ZA932309B - Morpholin- and thiomorpholin-4-ylamides - Google Patents

Morpholin- and thiomorpholin-4-ylamides

Info

Publication number
ZA932309B
ZA932309B ZA932309A ZA932309A ZA932309B ZA 932309 B ZA932309 B ZA 932309B ZA 932309 A ZA932309 A ZA 932309A ZA 932309 A ZA932309 A ZA 932309A ZA 932309 B ZA932309 B ZA 932309B
Authority
ZA
South Africa
Prior art keywords
ylamides
thiomorpholin
morpholin
Prior art date
Application number
ZA932309A
Other languages
English (en)
Inventor
Guido Bold
Alexander Faessler
Marc Lang
Peter Schneider
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA932309B publication Critical patent/ZA932309B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA932309A 1992-04-01 1993-03-31 Morpholin- and thiomorpholin-4-ylamides ZA932309B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH105292 1992-04-01

Publications (1)

Publication Number Publication Date
ZA932309B true ZA932309B (en) 1993-10-18

Family

ID=4201332

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA932309A ZA932309B (en) 1992-04-01 1993-03-31 Morpholin- and thiomorpholin-4-ylamides

Country Status (12)

Country Link
US (1) US5409927A (fr)
EP (1) EP0565484A3 (fr)
JP (1) JPH0649093A (fr)
KR (1) KR930021655A (fr)
AU (1) AU3562193A (fr)
CA (1) CA2093109A1 (fr)
FI (1) FI931415A (fr)
IL (1) IL105228A0 (fr)
MX (1) MX9301863A (fr)
NO (1) NO931242L (fr)
TW (1) TW217410B (fr)
ZA (1) ZA932309B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753652A (en) * 1991-07-03 1998-05-19 Novartis Corporation Antiretroviral hydrazine derivatives
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5679688A (en) 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
KR20020042333A (ko) * 2000-11-30 2002-06-05 이계준 프로테아제 억제 활성을 갖는 약학적 조성물
ATE533491T1 (de) 2004-09-21 2011-12-15 Trobio Ab Stabilisierte protease zusammensetzungen enthaltend eine serinprotease, morpholin-derivate und reversible serinprotease- inhibitoren
AU2005336535B2 (en) * 2005-09-22 2012-05-24 Trobio Ab Stabilized protease composition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
GB8322414D0 (en) * 1983-08-19 1983-09-21 Szelke M Renin inhibitors
EP0173481A3 (fr) * 1984-08-06 1988-12-21 The Upjohn Company Peptides
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
EP0245361A1 (fr) * 1985-11-15 1987-11-19 The Upjohn Company Nouveaux analogues de polypeptides inhibiteurs de renine contenant s-aryl-d-cysteinyle ou l-cysteinyle ou dl-cysteinyle, de l'acide 3-(arylthio) lactique ou des moities de 3-(arylthio)-alkyl
WO1988002374A2 (fr) * 1986-09-30 1988-04-07 The Upjohn Company Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
IL91307A0 (en) * 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0374097A3 (fr) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Emploi d'isostères de peptides en tant qu'inhibiteurs de protéase rétrovirale
EP0374098A3 (fr) * 1988-12-15 1991-05-02 Ciba-Geigy Ag Inhibiteurs de protéase rétrovirale
CA2010531A1 (fr) * 1989-03-06 1990-09-06 Werner Neidhart Derives d'acides amines
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
US5242903A (en) * 1989-08-05 1993-09-07 Bayer Aktiengesellschaft Renin inhibitors
CA2066644A1 (fr) * 1989-10-27 1991-04-28 Robert L. Heinrikson Methode de traitement du vih et d'autres retrovirus et composes utilises pour ce faire
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
CA2055685A1 (fr) * 1990-11-19 1992-05-20 Samuel L. Graham Inhibiteurs de la protease du vih ayant des substituts de polyether
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use

Also Published As

Publication number Publication date
EP0565484A2 (fr) 1993-10-13
TW217410B (fr) 1993-12-11
FI931415A (fi) 1993-10-02
NO931242L (no) 1993-10-04
CA2093109A1 (fr) 1993-10-02
NO931242D0 (no) 1993-03-31
EP0565484A3 (en) 1993-12-29
MX9301863A (es) 1994-02-28
KR930021655A (ko) 1993-11-22
AU3562193A (en) 1993-10-07
FI931415A0 (fi) 1993-03-29
US5409927A (en) 1995-04-25
IL105228A0 (en) 1993-07-08
JPH0649093A (ja) 1994-02-22

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