ZA906720B - Process for the preparation of methylenebisphosphonic acids - Google Patents
Process for the preparation of methylenebisphosphonic acidsInfo
- Publication number
- ZA906720B ZA906720B ZA906720A ZA906720A ZA906720B ZA 906720 B ZA906720 B ZA 906720B ZA 906720 A ZA906720 A ZA 906720A ZA 906720 A ZA906720 A ZA 906720A ZA 906720 B ZA906720 B ZA 906720B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- preparation
- methylenebisphosphonic
- sec
- formula
- Prior art date
Links
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Control Of El Displays (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI894245A FI83657C (fi) | 1989-09-08 | 1989-09-08 | Foerfarande foer framstaellning av metylenbisfosfonsyror. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA906720B true ZA906720B (en) | 1991-06-26 |
Family
ID=8528962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA906720A ZA906720B (en) | 1989-09-08 | 1990-08-23 | Process for the preparation of methylenebisphosphonic acids |
Country Status (16)
Country | Link |
---|---|
US (1) | US5237094A (xx) |
EP (1) | EP0490907B1 (xx) |
JP (1) | JP2835651B2 (xx) |
AT (1) | ATE115957T1 (xx) |
AU (1) | AU640884B2 (xx) |
CA (1) | CA2066430C (xx) |
DE (1) | DE69015363T2 (xx) |
DK (1) | DK0490907T3 (xx) |
ES (1) | ES2067040T3 (xx) |
FI (1) | FI83657C (xx) |
HK (1) | HK1007560A1 (xx) |
NO (1) | NO180378C (xx) |
NZ (1) | NZ234965A (xx) |
RU (1) | RU2041230C1 (xx) |
WO (1) | WO1991003480A1 (xx) |
ZA (1) | ZA906720B (xx) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9903345D0 (sv) | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA777769A (en) * | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
US3683080A (en) | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
DE2229087B2 (de) * | 1972-06-15 | 1977-02-10 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von phosphon- und phosphinsaeuren durch verseifung von phosphon- und phosphinsaeureestern |
DE2813121A1 (de) | 1977-03-29 | 1978-10-12 | Procter & Gamble | Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung |
IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
IT1200462B (it) * | 1985-04-30 | 1989-01-18 | Gentili Ist Spa | Procedimento d'idrolisi degli esteri di acidi metilendifosfonici sostituiti |
US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
-
1989
- 1989-09-08 FI FI894245A patent/FI83657C/fi not_active IP Right Cessation
-
1990
- 1990-08-15 AT AT90912071T patent/ATE115957T1/de not_active IP Right Cessation
- 1990-08-15 EP EP90912071A patent/EP0490907B1/en not_active Expired - Lifetime
- 1990-08-15 JP JP2511215A patent/JP2835651B2/ja not_active Expired - Fee Related
- 1990-08-15 CA CA002066430A patent/CA2066430C/en not_active Expired - Fee Related
- 1990-08-15 DK DK90912071.9T patent/DK0490907T3/da active
- 1990-08-15 AU AU61582/90A patent/AU640884B2/en not_active Ceased
- 1990-08-15 WO PCT/FI1990/000197 patent/WO1991003480A1/en active IP Right Grant
- 1990-08-15 US US07/838,422 patent/US5237094A/en not_active Expired - Lifetime
- 1990-08-15 DE DE69015363T patent/DE69015363T2/de not_active Expired - Fee Related
- 1990-08-15 ES ES90912071T patent/ES2067040T3/es not_active Expired - Lifetime
- 1990-08-17 NZ NZ234965A patent/NZ234965A/xx unknown
- 1990-08-23 ZA ZA906720A patent/ZA906720B/xx unknown
-
1992
- 1992-03-06 NO NO920892A patent/NO180378C/no unknown
- 1992-03-06 RU SU925011701A patent/RU2041230C1/ru not_active IP Right Cessation
-
1998
- 1998-06-25 HK HK98106783A patent/HK1007560A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI83657B (fi) | 1991-04-30 |
JP2835651B2 (ja) | 1998-12-14 |
NO180378C (no) | 1997-04-09 |
DE69015363D1 (de) | 1995-02-02 |
CA2066430C (en) | 1999-02-02 |
AU6158290A (en) | 1991-04-08 |
FI894245A (fi) | 1991-03-09 |
NO920892D0 (no) | 1992-03-06 |
JPH05504943A (ja) | 1993-07-29 |
DE69015363T2 (de) | 1995-05-24 |
CA2066430A1 (en) | 1991-03-09 |
US5237094A (en) | 1993-08-17 |
FI894245A0 (fi) | 1989-09-08 |
DK0490907T3 (da) | 1995-05-08 |
WO1991003480A1 (en) | 1991-03-21 |
NO180378B (no) | 1996-12-30 |
ATE115957T1 (de) | 1995-01-15 |
FI83657C (fi) | 1991-08-12 |
EP0490907A1 (en) | 1992-06-24 |
AU640884B2 (en) | 1993-09-02 |
ES2067040T3 (es) | 1995-03-16 |
NZ234965A (en) | 1991-09-25 |
HK1007560A1 (en) | 1999-04-16 |
EP0490907B1 (en) | 1994-12-21 |
NO920892L (no) | 1992-03-06 |
RU2041230C1 (ru) | 1995-08-09 |
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