ZA889392B - Epipodophyllotoxin glucoside 4"-acyl derivatives - Google Patents

Epipodophyllotoxin glucoside 4"-acyl derivatives

Info

Publication number
ZA889392B
ZA889392B ZA889392A ZA889392A ZA889392B ZA 889392 B ZA889392 B ZA 889392B ZA 889392 A ZA889392 A ZA 889392A ZA 889392 A ZA889392 A ZA 889392A ZA 889392 B ZA889392 B ZA 889392B
Authority
ZA
South Africa
Prior art keywords
acyl derivatives
epipodophyllotoxin glucoside
epipodophyllotoxin
glucoside
acyl
Prior art date
Application number
ZA889392A
Other languages
English (en)
Inventor
Mark G Saulnier
G Saulnier Mark
Dolatrai M Vyas
M Vyas Dolatrai
David R Langley
R Langley David
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA889392B publication Critical patent/ZA889392B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA889392A 1987-12-18 1988-12-15 Epipodophyllotoxin glucoside 4"-acyl derivatives ZA889392B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13512987A 1987-12-18 1987-12-18

Publications (1)

Publication Number Publication Date
ZA889392B true ZA889392B (en) 1989-09-27

Family

ID=22466687

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA886810A ZA886810B (en) 1987-12-18 1988-09-13 Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA889392A ZA889392B (en) 1987-12-18 1988-12-15 Epipodophyllotoxin glucoside 4"-acyl derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA886810A ZA886810B (en) 1987-12-18 1988-09-13 Epipodophyllotoxin glucoside 4'-acyl derivatives

Country Status (16)

Country Link
EP (1) EP0320988A3 (xx)
JP (1) JPH01279896A (xx)
KR (1) KR910008799B1 (xx)
CN (1) CN1033631A (xx)
AU (1) AU616717B2 (xx)
CA (1) CA1312074C (xx)
DD (2) DD283401A5 (xx)
DK (1) DK702688A (xx)
FI (1) FI885785A (xx)
HU (1) HU202548B (xx)
MY (1) MY104067A (xx)
NO (1) NO167668C (xx)
NZ (1) NZ227286A (xx)
PT (1) PT89253B (xx)
YU (2) YU179088A (xx)
ZA (2) ZA886810B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
FR2655047A1 (fr) * 1989-11-24 1991-05-31 Pf Medicament Derives d'etoposide, leur preparation et leur application comme intermediaires de synthese.
EP0540263A1 (en) * 1991-10-23 1993-05-05 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
CA2468479C (en) 2001-12-03 2010-04-27 Universitaetsklinikum Charite Der Humboldt-Universitaet Zu Berlin Technologietransferstelle Podophyllotoxins as antiproliferative agents
GB0421296D0 (en) * 2004-09-24 2004-10-27 Angiogene Pharm Ltd Bioreductively-activated prodrugs
CN104622809B (zh) * 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE546388A (xx) *
NL6613143A (xx) * 1965-09-21 1967-03-22
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Also Published As

Publication number Publication date
CN1033631A (zh) 1989-07-05
EP0320988A3 (en) 1990-08-22
JPH01279896A (ja) 1989-11-10
AU2706288A (en) 1989-06-29
NO885565D0 (no) 1988-12-15
DK702688D0 (da) 1988-12-16
AU616717B2 (en) 1991-11-07
DK702688A (da) 1989-06-19
DD283401A5 (de) 1990-10-10
ZA886810B (en) 1989-08-30
FI885785A (fi) 1989-06-19
FI885785A0 (fi) 1988-12-14
DD296082A5 (de) 1991-11-21
NO167668C (no) 1991-11-27
NO167668B (no) 1991-08-19
KR910008799B1 (ko) 1991-10-21
YU179088A (en) 1990-02-28
MY104067A (en) 1993-11-30
CA1312074C (en) 1992-12-29
KR890009965A (ko) 1989-08-05
YU228388A (sh) 1993-10-20
EP0320988A2 (en) 1989-06-21
NZ227286A (en) 1991-08-27
HU202548B (en) 1991-03-28
NO885565L (no) 1989-06-19
HUT48641A (en) 1989-06-28
PT89253B (pt) 1993-07-30
PT89253A (pt) 1989-12-29

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