ZA882016B - Stable solvent adducts of z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene - Google Patents

Stable solvent adducts of z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene

Info

Publication number
ZA882016B
ZA882016B ZA882016A ZA882016A ZA882016B ZA 882016 B ZA882016 B ZA 882016B ZA 882016 A ZA882016 A ZA 882016A ZA 882016 A ZA882016 A ZA 882016A ZA 882016 B ZA882016 B ZA 882016B
Authority
ZA
South Africa
Prior art keywords
dimethylaminoethoxyphenyl
ene
hydroxyphenyl
beta
phenyl
Prior art date
Application number
ZA882016A
Other languages
English (en)
Inventor
Ingo Dr Margrafe
Margrafe Dr Ingo
Helmut Dr Schickaneder
Schickaneder Dr Helmut
Peter W Prof Dr Jungblut
W Jungblut Prof Dr Peter
Kurt Henning Dr Ahrens
Henning Ahrens Dr Kurt
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of ZA882016B publication Critical patent/ZA882016B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA882016A 1987-04-21 1988-03-22 Stable solvent adducts of z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene ZA882016B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87105803A EP0287690B1 (fr) 1987-04-21 1987-04-21 Adducts stables de solvant avec Z-1-(p-bêta-diméthylamino-éthoxyphényl)-1-(p-hydroxyphényl)-2-phénylbut-1-ène

Publications (1)

Publication Number Publication Date
ZA882016B true ZA882016B (en) 1988-12-28

Family

ID=8196934

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA882016A ZA882016B (en) 1987-04-21 1988-03-22 Stable solvent adducts of z-1-(p-beta-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene

Country Status (18)

Country Link
US (1) US4973755A (fr)
EP (1) EP0287690B1 (fr)
JP (1) JP2596446B2 (fr)
KR (1) KR940010274B1 (fr)
AR (1) AR243494A1 (fr)
AT (1) ATE80152T1 (fr)
AU (1) AU607198B2 (fr)
CA (1) CA1305972C (fr)
DE (1) DE3781546D1 (fr)
DK (1) DK171748B1 (fr)
ES (1) ES2044860T3 (fr)
GR (1) GR3005582T3 (fr)
HU (1) HU204501B (fr)
IE (1) IE62488B1 (fr)
IL (1) IL85804A (fr)
NZ (1) NZ224296A (fr)
PT (1) PT87268B (fr)
ZA (1) ZA882016B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5847007A (en) * 1993-05-13 1998-12-08 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1995011879A1 (fr) * 1993-10-25 1995-05-04 Taiho Pharmaceutical Co., Ltd. Procede de production de sel d'addition d'acide d'isomere z de compose de triphenylethylene
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
AU6277396A (en) 1995-06-07 1996-12-30 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
AU725286B2 (en) 1996-01-20 2000-10-12 Bradford University Tamoxifen and analogues thereof
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
US6083990A (en) 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
WO1998046588A2 (fr) 1997-04-11 1998-10-22 Neorx Corporation Composes et therapies destines a la prevention d'affections vasculaires ou non vasculaires
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
EP1043986B1 (fr) * 1997-12-23 2003-04-16 Hexal Ag Melange et composition pharmaceutique comprenant du z-4- hydroxytamoxifene et de la cyclodextrine
SI1572178T1 (sl) * 2002-12-18 2006-10-31 Besins Int Lab Zdravljenje mastalgije s 4-hidroksi-tamoksifenom
AU2003296757A1 (en) * 2002-12-18 2004-07-09 Laboratoires Besins International Reduction of breast density with 4-hydroxy tamoxifen
MXPA05010597A (es) * 2003-04-01 2006-03-09 Lab Besins Internat Prevencion y tratamiento de cancer de mama con tamoxifen 4-hidroxi.
NZ544031A (en) * 2003-06-09 2008-08-29 Univ Northwestern Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
KR20060039867A (ko) * 2003-06-20 2006-05-09 바이럴 게노믹스, 인크. Ｈｉｖ 치료를 위한 조성물 및 방법
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
EP1579856A1 (fr) * 2004-03-22 2005-09-28 Laboratoires Besins International 4-Hydroxytamoxifène destiné au traitement des maladies bénignes des seins
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
AU2005227072B2 (en) * 2004-03-22 2010-08-19 Besins Healthcare Luxembourg Sarl Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (fr) * 1962-09-13
GB1099093A (en) * 1965-09-03 1968-01-17 Ici Ltd Alkene derivatives
GB1560274A (en) * 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
DE2860900D1 (en) * 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE3239610A1 (de) * 1982-10-26 1984-04-26 Klinge Pharma GmbH, 8000 München Neue 1,1,2-triphenyl-but-l-en-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
AU1379888A (en) 1988-10-20
EP0287690A1 (fr) 1988-10-26
AR243494A1 (es) 1993-08-31
AU607198B2 (en) 1991-02-28
KR940010274B1 (ko) 1994-10-22
PT87268A (pt) 1988-05-01
JP2596446B2 (ja) 1997-04-02
NZ224296A (en) 1990-02-26
HUT50318A (en) 1990-01-29
JPS6445347A (en) 1989-02-17
IL85804A (en) 1991-07-18
IE62488B1 (en) 1995-02-08
DK189888D0 (da) 1988-04-07
IL85804A0 (en) 1988-09-30
DE3781546D1 (de) 1992-10-08
DK189888A (da) 1988-10-22
KR880012528A (ko) 1988-11-28
PT87268B (pt) 1992-08-31
GR3005582T3 (fr) 1993-06-07
CA1305972C (fr) 1992-08-04
DK171748B1 (da) 1997-05-05
ES2044860T3 (es) 1994-01-16
HU204501B (en) 1992-01-28
ATE80152T1 (de) 1992-09-15
EP0287690B1 (fr) 1992-09-02
US4973755A (en) 1990-11-27

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