ZA935862B - New hydrazono-5Béta 14Béta-androstane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same - Google Patents

New hydrazono-5Béta 14Béta-androstane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same

Info

Publication number
ZA935862B
ZA935862B ZA935862A ZA935862A ZA935862B ZA 935862 B ZA935862 B ZA 935862B ZA 935862 A ZA935862 A ZA 935862A ZA 935862 A ZA935862 A ZA 935862A ZA 935862 B ZA935862 B ZA 935862B
Authority
ZA
South Africa
Prior art keywords
5béta
14béta
hydrazono
preparation
new
Prior art date
Application number
ZA935862A
Other languages
English (en)
Inventor
Alberto Cerri
Giuseppe Bianchi
Elena Folpini
Luigi Bernardi
Patrizia Ferrari
Piero Melloni
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ZA935862B publication Critical patent/ZA935862B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA935862A 1992-08-20 1993-08-12 New hydrazono-5Béta 14Béta-androstane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same ZA935862B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4227626A DE4227626C2 (de) 1992-08-20 1992-08-20 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ZA935862B true ZA935862B (en) 1994-03-09

Family

ID=6466001

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA935862A ZA935862B (en) 1992-08-20 1993-08-12 New hydrazono-5Béta 14Béta-androstane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same

Country Status (7)

Country Link
US (1) US5538960A (xx)
EP (1) EP0583606A3 (xx)
JP (1) JPH06184187A (xx)
KR (1) KR940003963A (xx)
CA (1) CA2103824A1 (xx)
DE (1) DE4227626C2 (xx)
ZA (1) ZA935862B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4420501A1 (de) 1994-06-13 1995-12-14 Sigma Tau Ind Farmaceuti Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
IT1279386B1 (it) * 1994-11-07 1997-12-10 Sigma Tau Ind Farmaceuti 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
CN103242406B (zh) * 2013-05-19 2016-10-05 广西师范学院 去氢表雄酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460509A (en) * 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
DD237170A1 (de) * 1984-01-04 1986-07-02 Inst Molekularbiologie Ak Verfahren zur herstellung herzwirksamer 14 beta-hydroxy-androstan-glykoside
US5380840A (en) * 1985-09-12 1995-01-10 The Upjohn Company Triazinylpiperazinyl steroids
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten

Also Published As

Publication number Publication date
DE4227626A1 (de) 1994-05-11
JPH06184187A (ja) 1994-07-05
DE4227626C2 (de) 1994-11-17
CA2103824A1 (en) 1994-02-21
EP0583606A2 (en) 1994-02-23
EP0583606A3 (en) 1995-04-05
KR940003963A (ko) 1994-03-14
US5538960A (en) 1996-07-23

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