ZA893578B - Novel hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition - Google Patents
Novel hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibitionInfo
- Publication number
- ZA893578B ZA893578B ZA893578A ZA893578A ZA893578B ZA 893578 B ZA893578 B ZA 893578B ZA 893578 A ZA893578 A ZA 893578A ZA 893578 A ZA893578 A ZA 893578A ZA 893578 B ZA893578 B ZA 893578B
- Authority
- ZA
- South Africa
- Prior art keywords
- cyclooxygenase
- nonsteroidal antiinflammatory
- acyl residues
- lipoxygenase inhibition
- hydroxamate derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/196,584 US4943587A (en) | 1988-05-19 | 1988-05-19 | Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA893578B true ZA893578B (en) | 1991-01-30 |
Family
ID=22725977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA893578A ZA893578B (en) | 1988-05-19 | 1989-05-12 | Novel hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition |
Country Status (11)
Country | Link |
---|---|
US (1) | US4943587A (ko) |
EP (1) | EP0342682A3 (ko) |
JP (1) | JPH0236163A (ko) |
KR (1) | KR890017233A (ko) |
AU (1) | AU623900B2 (ko) |
DK (1) | DK242389A (ko) |
FI (1) | FI892322A (ko) |
NO (1) | NO891951L (ko) |
NZ (1) | NZ229174A (ko) |
PT (1) | PT90602B (ko) |
ZA (1) | ZA893578B (ko) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5068251A (en) * | 1988-12-16 | 1991-11-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
AU4717889A (en) * | 1988-12-29 | 1990-07-05 | Ciba-Geigy Ag | Amino-substituted hydroxamic acids |
US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5840749A (en) * | 1989-08-25 | 1998-11-24 | Hoechst Marion Roussel, Inc. | N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues |
US5229516A (en) * | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5015481A (en) * | 1990-05-03 | 1991-05-14 | G. D. Searle & Co. | Stabilized pharmaceutical admixture composition |
US5097397A (en) * | 1990-10-04 | 1992-03-17 | Federal Signal Corporation | Non-linear signalling device for vehicles |
US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
US5594106A (en) * | 1993-08-23 | 1997-01-14 | Immunex Corporation | Inhibitors of TNF-α secretion |
US6063818A (en) * | 1996-06-13 | 2000-05-16 | Cell Pathways Inc. | Substituted benzylidene indenyl formamides, acetamides and propionamides |
US5998477A (en) * | 1996-06-13 | 1999-12-07 | Cell Pathways Inc. | Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions |
US5965619A (en) * | 1996-06-13 | 1999-10-12 | Cell Pathways Inc. | Method for treating patients having precancerous lesions with substituted indene derivatives |
US6121321A (en) * | 1996-06-13 | 2000-09-19 | Cell Pathways, Inc. | Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions |
US6071934A (en) * | 1997-03-25 | 2000-06-06 | Cell Pathways, Inc. | Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions |
US5948779A (en) * | 1997-12-12 | 1999-09-07 | Cell Pathways, Inc. | Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes |
US6028116A (en) * | 1998-04-03 | 2000-02-22 | Cell Pathways, Inc. | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia |
US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
JP4790594B2 (ja) | 2003-02-25 | 2011-10-12 | トポターゲット ユーケー リミテッド | Hdacインヒビターとしての、二環式ヘテロアリール基を含むヒドロキサム酸化合物 |
WO2004087051A2 (en) | 2003-03-27 | 2004-10-14 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
AU2005244770A1 (en) | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
NZ555247A (en) * | 2004-12-23 | 2010-06-25 | Roxro Pharma Inc | Therapeutic compositions for intranasal administration of ketorolac |
