ZA9010269B - 2-formylbenzylphosphonic acid derivatives,their preparation and their use for the treatment of diseases caused by viruses - Google Patents
2-formylbenzylphosphonic acid derivatives,their preparation and their use for the treatment of diseases caused by virusesInfo
- Publication number
- ZA9010269B ZA9010269B ZA9010269A ZA9010269A ZA9010269B ZA 9010269 B ZA9010269 B ZA 9010269B ZA 9010269 A ZA9010269 A ZA 9010269A ZA 9010269 A ZA9010269 A ZA 9010269A ZA 9010269 B ZA9010269 B ZA 9010269B
- Authority
- ZA
- South Africa
- Prior art keywords
- viruses
- preparation
- treatment
- diseases caused
- alkynyl
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- URYYOODIPZFJIN-UHFFFAOYSA-N (2-formylphenyl)methylphosphonic acid Chemical class OP(O)(=O)CC1=CC=CC=C1C=O URYYOODIPZFJIN-UHFFFAOYSA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- -1 cyclic diester Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000000651 prodrug Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3942318A DE3942318A1 (de) | 1989-12-21 | 1989-12-21 | 2-formylbenzylphosphonsaeure-derivate, deren herstellung und ihre verwendung zur behandlung von durch viren verursachte krankheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9010269B true ZA9010269B (en) | 1991-09-25 |
Family
ID=6396038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9010269A ZA9010269B (en) | 1989-12-21 | 1990-12-20 | 2-formylbenzylphosphonic acid derivatives,their preparation and their use for the treatment of diseases caused by viruses |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0433928B1 (hu) |
| JP (1) | JP2997552B2 (hu) |
| KR (1) | KR100191087B1 (hu) |
| AT (1) | ATE119908T1 (hu) |
| AU (1) | AU640723B2 (hu) |
| CA (1) | CA2032772C (hu) |
| DE (2) | DE3942318A1 (hu) |
| FI (1) | FI102280B1 (hu) |
| HU (1) | HU208144B (hu) |
| IE (1) | IE67439B1 (hu) |
| IL (1) | IL96730A (hu) |
| NO (1) | NO179614C (hu) |
| NZ (1) | NZ236554A (hu) |
| PL (1) | PL288361A1 (hu) |
| PT (1) | PT96287B (hu) |
| RU (1) | RU2039063C1 (hu) |
| ZA (1) | ZA9010269B (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006335737A (ja) * | 2005-06-03 | 2006-12-14 | Ihara Nikkei Kagaku Kogyo Kk | ベンゾ［ｃ］ヘテロ５員環化合物の製造方法 |
| AU2006272521A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of HIV |
| JP5789430B2 (ja) | 2011-06-27 | 2015-10-07 | イハラニッケイ化学工業株式会社 | ２−クロロメチルベンズアルデヒドの製造方法、２−クロロメチルベンズアルデヒド含有組成物及びその保管方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918064A (en) * | 1987-10-21 | 1990-04-17 | G. D. Searle & Co. | Phenyl glycines for use in reducing neurotoxic injury |
-
1989
- 1989-12-21 DE DE3942318A patent/DE3942318A1/de not_active Withdrawn
-
1990
- 1990-12-15 EP EP90124305A patent/EP0433928B1/de not_active Expired - Lifetime
- 1990-12-15 AT AT90124305T patent/ATE119908T1/de not_active IP Right Cessation
- 1990-12-15 DE DE59008715T patent/DE59008715D1/de not_active Expired - Fee Related
- 1990-12-19 IL IL9673090A patent/IL96730A/en not_active IP Right Cessation
- 1990-12-19 NZ NZ236554A patent/NZ236554A/en unknown
- 1990-12-19 FI FI906268A patent/FI102280B1/fi not_active IP Right Cessation
- 1990-12-20 PL PL28836190A patent/PL288361A1/xx unknown
- 1990-12-20 ZA ZA9010269A patent/ZA9010269B/xx unknown
- 1990-12-20 IE IE462590A patent/IE67439B1/en not_active IP Right Cessation
- 1990-12-20 RU SU4894049/04A patent/RU2039063C1/ru not_active IP Right Cessation
- 1990-12-20 PT PT96287A patent/PT96287B/pt not_active IP Right Cessation
- 1990-12-20 CA CA002032772A patent/CA2032772C/en not_active Expired - Fee Related
- 1990-12-20 NO NO905521A patent/NO179614C/no unknown
- 1990-12-20 AU AU68304/90A patent/AU640723B2/en not_active Ceased
- 1990-12-20 JP JP2417963A patent/JP2997552B2/ja not_active Expired - Fee Related
- 1990-12-21 KR KR1019900021297A patent/KR100191087B1/ko not_active IP Right Cessation
- 1990-12-21 HU HU908412A patent/HU208144B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT96287A (pt) | 1991-09-30 |
| KR100191087B1 (ko) | 1999-06-15 |
| FI102280B (fi) | 1998-11-13 |
| EP0433928B1 (de) | 1995-03-15 |
| NO905521D0 (no) | 1990-12-20 |
| JPH0616685A (ja) | 1994-01-25 |
| IE904625A1 (en) | 1991-07-17 |
| NO905521L (no) | 1991-06-24 |
| ATE119908T1 (de) | 1995-04-15 |
| NO179614C (no) | 1996-11-13 |
| IE67439B1 (en) | 1996-04-03 |
| KR910011874A (ko) | 1991-08-07 |
| PL288361A1 (en) | 1992-07-13 |
| FI102280B1 (fi) | 1998-11-13 |
| FI906268A0 (fi) | 1990-12-19 |
| JP2997552B2 (ja) | 2000-01-11 |
| IL96730A0 (en) | 1991-09-16 |
| AU640723B2 (en) | 1993-09-02 |
| DE3942318A1 (de) | 1991-06-27 |
| PT96287B (pt) | 1998-06-30 |
| AU6830490A (en) | 1991-06-27 |
| DE59008715D1 (de) | 1995-04-20 |
| FI906268A (fi) | 1991-06-22 |
| NO179614B (no) | 1996-08-05 |
| CA2032772A1 (en) | 1991-06-22 |
| HU208144B (en) | 1993-08-30 |
| NZ236554A (en) | 1992-12-23 |
| HUT56111A (en) | 1991-07-29 |
| EP0433928A1 (de) | 1991-06-26 |
| IL96730A (en) | 1996-10-31 |
| RU2039063C1 (ru) | 1995-07-09 |
| CA2032772C (en) | 2001-10-23 |
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