ZA883762B - Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives - Google Patents

Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Info

Publication number
ZA883762B
ZA883762B ZA883762A ZA883762A ZA883762B ZA 883762 B ZA883762 B ZA 883762B ZA 883762 A ZA883762 A ZA 883762A ZA 883762 A ZA883762 A ZA 883762A ZA 883762 B ZA883762 B ZA 883762B
Authority
ZA
South Africa
Prior art keywords
novel
glucoside derivatives
dinitrogen
substituted
epipodophyllotoxin glucoside
Prior art date
Application number
ZA883762A
Other languages
English (en)
Inventor
Dolatrai Mohanla Vyas
Mohanla Vyas Dolatrai
Mark George Saulnier
George Saulnier Mark
John F Kadow
F Kadow John
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA883762B publication Critical patent/ZA883762B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA883762A 1987-07-01 1988-05-26 Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives ZA883762B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/068,376 US4874851A (en) 1987-07-01 1987-07-01 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Publications (1)

Publication Number Publication Date
ZA883762B true ZA883762B (en) 1989-03-29

Family

ID=22082167

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883762A ZA883762B (en) 1987-07-01 1988-05-26 Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Country Status (13)

Country Link
US (1) US4874851A (no)
EP (1) EP0297594A3 (no)
JP (1) JPS6426592A (no)
KR (1) KR900006234B1 (no)
AU (1) AU618536B2 (no)
CA (1) CA1306250C (no)
DK (1) DK360888A (no)
FI (1) FI87357C (no)
IL (1) IL86888A0 (no)
NO (1) NO167807C (no)
NZ (1) NZ225089A (no)
PT (1) PT87893A (no)
ZA (1) ZA883762B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
KR100377556B1 (ko) * 1999-01-27 2003-03-26 주식회사 엘지생명과학 세픽심 제조에 유용한 중간체의 제조방법
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (no) * 1965-09-21 1967-03-22
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides

Also Published As

Publication number Publication date
FI87357B (fi) 1992-09-15
JPS6426592A (en) 1989-01-27
FI883088A (fi) 1989-01-02
PT87893A (pt) 1989-06-30
KR900006234B1 (ko) 1990-08-27
IL86888A0 (en) 1988-11-30
AU1844688A (en) 1989-01-19
NO167807C (no) 1991-12-11
DK360888A (da) 1989-01-02
DK360888D0 (da) 1988-06-30
FI87357C (fi) 1992-12-28
KR890002215A (ko) 1989-04-10
AU618536B2 (en) 1992-01-02
EP0297594A3 (en) 1990-07-25
EP0297594A2 (en) 1989-01-04
FI883088A0 (fi) 1988-06-28
CA1306250C (en) 1992-08-11
NO882849L (no) 1989-01-02
NO882849D0 (no) 1988-06-28
US4874851A (en) 1989-10-17
NO167807B (no) 1991-09-02
NZ225089A (en) 1991-06-25

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