ZA908934B - Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors - Google Patents

Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors

Info

Publication number
ZA908934B
ZA908934B ZA908934A ZA908934A ZA908934B ZA 908934 B ZA908934 B ZA 908934B ZA 908934 A ZA908934 A ZA 908934A ZA 908934 A ZA908934 A ZA 908934A ZA 908934 B ZA908934 B ZA 908934B
Authority
ZA
South Africa
Prior art keywords
proteinkinase
pyridyloxazole
inhibitors
novel
ones useful
Prior art date
Application number
ZA908934A
Other languages
English (en)
Inventor
Hsien Chang Cheng
Chang Cheng Hsien
Richard Cyrus Dage
Cyrus Dage Richard
Winton Dennis Jones
Dennis Jones Winton
Phillip James Robinson
James Robinson Phillip
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA908934B publication Critical patent/ZA908934B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA908934A 1989-11-13 1990-11-07 Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors ZA908934B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43531489A 1989-11-13 1989-11-13

Publications (1)

Publication Number Publication Date
ZA908934B true ZA908934B (en) 1991-08-28

Family

ID=23727893

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908934A ZA908934B (en) 1989-11-13 1990-11-07 Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors

Country Status (5)

Country Link
EP (1) EP0428106A1 (xx)
JP (1) JPH03170477A (xx)
KR (1) KR910009679A (xx)
IE (1) IE904078A1 (xx)
ZA (1) ZA908934B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2915392A (en) * 1991-12-02 1993-06-28 Merrell Dow Pharmaceuticals Inc. Inhibition of angiogenesis with pyridinyloxazole-2-ones
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935902A1 (de) * 1979-09-05 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln Oxazolinalkansaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4698353A (en) * 1985-11-13 1987-10-06 Merrell Dow Pharmaceuticals Inc. Cardiotonic heterocyclic oxazolones
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 K−252誘導体

Also Published As

Publication number Publication date
IE904078A1 (en) 1991-05-22
EP0428106A1 (en) 1991-05-22
KR910009679A (ko) 1991-06-28
JPH03170477A (ja) 1991-07-24

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