FI931415A - Morfolin- och tiomorfolin-4-ylamider - Google Patents

Morfolin- och tiomorfolin-4-ylamider Download PDF

Info

Publication number
FI931415A
FI931415A FI931415A FI931415A FI931415A FI 931415 A FI931415 A FI 931415A FI 931415 A FI931415 A FI 931415A FI 931415 A FI931415 A FI 931415A FI 931415 A FI931415 A FI 931415A
Authority
FI
Finland
Prior art keywords
ylamider
thiomorfolin
morfolin
och
och thiomorfolin
Prior art date
Application number
FI931415A
Other languages
English (en)
Other versions
FI931415A0 (fi
Inventor
Guido Bold
Alexander Faessler
Marc Lang
Peter Schneider
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI931415A0 publication Critical patent/FI931415A0/fi
Publication of FI931415A publication Critical patent/FI931415A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI931415A 1992-04-01 1993-03-29 Morfolin- och tiomorfolin-4-ylamider FI931415A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH105292 1992-04-01

Publications (2)

Publication Number Publication Date
FI931415A0 FI931415A0 (fi) 1993-03-29
FI931415A true FI931415A (fi) 1993-10-02

Family

ID=4201332

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931415A FI931415A (fi) 1992-04-01 1993-03-29 Morfolin- och tiomorfolin-4-ylamider

Country Status (12)

Country Link
US (1) US5409927A (fi)
EP (1) EP0565484A3 (fi)
JP (1) JPH0649093A (fi)
KR (1) KR930021655A (fi)
AU (1) AU3562193A (fi)
CA (1) CA2093109A1 (fi)
FI (1) FI931415A (fi)
IL (1) IL105228A0 (fi)
MX (1) MX9301863A (fi)
NO (1) NO931242L (fi)
TW (1) TW217410B (fi)
ZA (1) ZA932309B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753652A (en) * 1991-07-03 1998-05-19 Novartis Corporation Antiretroviral hydrazine derivatives
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
RU2126794C1 (ru) 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
KR20020042333A (ko) * 2000-11-30 2002-06-05 이계준 프로테아제 억제 활성을 갖는 약학적 조성물
EP1637141B1 (en) * 2004-09-21 2011-11-16 Trobio AB Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease
JP5080476B2 (ja) * 2005-09-22 2012-11-21 トルービオ・アーベー 安定化プロテアーゼ組成物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8322414D0 (en) * 1983-08-19 1983-09-21 Szelke M Renin inhibitors
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
WO1987002986A1 (en) * 1985-11-15 1987-05-21 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
WO1988002374A2 (en) * 1986-09-30 1988-04-07 The Upjohn Company Renin inhibitory peptides having novel c-terminal moieties
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
IL91307A0 (en) * 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0374098A3 (de) * 1988-12-15 1991-05-02 Ciba-Geigy Ag Retrovirale Proteasehemmer
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
US5242903A (en) * 1989-08-05 1993-09-07 Bayer Aktiengesellschaft Renin inhibitors
EP0497835A1 (en) * 1989-10-27 1992-08-12 The Upjohn Company Method for treating hiv and other retroviruses and compounds useful therefor
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
CA2055685A1 (en) * 1990-11-19 1992-05-20 Samuel L. Graham Hiv protease inhibitors having polyether substituents
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use

Also Published As

Publication number Publication date
EP0565484A3 (en) 1993-12-29
IL105228A0 (en) 1993-07-08
MX9301863A (es) 1994-02-28
TW217410B (fi) 1993-12-11
NO931242D0 (no) 1993-03-31
AU3562193A (en) 1993-10-07
US5409927A (en) 1995-04-25
KR930021655A (ko) 1993-11-22
ZA932309B (en) 1993-10-18
NO931242L (no) 1993-10-04
EP0565484A2 (de) 1993-10-13
FI931415A0 (fi) 1993-03-29
CA2093109A1 (en) 1993-10-02
JPH0649093A (ja) 1994-02-22

Similar Documents

Publication Publication Date Title
FI934449A0 (fi) Elektrisk anslutningsdonsystem
AT399443B (de) Sportschuh
BR9305745A (pt) Quebra-luz
DE59301902D1 (de) Kassenlade
FI933289A0 (fi) Saekerhetspapper
ATA236892A (de) Rotornut
FI931415A0 (fi) Morfolin- och tiomorfolin-4-ylamider
ATA227792A (de) Sportschuh
BR9301712A (pt) Aplainador
DE59301762D1 (de) Chlorethylsulfonylbenzaldehyde
DE59206388D1 (de) Kabeleckkanal
FI684U1 (fi) Staplingsanordning
BR9204204A (pt) Gabanto
FIU920156U0 (fi) Foerbindelsesteg
BR9203234A (pt) Sofa-mesa
BR9203235A (pt) Compactimer
BR9203563A (pt) Rotortranca
BR9204065A (pt) Soprocóptero
ATA25994A (de) Alpinski
BR9204074A (pt) Contramarco pre-moldano
SE9201410D0 (sv) Flaekthus
SE9201126D0 (sv) Kedjestaang
BR9202723A (pt) Pipex
BR9200554A (pt) Lixoduto
ATA58493A (de) Lochstein

Legal Events

Date Code Title Description
FD Application lapsed