ZA924080B - A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production - Google Patents

A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production

Info

Publication number
ZA924080B
ZA924080B ZA924080A ZA924080A ZA924080B ZA 924080 B ZA924080 B ZA 924080B ZA 924080 A ZA924080 A ZA 924080A ZA 924080 A ZA924080 A ZA 924080A ZA 924080 B ZA924080 B ZA 924080B
Authority
ZA
South Africa
Prior art keywords
insulin
molecules
provides
proinsulin
intermediates
Prior art date
Application number
ZA924080A
Other languages
English (en)
Inventor
Rama M Belagaje
Richard Dennis Dimarchi
William Francis Heath Jr
Harlan Beall Long
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA924080B publication Critical patent/ZA924080B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA924080A 1991-06-11 1992-06-04 A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production ZA924080B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/715,183 US5304473A (en) 1991-06-11 1991-06-11 A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production

Publications (1)

Publication Number Publication Date
ZA924080B true ZA924080B (en) 1993-12-06

Family

ID=24872995

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA924080A ZA924080B (en) 1991-06-11 1992-06-04 A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production

Country Status (23)

Country Link
US (1) US5304473A (ja)
EP (1) EP0518587B1 (ja)
JP (1) JPH05255392A (ja)
KR (1) KR930000536A (ja)
CN (1) CN1068501A (ja)
AT (1) ATE166106T1 (ja)
AU (1) AU648670B2 (ja)
BR (1) BR9202180A (ja)
CA (1) CA2070503C (ja)
CZ (1) CZ171492A3 (ja)
DE (1) DE69225432T2 (ja)
DK (1) DK0518587T3 (ja)
ES (1) ES2116315T3 (ja)
FI (1) FI922645A (ja)
HU (1) HUT63193A (ja)
IE (1) IE921862A1 (ja)
IL (1) IL102107A0 (ja)
MX (1) MX9202726A (ja)
NO (1) NO922224L (ja)
NZ (1) NZ243089A (ja)
SK (1) SK171492A3 (ja)
YU (1) YU59392A (ja)
ZA (1) ZA924080B (ja)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
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US5378613A (en) * 1991-09-24 1995-01-03 Eli Lilly And Company Method for increased expression of low molecular weight recombinant polypeptides
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JP3954091B2 (ja) * 1993-06-21 2007-08-08 ジェネンテック・インコーポレーテッド リラキシンの製造方法
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5576197A (en) * 1995-04-07 1996-11-19 Molecular Bio-Products Polymerase chain reaction container and methods of using the same
AU5724996A (en) * 1995-05-05 1996-11-21 Eli Lilly And Company Single chain insulin with high bioactivity
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
AU2001266557A1 (en) * 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US7790690B2 (en) 2000-10-11 2010-09-07 U.S. Department Of Veterans Affairs Glucose sensitive regulator of insulin transcription
WO2002051428A1 (fr) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Composition de parfum stimulant le systeme sympathique
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7105314B2 (en) * 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
EP2990417A1 (en) 2001-12-21 2016-03-02 Human Genome Sciences, Inc. Albumin insulin fusion protein
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20050026826A1 (en) * 2003-01-17 2005-02-03 Margarethe Hoenig Feline proinsulin, insulin and constituent peptides
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN102816228A (zh) 2003-12-03 2012-12-12 诺和诺德公司 单链胰岛素
UA91512C2 (ru) * 2004-07-19 2010-08-10 Биокон Лимитед Коньюгати олигомеров инсулина, их композиция (варианты) и применение
US20090099095A1 (en) * 2007-05-16 2009-04-16 Peter Eriksson Novel neuroprotective peptide
JP5868594B2 (ja) * 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
WO2013004607A1 (en) * 2011-07-01 2013-01-10 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
EP2925345B1 (en) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
CA2924743A1 (en) 2013-10-04 2015-04-09 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
EP3666792A3 (en) 2014-11-21 2020-07-29 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
US11058775B2 (en) 2016-04-26 2021-07-13 Merck Sharp & Dohme Corp. Insulin dimer-incretin conjugates
US10953076B2 (en) 2016-05-24 2021-03-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists and GLP-1 analogues
EP3463413A4 (en) 2016-05-25 2020-03-04 Merck Sharp & Dohme Corp. PARTIAL INSULIN RECEPTOR AGONISTS
EP3272877A1 (en) 2016-07-18 2018-01-24 ETH Zurich B-cell-mimetic cells
CN109563487A (zh) 2016-07-18 2019-04-02 苏黎士联邦理工大学 β细胞拟似细胞
BR112019004314A2 (pt) 2016-09-06 2019-05-28 Chemical & Biopharmaceutical Laboratories Of Patras S A derivados pró-insulina
EP3600381A4 (en) 2017-03-23 2021-06-16 Merck Sharp & Dohme Corp. GLUCOSE-ACTIVE INSULIN WITH A THREE-VALUE SUGAR CLUSTER FOR THE TREATMENT OF DIABETES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
JPH04502465A (ja) * 1988-12-23 1992-05-07 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシュリン類似物質
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
IE921862A1 (en) 1992-12-16
CN1068501A (zh) 1993-02-03
EP0518587B1 (en) 1998-05-13
NO922224L (no) 1992-12-14
EP0518587A2 (en) 1992-12-16
ATE166106T1 (de) 1998-05-15
MX9202726A (es) 1992-12-01
EP0518587A3 (en) 1993-12-01
JPH05255392A (ja) 1993-10-05
NO922224D0 (no) 1992-06-05
FI922645A0 (fi) 1992-06-08
NZ243089A (en) 1994-01-26
HU9201915D0 (en) 1992-08-28
SK171492A3 (en) 1995-04-12
DE69225432T2 (de) 1998-10-01
AU648670B2 (en) 1994-04-28
YU59392A (sh) 1994-11-15
CZ171492A3 (en) 1993-05-12
AU1806992A (en) 1993-03-11
CA2070503A1 (en) 1992-12-12
ES2116315T3 (es) 1998-07-16
KR930000536A (ko) 1993-01-15
DE69225432D1 (de) 1998-06-18
US5304473A (en) 1994-04-19
IL102107A0 (en) 1993-01-14
CA2070503C (en) 1999-01-12
FI922645A (fi) 1992-12-12
HUT63193A (en) 1993-07-28
BR9202180A (pt) 1993-02-02
DK0518587T3 (da) 1998-10-19

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