ZA901148B - Avermectin ketal derivatives useful as antiparasitic agents - Google Patents

Avermectin ketal derivatives useful as antiparasitic agents

Info

Publication number
ZA901148B
ZA901148B ZA901148A ZA901148A ZA901148B ZA 901148 B ZA901148 B ZA 901148B ZA 901148 A ZA901148 A ZA 901148A ZA 901148 A ZA901148 A ZA 901148A ZA 901148 B ZA901148 B ZA 901148B
Authority
ZA
South Africa
Prior art keywords
avermectin
antiparasitic agents
derivatives useful
ketal
ketal derivatives
Prior art date
Application number
ZA901148A
Other languages
English (en)
Inventor
Timothy A Blizzard
A Blizzard Timothy
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA901148B publication Critical patent/ZA901148B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA901148A 1989-02-16 1990-02-15 Avermectin ketal derivatives useful as antiparasitic agents ZA901148B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31126889A 1989-02-16 1989-02-16

Publications (1)

Publication Number Publication Date
ZA901148B true ZA901148B (en) 1990-10-31

Family

ID=23206158

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA901148A ZA901148B (en) 1989-02-16 1990-02-15 Avermectin ketal derivatives useful as antiparasitic agents

Country Status (11)

Country Link
US (1) US5077308A (fr)
EP (1) EP0388019B1 (fr)
JP (1) JPH02270880A (fr)
AT (1) ATE104983T1 (fr)
AU (1) AU623744B2 (fr)
CA (1) CA2010078A1 (fr)
DE (1) DE69008399T2 (fr)
DK (1) DK0388019T3 (fr)
ES (1) ES2063256T3 (fr)
NZ (1) NZ232422A (fr)
ZA (1) ZA901148B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119649A (en) * 1995-11-30 2002-03-10 Akzo Nobel Nv Preparation of Cyclic Kills of History - 3 keto- (5) 10, (-9) 11 steroidadians
EA002497B1 (ru) * 1997-12-03 2002-06-27 Мерк Энд Ко., Инк. Инъекционные композиции пролонгированного действия, содержащие гидрогенизированное касторовое масло
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US7001889B2 (en) * 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20060205681A1 (en) * 2002-06-21 2006-09-14 Maryam Moaddeb Homogenous paste formulations
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations
PL2035390T3 (pl) 2006-07-05 2016-06-30 Merial Inc Związki będące pochodnymi 1-arylo-5-alkilopirazolu, sposoby ich wytwarzania i zastosowania
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
SI3428148T1 (sl) 2007-05-15 2021-04-30 Boehringer Ingelheim Animal Health USA Inc. Ariloazol-2-il cianoetilamino spojine, postopek njihove izdelave in postopek njihove uporabe
ES2693696T3 (es) 2007-11-26 2018-12-13 Merial, Inc. Sistemas de disolventes para formulaciones de unción dorsal continua para combatir parásitos
CA2710171C (fr) 2007-12-21 2016-02-02 Merial Limited Utilisation de composes 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine dans la lutte contre les nuisibles chez l'animal
NZ590141A (en) * 2008-06-24 2012-05-25 Merial Ltd Anthelminthic formulations including castor oil and another vegetable oil
EA019606B1 (ru) 2008-11-14 2014-04-30 Мериал Лимитед Арилоазол-2-илцианоэтиламино соединения противопаразитарного действия, обогащенные одним из энантиомеров
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids
CN102271672B (zh) 2008-11-19 2015-02-04 梅里亚有限公司 用于治疗寄生物感染的包含单独的或与甲脒组合的1-芳基吡唑的组合物
US8426460B2 (en) 2008-12-04 2013-04-23 Merial Limited Dimeric avermectin and milbemycin derivatives
MX2012001170A (es) 2009-07-30 2012-07-20 Merial Ltd Compuestos de 4-amino-tieno [2,3-d]pirimidina insecticidas y metodos para su uso.
BR112012013482B1 (pt) 2009-12-04 2018-11-06 Basf Se compostos de bis-organossulfurados pesticidas
SG181679A1 (en) 2009-12-17 2012-07-30 Merial Ltd Anti parasitic dihydroazole compounds and compositions comprising same
US8980896B2 (en) 2009-12-17 2015-03-17 Merial, Inc. Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
AU2011252987B2 (en) 2010-05-12 2013-05-02 Boehringer Ingelheim Animal Health USA Inc. Injectable parasiticidal formulations of levamisole and macrocyclic lactones
WO2012054328A1 (fr) 2010-10-20 2012-04-26 Galderma S.A. Méthode de traitement des hémorroïdes à l'aide d'un composé de lactone macrocyclique
CA2811926A1 (fr) 2010-10-20 2012-04-26 Galderma S.A. Methode de traitement de l'otite externe a l'aide d'un compose de lactone macrocyclique
WO2012068202A1 (fr) 2010-11-16 2012-05-24 Merial Limited Nouveaux dérivés de monensine pour traitement et prévention d'infections protozoaires
