ZA927211B - Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. - Google Patents

Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.

Info

Publication number
ZA927211B
ZA927211B ZA927211A ZA927211A ZA927211B ZA 927211 B ZA927211 B ZA 927211B ZA 927211 A ZA927211 A ZA 927211A ZA 927211 A ZA927211 A ZA 927211A ZA 927211 B ZA927211 B ZA 927211B
Authority
ZA
South Africa
Prior art keywords
alkyl
hydrogen
enkephalinase
ace
inhibitors
Prior art date
Application number
ZA927211A
Other languages
English (en)
Inventor
Alan M Warshawsky
Gary Alan Flynn
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA927211B publication Critical patent/ZA927211B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA927211A 1991-09-27 1992-09-21 Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. ZA927211B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76728191A 1991-09-27 1991-09-27

Publications (1)

Publication Number Publication Date
ZA927211B true ZA927211B (en) 1993-03-24

Family

ID=25079018

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927211A ZA927211B (en) 1991-09-27 1992-09-21 Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.

Country Status (17)

Country Link
US (1) US5472959A (es)
EP (1) EP0534492B1 (es)
JP (1) JP3173673B2 (es)
KR (1) KR100273734B1 (es)
AT (1) ATE146482T1 (es)
AU (1) AU657794B2 (es)
CA (1) CA2078759C (es)
DE (1) DE69216026T2 (es)
DK (1) DK0534492T3 (es)
ES (1) ES2097847T3 (es)
FI (1) FI101304B1 (es)
GR (1) GR3022654T3 (es)
HU (1) HU214596B (es)
IL (1) IL103265A (es)
NO (1) NO300844B1 (es)
NZ (1) NZ244442A (es)
ZA (1) ZA927211B (es)

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US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
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US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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Also Published As

Publication number Publication date
HUT65174A (en) 1994-05-02
KR930006026A (ko) 1993-04-20
FI101304B (fi) 1998-05-29
DK0534492T3 (da) 1997-01-06
EP0534492B1 (en) 1996-12-18
IL103265A (en) 1996-09-12
AU2524792A (en) 1993-04-01
HU9203076D0 (en) 1992-12-28
GR3022654T3 (en) 1997-05-31
HU214596B (hu) 1998-04-28
EP0534492A3 (en) 1993-06-09
ATE146482T1 (de) 1997-01-15
CA2078759A1 (en) 1993-03-28
NO300844B1 (no) 1997-08-04
DE69216026T2 (de) 1997-07-17
NO923743D0 (no) 1992-09-25
AU657794B2 (en) 1995-03-23
FI924312A (fi) 1993-03-28
EP0534492A2 (en) 1993-03-31
IL103265A0 (en) 1993-02-21
ES2097847T3 (es) 1997-04-16
JP3173673B2 (ja) 2001-06-04
JPH05213950A (ja) 1993-08-24
DE69216026D1 (de) 1997-01-30
FI924312A0 (fi) 1992-09-25
CA2078759C (en) 2003-09-16
FI101304B1 (fi) 1998-05-29
NO923743L (no) 1993-03-29
KR100273734B1 (ko) 2001-02-01
NZ244442A (en) 1995-01-27
US5472959A (en) 1995-12-05

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