WO2007149456A2 (en) | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
MX2010013484A (es) * | 2008-06-13 | 2011-03-29 | Roxro Pharma Inc Star | Formulaciones en dosis unitaria de ketorolaco para administración intra-nasal. |
US8551454B2 (en) * | 2009-03-13 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
US8277781B2 (en) * | 2009-03-13 | 2012-10-02 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
KR101357438B1 (ko) | 2009-04-29 | 2014-02-06 | 아마린 코포레이션 피엘씨 | Epa 및 심혈관 제제를 포함하는 제약 조성물 및 그의 사용 방법 |
CA2676946A1 (en) * | 2009-08-28 | 2011-02-28 | Lucie Peduto | Adam12 inhibitors and their use against inflammation-induced fibrosis |
EP2768499A4 (en) | 2011-10-17 | 2015-08-26 | Univ Vanderbilt | INDOMETACIN ANALOGUES FOR THE TREATMENT OF CANCER PROSTATE RESISTANT TO CASTRATION |
US9058753B2 (en) | 2012-03-23 | 2015-06-16 | Documotion Research, Inc. | Paper, labels made therefrom and methods of making paper and labels |
WO2017134265A1 (en) | 2016-02-05 | 2017-08-10 | Institut Pasteur | Use of inhibitors of adam12 as adjuvants in tumor therapies |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1579495A (ko) * | 1968-01-22 | 1969-08-29 | ||
IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
DE2008332C3 (de) * | 1970-02-23 | 1980-05-22 | Istituto Biologico Chemioterapico Abc S.P.A., Turin (Italien) | 2-Methyl-S-methoxy-3-indolylacetohydroxamsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4092430A (en) * | 1970-09-09 | 1978-05-30 | Ciba-Geigy Corporation | Antiphlogistic phenylacetohydroxamic acid compositions |
US4173577A (en) * | 1970-09-09 | 1979-11-06 | Ciba-Geigy Corporation | Phenylacetohydroxamic acids |
US4029815A (en) * | 1975-04-30 | 1977-06-14 | Schering Corporation | Anti-diarrheal anthranilic acids |
PT72878B (en) * | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
EP0103895A3 (en) * | 1982-09-22 | 1985-07-03 | Meiji Seika Kabushiki Kaisha | Novel hydroxylamine derivatives, production and use thereof |
NO165341C (no) * | 1985-03-16 | 1991-01-30 | Wellcome Found | Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksamsyrearylderivater. |
US4792560A (en) * | 1985-04-03 | 1988-12-20 | Rorer Pharmaceutical Corporation | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
-
1988
- 1988-05-19 US US07/196,584 patent/US4943587A/en not_active Expired - Fee Related
-
1989
- 1989-04-27 AU AU33836/89A patent/AU623900B2/en not_active Ceased
- 1989-05-12 ZA ZA893578A patent/ZA893578B/xx unknown
- 1989-05-15 FI FI892322A patent/FI892322A/fi not_active IP Right Cessation
- 1989-05-16 NO NO89891951A patent/NO891951L/no unknown
- 1989-05-17 NZ NZ229174A patent/NZ229174A/xx unknown
- 1989-05-18 JP JP1123016A patent/JPH0236163A/ja active Pending
- 1989-05-18 PT PT90602A patent/PT90602B/pt not_active IP Right Cessation
- 1989-05-18 EP EP19890108976 patent/EP0342682A3/en not_active Ceased
- 1989-05-18 DK DK242389A patent/DK242389A/da unknown
- 1989-05-19 KR KR1019890006709A patent/KR890017233A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK242389D0 (da) | 1989-05-18 |
NO891951D0 (no) | 1989-05-16 |
AU623900B2 (en) | 1992-05-28 |
NO891951L (no) | 1989-11-20 |
FI892322A0 (fi) | 1989-05-15 |
KR890017233A (ko) | 1989-12-15 |
PT90602A (pt) | 1989-11-30 |
DK242389A (da) | 1989-11-20 |
PT90602B (pt) | 1994-09-30 |
FI892322A (fi) | 1989-11-20 |
NZ229174A (en) | 1991-08-27 |
EP0342682A2 (en) | 1989-11-23 |
JPH0236163A (ja) | 1990-02-06 |
AU3383689A (en) | 1989-11-23 |
EP0342682A3 (en) | 1991-12-11 |
US4943587A (en) | 1990-07-24 |
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