WO2012078605A1 (fr) 2010-12-07 2012-06-14 Merial Limited Formulations de combinaison topiques de lactones macrocycliques avec des pyréthroïdes synthétiques
AU2012275435B2 (en) 2011-06-27 2016-07-21 Boehringer Ingelheim Animal Health USA Inc. Amido-pyridyl ether compounds and compositions and their use against parasites
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
PT2755473T (pt) 2011-09-12 2019-03-25 Boehringer Ingelheim Animal Health Usa Inc Composições parasiticidas compreendendo um agente ativo de isoxazolina, métodos e suas utilizações
WO2013044118A2 (fr) 2011-09-23 2013-03-28 Merial Limited Modélisation indirecte de molécules répulsives inédites actives contre les insectes, les acariens et autres arthropodes
JP6249568B2 (ja) 2011-11-17 2017-12-20 メリアル インコーポレイテッド アリールピラゾールと置換イミダゾールを含む組成物、その使用方法
DK3351546T5 (da) 2011-12-02 2024-08-12 Boehringer Ingelheim Vetmedica Gmbh Langtidsvirkende injicerbare moxidectinformuleringer
WO2013119442A1 (fr) 2012-02-06 2013-08-15 Merial Limited Compositions vétérinaires orales parasiticides comprenant des agents actifs à action systémique, procédés et utilisation associés
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
KR102160836B1 (ko) 2012-04-20 2020-09-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 벤즈이미다졸 유도체를 포함하는 구충 조성물, 방법 및 그의 용도
BR112015011441A2 (pt) 2012-11-20 2017-07-11 Merial Inc composições e compostos antihelmínticos e métodos de usos dos mesmos
AU2014212217B2 (en) 2013-01-31 2016-11-10 Boehringer Ingelheim Animal Health USA Inc. Method for treating and curing Leishmaniosis using fexinidazole
JP6484641B2 (ja) 2013-11-01 2019-03-13 メリアル インコーポレイテッド 駆虫性かつ殺有害生物性のイソオキサゾリン化合物
MX2016013573A (es) 2014-04-17 2017-02-13 Merial Inc Uso de compuestos de malononitrilo para proteger animales de parasitos.
AU2015264336B2 (en) 2014-05-19 2018-08-30 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds
CN106536481B (zh) 2014-06-19 2019-11-22 勃林格殷格翰动物保健美国公司 包含吲哚衍生物的杀寄生物的组合物、其用法和用途
WO2016069983A1 (fr) 2014-10-31 2016-05-06 Merial, Inc. Composition parasiticide comprenant du fipronil
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG11201708068PA (en) 2015-04-08 2017-10-30 Merial Inc Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
JP7045191B2 (ja) 2015-05-20 2022-03-31 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
WO2016191389A2 (fr) 2015-05-27 2016-12-01 Merial, Inc. Compositions contenant des anticorps igy antimicrobiens, pour le traitement et la prévention de troubles et de maladies causés par des micro-organismes compromettant la santé orale (ohc)
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (fr) 2016-08-25 2018-03-01 Merial, Inc. Procédé de réduction d'effets indésirables dans des traitements antiparasitaires
JP2019535655A (ja) 2016-10-14 2019-12-12 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物
JP2020504710A (ja) 2016-11-16 2020-02-13 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
US11147273B2 (en) 2017-06-26 2021-10-19 Boehringer Ingelheim Animal Health USA Inc. Dual active parasiticidal granule compositions, methods and uses thereof
EP3668866B1 (fr) 2017-08-14 2023-01-18 Boehringer Ingelheim Animal Health USA Inc. Composés de pyrazole-isoxazoline à activité pesticide et parasiticide
WO2019157241A1 (fr) 2018-02-08 2019-08-15 Boehringer Ingelheim Animal Health USA Inc. Compositions parasiticides comprenant de l'éprinomectine et du praziquantel, procédés et utilisations associés
EP3820870A1 (fr) 2018-07-09 2021-05-19 Boehringer Ingelheim Animal Health USA Inc. Composés hétérocycliques anthelminthiques
CN113260419A (zh) 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
WO2020150032A1 (fr) 2019-01-16 2020-07-23 Boehringer Ingelheim Animal Health USA Inc. Compositions topiques comprenant un néonicotinoïde et une lactone macrocyclique, procédés et utilisations associés
CN113507922A (zh) 2019-03-01 2021-10-15 勃林格殷格翰动物保健美国公司 可注射的氯舒隆组合物、其方法和用途
CA3133100A1 (fr) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Composes d'aza-benzothiophene et d'aza-benzofurane anthelminthiques
US20220323421A1 (en) 2019-07-22 2022-10-13 Intervet Inc. Soft Chewable Veterinary Dosage Form
JP2023528822A (ja) 2020-05-29 2023-07-06 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性複素環式化合物
EP4262789A1 (fr) 2020-12-21 2023-10-25 Boehringer Ingelheim Vetmedica GmbH Collier parasiticide comprenant des composés d'isoxazoline

