ZA913359B - Stabilization of somatotropins and other proteins by modification of cysteine residues - Google Patents
Stabilization of somatotropins and other proteins by modification of cysteine residuesInfo
- Publication number
- ZA913359B ZA913359B ZA913359A ZA913359A ZA913359B ZA 913359 B ZA913359 B ZA 913359B ZA 913359 A ZA913359 A ZA 913359A ZA 913359 A ZA913359 A ZA 913359A ZA 913359 B ZA913359 B ZA 913359B
- Authority
- ZA
- South Africa
- Prior art keywords
- proteins
- polypeptides
- cysteine residues
- somatotropins
- stabilization
- Prior art date
Links
- 235000018102 proteins Nutrition 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 title abstract 2
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51904790A | 1990-05-04 | 1990-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA913359B true ZA913359B (en) | 1992-03-25 |
Family
ID=24066559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA913359A ZA913359B (en) | 1990-05-04 | 1991-05-03 | Stabilization of somatotropins and other proteins by modification of cysteine residues |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0458064B1 (ko) |
| JP (1) | JPH069696A (ko) |
| KR (1) | KR100213455B1 (ko) |
| AT (1) | ATE163431T1 (ko) |
| AU (1) | AU639324B2 (ko) |
| CA (1) | CA2041742A1 (ko) |
| DE (1) | DE69128944T2 (ko) |
| DK (1) | DK0458064T3 (ko) |
| ES (1) | ES2113354T3 (ko) |
| FI (1) | FI912144A (ko) |
| GR (1) | GR3026436T3 (ko) |
| IE (1) | IE911511A1 (ko) |
| IL (1) | IL97932A (ko) |
| NO (1) | NO911752L (ko) |
| NZ (1) | NZ237959A (ko) |
| PT (1) | PT97539B (ko) |
| ZA (1) | ZA913359B (ko) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
| AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| US5336488A (en) * | 1991-08-07 | 1994-08-09 | American Cyanamid Company | Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines |
| AU666914B2 (en) * | 1991-12-10 | 1996-02-29 | Tanox Biosystems, Inc. | Cytokines with an unpaired cysteine residue and conjugates thereof |
| JPH08506095A (ja) * | 1992-11-25 | 1996-07-02 | アムジェン ボールダー インコーポレイテッド | 改変インシュリン様成長因子 |
| EP0622394A1 (en) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use |
| US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
| AU2008202371B2 (en) * | 1999-01-14 | 2012-08-02 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| ATE367398T1 (de) | 2000-05-16 | 2007-08-15 | Bolder Biotechnology Inc | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
| WO2002055532A2 (en) * | 2001-01-11 | 2002-07-18 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
| JP2005525302A (ja) * | 2001-11-20 | 2005-08-25 | ファルマシア・コーポレーション | 化学的に修飾されたヒト成長ホルモンコンジュゲート |
| BR0317742A (pt) | 2002-12-26 | 2005-11-22 | Mountain View Pharmaceuticals | Conjugados poliméricos de interferon-beta com potência biológica aumentada |
| EP1673464A2 (en) * | 2003-10-10 | 2006-06-28 | Novo Nordisk A/S | Conjugation of peptides |
| US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| WO2007041614A2 (en) | 2005-10-03 | 2007-04-12 | Bolder Biotechnology, Inc. | Long acting vegf inhibitors and methods of use |
| EP2102355B1 (en) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
| SI2525834T1 (sl) | 2010-01-22 | 2019-10-30 | Novo Nordisk Healthcare Ag | Rastni hormoni s podaljšano in vivo učinkovitostjo |
| JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2514950B2 (ja) * | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質，その製造法および中間体 |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| EP0355460B1 (en) * | 1988-08-24 | 2000-12-27 | American Cyanamid Company | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
-
1991
- 1991-04-18 DK DK91106224.8T patent/DK0458064T3/da active
- 1991-04-18 DE DE69128944T patent/DE69128944T2/de not_active Expired - Fee Related
- 1991-04-18 EP EP91106224A patent/EP0458064B1/en not_active Expired - Lifetime
- 1991-04-18 ES ES91106224T patent/ES2113354T3/es not_active Expired - Lifetime
- 1991-04-18 AT AT91106224T patent/ATE163431T1/de not_active IP Right Cessation
- 1991-04-24 IL IL97932A patent/IL97932A/en not_active IP Right Cessation
