ZA884918B - 7-(1h-pyrrol-3-)-substituted-3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids,their corresponding gamma-lactones and salts,processes for their preparation,their use as medicaments,pharmaceutical products and intermediates - Google Patents
7-(1h-pyrrol-3-)-substituted-3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids,their corresponding gamma-lactones and salts,processes for their preparation,their use as medicaments,pharmaceutical products and intermediatesInfo
- Publication number
- ZA884918B ZA884918B ZA884918A ZA884918A ZA884918B ZA 884918 B ZA884918 B ZA 884918B ZA 884918 A ZA884918 A ZA 884918A ZA 884918 A ZA884918 A ZA 884918A ZA 884918 B ZA884918 B ZA 884918B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrrol
- substituted
- acids
- dihydroxyhept
- lactones
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 2
- 150000007513 acids Chemical class 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 125000000457 gamma-lactone group Chemical group 0.000 title 1
- 239000012450 pharmaceutical intermediate Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- -1 7-[1H-Pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids Chemical class 0.000 abstract 2
- 125000000422 delta-lactone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873722806 DE3722806A1 (de) | 1987-07-10 | 1987-07-10 | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA884918B true ZA884918B (en) | 1989-01-18 |
Family
ID=6331291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA884918A ZA884918B (en) | 1987-07-10 | 1988-07-08 | 7-(1h-pyrrol-3-)-substituted-3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids,their corresponding gamma-lactones and salts,processes for their preparation,their use as medicaments,pharmaceutical products and intermediates |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5055484A (hu) |
| EP (1) | EP0300249B1 (hu) |
| JP (1) | JPS6434959A (hu) |
| KR (1) | KR890002135A (hu) |
| AT (1) | ATE85324T1 (hu) |
| AU (1) | AU1888088A (hu) |
| DE (2) | DE3722806A1 (hu) |
| DK (1) | DK384288A (hu) |
| ES (1) | ES2043736T3 (hu) |
| FI (1) | FI883247A (hu) |
| GR (1) | GR3007611T3 (hu) |
| HU (1) | HU208672B (hu) |
| IE (1) | IE63205B1 (hu) |
| IL (1) | IL87036A0 (hu) |
| NO (1) | NO883072L (hu) |
| NZ (1) | NZ225342A (hu) |
| PH (1) | PH26375A (hu) |
| PT (1) | PT87927B (hu) |
| ZA (1) | ZA884918B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3826814A1 (de) * | 1988-08-06 | 1990-02-08 | Hoechst Ag | Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| IT1237793B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5128366A (en) * | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
| DE4243279A1 (de) * | 1992-12-21 | 1994-06-23 | Bayer Ag | Substituierte Triole |
| US7250444B2 (en) * | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928380A (en) * | 1973-03-29 | 1975-12-23 | Sterling Drug Inc | 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles) |
| US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
| US4851427A (en) * | 1985-10-25 | 1989-07-25 | Sandoz Pharm. Corp. | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use |
| HUT48208A (en) * | 1985-10-25 | 1989-05-29 | Sandoz Ag | Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compounds |
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
-
1987
- 1987-07-10 DE DE19873722806 patent/DE3722806A1/de not_active Withdrawn
-
1988
- 1988-07-01 DE DE8888110533T patent/DE3878067D1/de not_active Expired - Fee Related
- 1988-07-01 ES ES88110533T patent/ES2043736T3/es not_active Expired - Lifetime
- 1988-07-01 EP EP88110533A patent/EP0300249B1/de not_active Expired - Lifetime
- 1988-07-01 AT AT88110533T patent/ATE85324T1/de not_active IP Right Cessation
- 1988-07-07 FI FI883247A patent/FI883247A/fi not_active Application Discontinuation
- 1988-07-07 PT PT87927A patent/PT87927B/pt not_active IP Right Cessation
- 1988-07-08 JP JP63169159A patent/JPS6434959A/ja active Pending
- 1988-07-08 IL IL87036A patent/IL87036A0/xx unknown
- 1988-07-08 HU HU883600A patent/HU208672B/hu not_active IP Right Cessation
- 1988-07-08 NZ NZ225342A patent/NZ225342A/en unknown
- 1988-07-08 DK DK384288A patent/DK384288A/da not_active Application Discontinuation
- 1988-07-08 IE IE209788A patent/IE63205B1/en not_active IP Right Cessation
- 1988-07-08 US US07/216,423 patent/US5055484A/en not_active Expired - Fee Related
- 1988-07-08 NO NO88883072A patent/NO883072L/no unknown
- 1988-07-08 ZA ZA884918A patent/ZA884918B/xx unknown
- 1988-07-08 AU AU18880/88A patent/AU1888088A/en not_active Abandoned
- 1988-07-08 PH PH37199A patent/PH26375A/en unknown
- 1988-07-09 KR KR1019880008546A patent/KR890002135A/ko not_active Application Discontinuation
-
1993
- 1993-04-09 GR GR930400426T patent/GR3007611T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2043736T3 (es) | 1994-01-01 |
| IE882097L (en) | 1989-01-10 |
| DE3722806A1 (de) | 1989-01-19 |
| HU208672B (en) | 1993-12-28 |
| IL87036A0 (en) | 1988-12-30 |
| US5055484A (en) | 1991-10-08 |
| NZ225342A (en) | 1991-03-26 |
| HUT48580A (en) | 1989-06-28 |
| EP0300249B1 (de) | 1993-02-03 |
| AU1888088A (en) | 1989-01-12 |
| NO883072D0 (no) | 1988-07-08 |
| EP0300249A1 (de) | 1989-01-25 |
| DK384288D0 (da) | 1988-07-08 |
| KR890002135A (ko) | 1989-04-08 |
| PT87927B (pt) | 1995-03-01 |
| PT87927A (pt) | 1989-06-30 |
| FI883247A0 (fi) | 1988-07-07 |
| NO883072L (no) | 1989-01-11 |
| PH26375A (en) | 1992-06-01 |
| GR3007611T3 (hu) | 1993-08-31 |
| DE3878067D1 (de) | 1993-03-18 |
| ATE85324T1 (de) | 1993-02-15 |
| DK384288A (da) | 1989-01-11 |
| JPS6434959A (en) | 1989-02-06 |
| FI883247A (fi) | 1989-01-11 |
| IE63205B1 (en) | 1995-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA897233B (en) | 7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acid,a process for the preparation thereof,the use thereof as pharmaceuticals,and intermediates | |
| ZA884919B (en) | 3-demethylmevalonic acid derivatives,a process for their preparation,pharmaceutical products based on these compounds,their use and intermediates | |
| FI941245A (fi) | Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi | |
| AU629977B2 (en) | 4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors | |
| JPS6438086A (en) | Mevalonic acid derivative and manufacture | |
| ZA884918B (en) | 7-(1h-pyrrol-3-)-substituted-3,5-dihydroxyhept-6-enoic acids,7-(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyheptanoic acids,their corresponding gamma-lactones and salts,processes for their preparation,their use as medicaments,pharmaceutical products and intermediates | |
| ZA895959B (en) | New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof,a process for the preparation thereof,the use thereof as medicinal agents,pharmaceutical products and intermediates | |
| EP0244833A3 (en) | 4(r)-substituted 6(s)-phenoxymethyl-, 6(s)-beta-phenylethyl- and 6(s)-beta-styryl-tetrahydropyran-2-ones, a highly stereoselective process for their preparation, pharmaceutical preparation based on these compounds and their use | |
| GR3001809T3 (en) | Benzylaminoaryldihydropyridine lactones, process for their preparation and their use in medicaments |