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
USRE32006E (en) * 1977-12-19 1985-10-15 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
USRE32032E (en) * 1978-02-10 1985-11-19 Foam Cutting Engineers, Inc. Method of densifying open-celled polyurethane material
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
EP0170006B1 (fr) * 1984-06-05 1992-07-08 American Cyanamid Company Agents et leurs méthodes de production, méthodes et compositions contenant ces agents pour lutter contre les infections dûes aux helminthes, aux arthropodes, aux ectoparasites et aux acariens
IT1182857B (it) * 1984-09-14 1987-10-05 Glaxo Group Ltd Composti antibiotici, composizioni antiparassitarie che li contengono e procedimento per prepararli ed applicarli
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
EP0277916B1 (fr) * 1987-02-04 1994-05-25 Ciba-Geigy Ag Méthode microbienne de préparation de dérivés de la mylbémycide
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock

Also Published As

Publication number Publication date
EP0388019A1 (fr) 1990-09-19
JPH02270880A (ja) 1990-11-05
AU623744B2 (en) 1992-05-21
ES2063256T3 (es) 1995-01-01
AU4983090A (en) 1991-08-29
CA2010078A1 (fr) 1990-08-16
EP0388019B1 (fr) 1994-04-27
ATE104983T1 (de) 1994-05-15
DE69008399D1 (de) 1994-06-01
DE69008399T2 (de) 1994-10-27
DK0388019T3 (da) 1994-05-24
US5077308A (en) 1991-12-31
NZ232422A (en) 1992-11-25

Similar Documents

Publication Publication Date Title
ZA901148B (en) Avermectin ketal derivatives useful as antiparasitic agents
IL102616A0 (en) 1,3-oxathiolane nucleoside analogues,methods for the preparation thereof and pharmaceutical compositions containing the same
IL89921A0 (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
IL98025A0 (en) 1,3-oxathiolane nucleoside analogues,methods for the preparation thereof and pharmaceutical compositions containing the same
NZ227251A (en) Macrolide derivatives and pharmaceutical compositions
IL88765A (en) N-hydroxycycloalkyl or n-hydroxycycloalkenyl- substituted adenosine derivatives, methods for their preparation and pharmaceutical compositions, including antilipolytic compositions, containing the same
EG18127A (en) Compositions for combating pests containing macrocyclic lactones
ZA932981B (en) Avermectin difluoro derivatives
HUT54358A (en) Process for producing substituted 1,3,5-triazinetrione derivatives and medical compositions comprising such compounds as active ingredient
ZA908636B (en) 13-epi-avermectin derivatives useful as antiparasitic agents
OA09192A (en) "Stabilized sulfur dissolving compositions".
ZA881430B (fr)
CA2010982A1 (fr) Promotion de l'osteogenese par l'utilisation de derives de vitamine d
HUT52069A (en) Herbicide compositions containing sulfonanilide derivatives as active components and process for producing the active components
EP0305972A3 (fr) Dérivés du 3'-déméthoxyépipodophyllotoxine glucoside
CA2036507A1 (fr) Dihydrate de 2'-desoxy-2'-methylidiene cytidine, methodes de production et compositions
HUT52763A (en) Herbicide and growth-controlling compositions containing sulfonyl-urea derivatives as active components and process for producing the active components
HUT64339A (en) Process for producing pyrido/2,3-d/pyridazine-5/thi/on derivatives and herbvicidal compositions containing said compounds as active ingredients
AU2214092A (en) 13 beta-O-methoxymethyl-22,23-dihydro avermectin B1a/B1b aglycone as a superior antiparasitic agents
HUT56579A (en) Process for producing 19-norprogesterone derivatives alkylated at 17/21 position, as well as pharmaceutical compositions comprising such compounds as active ingredient
IL103856A0 (en) Aminoalkyl-substituted 5,6-dihydro-dibenz(b,e)azepin-6,11-dione-11-oximes,their preparation and pharmaceutical compositions containing them
HUT52762A (en) Herbicide compositions containing substituted sulfonyl-urea derivatives as active components and process for producing the active components
HUT50114A (en) Herbicide compositions containing halogeno-substituted phenoxy-benzyl-/thio/o/-derivatives as active component and process for producing these compounds
HUT52072A (en) Microbicide compositions containing new halogeno-vinyl-azol derivatives as active components, and process for producing the active components
HU902898D0 (en) Hiv-prevention by the synergetic combination of nucleosid derivatives