- 1991-04-26 NZ NZ237959A patent/NZ237959A/en unknown
- 1991-04-29 AU AU76075/91A patent/AU639324B2/en not_active Ceased
- 1991-05-02 PT PT97539A patent/PT97539B/pt not_active IP Right Cessation
- 1991-05-02 CA CA002041742A patent/CA2041742A1/en not_active Abandoned
- 1991-05-02 JP JP3128190A patent/JPH069696A/ja active Pending
- 1991-05-03 IE IE151191A patent/IE911511A1/en not_active Application Discontinuation
- 1991-05-03 NO NO91911752A patent/NO911752L/no unknown
- 1991-05-03 ZA ZA913359A patent/ZA913359B/xx unknown
- 1991-05-03 KR KR1019910007216A patent/KR100213455B1/ko not_active IP Right Cessation
- 1991-05-03 FI FI912144A patent/FI912144A/fi not_active Application Discontinuation
-
1998
- 1998-03-24 GR GR970403459T patent/GR3026436T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU639324B2 (en) | 1993-07-22 |
| KR910020032A (ko) | 1991-12-19 |
| KR100213455B1 (ko) | 1999-08-02 |
| IE911511A1 (en) | 1991-11-06 |
| NZ237959A (en) | 1994-05-26 |
| JPH069696A (ja) | 1994-01-18 |
| EP0458064A2 (en) | 1991-11-27 |
| NO911752L (no) | 1991-11-05 |
| EP0458064B1 (en) | 1998-02-25 |
| AU7607591A (en) | 1991-11-07 |
| DK0458064T3 (da) | 1998-04-27 |
| IL97932A (en) | 1998-02-22 |
| PT97539B (pt) | 1998-08-31 |
| DE69128944T2 (de) | 1998-06-25 |
| EP0458064A3 (en) | 1992-06-17 |
| NO911752D0 (no) | 1991-05-03 |
| PT97539A (pt) | 1992-02-28 |
| ES2113354T3 (es) | 1998-05-01 |
| ATE163431T1 (de) | 1998-03-15 |
| FI912144A0 (fi) | 1991-05-03 |
| FI912144A (fi) | 1991-11-05 |
| IL97932A0 (en) | 1992-06-21 |
| CA2041742A1 (en) | 1991-11-05 |
| GR3026436T3 (en) | 1998-06-30 |
| DE69128944D1 (de) | 1998-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA913359B (en) | Stabilization of somatotropins and other proteins by modification of cysteine residues | |
| DE69027989T2 (de) | Il-3 MIT ZUSÄTZLICHEN CYSTEINRESTEN UND CHEMISCHE MODIFIKATIONEN DAVON | |
| FI910286A0 (fi) | Analoger av humant insulin och preparat innehaollande dessa. | |
| AU4020289A (en) | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis of chemical derivatization | |
| DE3675083D1 (de) | Material zum ausfuellen von periodontalen knochendefekten. | |
| NO954342L (no) | Erytropoietinanalogblandinger, samt fremgangsmåter ved fremstilling derav | |
| EP0564739A3 (ko) | ||
| ES2000216A6 (es) | Procedimiento para preparar un polipeptido purificado que tiene propiedades inhibidoras de la coagulacion de la sangre. | |
| FR2591485B1 (fr) | Compositions stabilisees contenant l'activateur du plasminogene du tissu humain. | |
| PT87111A (pt) | Process for the preparation of cyclic peptides and of pharmaceutical compositions containing the same | |
| NZ234501A (en) | Hemoregulatory peptides and pharmaceutical compositions containing them | |
| BR9307687A (pt) | Análogos de insulina | |
| IN172427B (ko) | ||
| MX9203175A (es) | Composicion de implante que contiene un peptido, polipeptido o proteina biologicamente activa y procedimiento para su preparacion. | |
| PT78571A (en) | Process for preparing biologically active polypeptides and of pharmaceutical compositions containing the same | |
| SE8200757L (sv) | Biologiskt aktiva peptider | |
| HUT52522A (en) | Process for producing imidazol-substituted peptide derivatives and pharmaceutical compositions containing them as active components | |
| DE3667472D1 (de) | Analoge von hypokalzemischen polypeptiden, welche den kalziumgehalt des koerpers schonen, deren herstellung, deren verwendung als arznei und diese enthaltende zusammensetzungen. | |
| WO1990003394A3 (fr) | Nouvelles lymphokines, sequences d'adn codant pour ces lymphokines et compositions pharmaceutiques contenant ces lymphokines | |
| SE9101586D0 (sv) | Modified thioredoxin and its use | |
| BR9006746A (pt) | Peptideo fisiologicamente ativo e agente regulador do metabolismo de calcio | |
| ES2061809T3 (es) | Un metodo para preparar un derivado de calcitonina. | |
| NO873751L (no) | Lymfocytt-aktiverende polypeptider. | |
| AU2125088A (en) | Solubilization of proteins for pharmaceutical compositions |