ZA931133B - Process for preparing enantiomerically pure fluoronated epoxychromans - Google Patents

Process for preparing enantiomerically pure fluoronated epoxychromans

Info

Publication number
ZA931133B
ZA931133B ZA931133A ZA931133A ZA931133B ZA 931133 B ZA931133 B ZA 931133B ZA 931133 A ZA931133 A ZA 931133A ZA 931133 A ZA931133 A ZA 931133A ZA 931133 B ZA931133 B ZA 931133B
Authority
ZA
South Africa
Prior art keywords
hydrogen
epoxychromans
fluoronated
enantiomerically pure
preparing enantiomerically
Prior art date
Application number
ZA931133A
Other languages
English (en)
Inventor
David Bell
Michael Fedouloff
Gillian Turner
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA931133B publication Critical patent/ZA931133B/xx

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22Organic complexes
    • B01J31/2204Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208Oxygen, e.g. acetylacetonates
    • B01J31/2226Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/70Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
    • B01J2231/72Epoxidation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B01J2531/0252Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/70Complexes comprising metals of Group VII (VIIB) as the central metal
    • B01J2531/72Manganese

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pyrane Compounds (AREA)
ZA931133A 1992-02-20 1993-02-18 Process for preparing enantiomerically pure fluoronated epoxychromans ZA931133B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929203596A GB9203596D0 (en) 1992-02-20 1992-02-20 Novel process

Publications (1)

Publication Number Publication Date
ZA931133B true ZA931133B (en) 1994-06-03

Family

ID=10710733

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA931133A ZA931133B (en) 1992-02-20 1993-02-18 Process for preparing enantiomerically pure fluoronated epoxychromans

Country Status (12)

Country Link
EP (1) EP0626967B1 (de)
JP (1) JPH07504183A (de)
KR (1) KR100245205B1 (de)
AT (1) ATE251626T1 (de)
AU (1) AU675420B2 (de)
CA (1) CA2130481A1 (de)
DE (1) DE69333240T2 (de)
GB (1) GB9203596D0 (de)
MX (1) MX9300895A (de)
NZ (1) NZ249200A (de)
WO (1) WO1993017026A1 (de)
ZA (1) ZA931133B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI90343C (fi) * 1987-06-23 1994-01-25 Merck Patent Gmbh Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi
DE68921972T2 (de) * 1988-12-13 1995-11-16 Beecham Group Plc Benzopyran und verwandte Verbindungen.
ATE161538T1 (de) * 1990-03-21 1998-01-15 Res Corp Technologies Inc Chirale katalysatoren und dadurch katalysierte epoxydierungsreaktionen

Also Published As

Publication number Publication date
NZ249200A (en) 1996-06-25
WO1993017026A1 (en) 1993-09-02
KR100245205B1 (ko) 2000-03-02
MX9300895A (es) 1994-08-31
DE69333240T2 (de) 2004-08-05
JPH07504183A (ja) 1995-05-11
GB9203596D0 (en) 1992-04-08
AU675420B2 (en) 1997-02-06
CA2130481A1 (en) 1993-09-02
AU3509593A (en) 1993-09-13
ATE251626T1 (de) 2003-10-15
DE69333240D1 (de) 2003-11-13
KR950700306A (ko) 1995-01-16
EP0626967A1 (de) 1994-12-07
EP0626967B1 (de) 2003-10-08

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