP (1) JPH07374A (de)
KR (1) KR100359898B1 (de)
CN (1) CN1094938A (de)
AT (1) ATE221208T1 (de)
AU (1) AU6061394A (de)
CA (1) CA2119345C (de)
CZ (1) CZ89894A3 (de)
DE (1) DE69431016T2 (de)
FI (1) FI941832A (de)
HU (1) HUT69795A (de)
IL (1) IL109115A (de)
NO (1) NO941485L (de)
ZA (1) ZA942781B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753207A (en) * 1995-08-21 1998-05-19 Beth Israel Deaconess Medical Center, Inc. Use of paramagnetic compounds to measure temperature and pH in vivo
US6319678B1 (en) * 1998-06-26 2001-11-20 Panvera Corporation Process for glucuronidation screening
US20040146847A1 (en) * 1998-12-07 2004-07-29 Trubetskoy Olga V. Process for glucuronidation screening
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10230877A1 (de) * 2002-07-09 2004-02-12 Siemens Ag Kernspintomographiegerät mit einer Einrichtung zur graphischen Planung Kontrastmittel-gestützter angiographischer Messungen
EP1610681B1 (de) * 2003-01-23 2011-10-05 University of Florida Research Foundation, Incorporated Verfahren und gerät zur überwachung der intravenösen konzentration von medikamenten mittels ausatemluft
US7939058B2 (en) * 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis
US20080085563A1 (en) * 2006-10-10 2008-04-10 Idexx Laboratories, Inc. Detection of Gadolinium Chelates
US20080085562A1 (en) * 2006-10-10 2008-04-10 Idexx Laboratories, Inc. Detection of gadolinium chelates
KR100973063B1 (ko) * 2008-11-11 2010-07-29 경희대학교 산학협력단 층상 가돌리늄 히드록사이드 및 그를 포함하는 ｍｒｉ 조영제
JP5971677B2 (ja) * 2010-11-26 2016-08-17 東芝メディカルシステムズ株式会社 磁気共鳴診断装置、および、磁気共鳴スペクトロスコピーのデータ収集方法
US10159413B2 (en) 2012-02-08 2018-12-25 Anatech Advanced Nmr Algorithms Technologies Ltd. Apparatus and method for non-invasive measurement of blood parameters
KR101843614B1 (ko) * 2012-05-23 2018-03-29 제넨테크, 인크. 치료제의 선택 방법
CN103217449B (zh) * 2013-03-26 2016-02-24 南昌大学 一种基于顺磁纳米Fe-Ni合金探针间接富集的NMR食源性致病菌快速检测方法
CN103217530B (zh) * 2013-03-26 2015-01-28 南昌大学 一种基于顺磁纳米Fe-Co合金探针间接富集的NMR食源性致病菌快速检测方法
WO2015070872A1 (en) * 2013-11-13 2015-05-21 Nanonord A/S A method for quantitative determination of nitrogen in an aqueous fluid
FR3039767B1 (fr) * 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
US11406721B2 (en) 2016-02-22 2022-08-09 The Regents Of The University Of California Compositions and methods for imaging cell populations
WO2023234979A2 (en) * 2021-12-20 2023-12-07 The Regents Of The University Of California High field magnetometry with hyperpolarized nuclear spins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49103693A (de) * 1973-02-02 1974-10-01
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4837604A (en) * 1986-04-18 1989-06-06 Hypres, Inc. Femtosecond three-terminal switch and vertical tunnel junction
US4875486A (en) * 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
ES2058714T3 (es) * 1987-06-23 1994-11-01 Nycomed Innovation Ab Mejoras introducidas en formacion de imagenes por resonancia magnetica.
US5234680A (en) * 1989-07-31 1993-08-10 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
US5100646A (en) * 1990-07-25 1992-03-31 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services NMR glomerular filtration test
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
US5250284A (en) * 1991-10-15 1993-10-05 Arnon Krongrad Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc

Also Published As

Publication number Publication date
CA2119345A1 (en) 1994-10-24
NO941485L (no) 1994-10-24
CZ89894A3 (en) 1995-02-15
DE69431016T2 (de) 2003-03-27
HU9401166D0 (en) 1994-07-28
KR940023442A (ko) 1994-11-17
NO941485D0 (no) 1994-04-22
ATE221208T1 (de) 2002-08-15
EP0621491B1 (de) 2002-07-24
US5603917A (en) 1997-02-18
FI941832A0 (fi) 1994-04-20
ZA942781B (en) 1995-01-05
HUT69795A (en) 1995-09-28
CN1094938A (zh) 1994-11-16
IL109115A0 (en) 1994-06-24
US5468467A (en) 1995-11-21
JPH07374A (ja) 1995-01-06
KR100359898B1 (ko) 2003-01-10
EP0621491A3 (de) 1995-06-07
FI941832A (fi) 1994-10-24
AU6061394A (en) 1994-10-27
IL109115A (en) 1997-07-13
EP0621491A2 (de) 1994-10-26
CA2119345C (en) 1999-10-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee