ZA881835B - Avermectin derivatives - Google Patents

Avermectin derivatives

Info

Publication number
ZA881835B
ZA881835B ZA881835A ZA881835A ZA881835B ZA 881835 B ZA881835 B ZA 881835B ZA 881835 A ZA881835 A ZA 881835A ZA 881835 A ZA881835 A ZA 881835A ZA 881835 B ZA881835 B ZA 881835B
Authority
ZA
South Africa
Prior art keywords
avermectin derivatives
avermectin
derivatives
Prior art date
Application number
ZA881835A
Other languages
English (en)
Inventor
G. Christensen Burton
Mrozik Helmut
H. Fisher Michael
Original Assignee
Merck & Co.,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co.,Inc. filed Critical Merck & Co.,Inc.
Publication of ZA881835B publication Critical patent/ZA881835B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA881835A 1987-03-16 1988-03-15 Avermectin derivatives ZA881835B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/026,409 US4806527A (en) 1987-03-16 1987-03-16 Avermectin derivatives

Publications (1)

Publication Number Publication Date
ZA881835B true ZA881835B (en) 1988-09-08

Family

ID=21831665

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA881835A ZA881835B (en) 1987-03-16 1988-03-15 Avermectin derivatives

Country Status (6)

Country Link
US (1) US4806527A (de)
EP (1) EP0284255A1 (de)
JP (1) JP2669635B2 (de)
AU (1) AU599764B2 (de)
NZ (1) NZ223771A (de)
ZA (1) ZA881835B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1288425C (en) * 1986-03-12 1991-09-03 Michael V.J. Ramsay Macrolide compounds
NL8700581A (nl) * 1986-03-12 1987-10-01 Glaxo Group Ltd Antibioticum, preparaat dat dat bevat, werkwijze voor de bereiding daarvan, werkwijze voor het bestrijden van plagen en nieuwe streptomyces-mutant.
CA1287048C (en) * 1986-03-12 1991-07-30 Paul F. Lambeth Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
GB8721373D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721371D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
US5120646A (en) * 1988-10-18 1992-06-09 Chen Shieh Shung T Process for the preparation of anthelmintive bioconversion products
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
GB8905605D0 (en) * 1989-03-11 1989-04-26 Beecham Group Plc Novel compounds
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
US4967186A (en) * 1989-08-18 1990-10-30 Ariold Ludmirsky Method and apparatus for fatigue detection
DK0423445T3 (da) * 1989-09-11 1995-12-11 American Cyanamid Co 12-Alkyl-23-imino- og 13-halogen-23-imino-derivater af LL-F28249-forbindelser og deres anvendelse som endo- og ektoparasiticide, insekticide, akaricide og nematodicide midler
US5030650A (en) * 1989-09-11 1991-07-09 American Cyanamid Company 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
EP0443733B1 (de) * 1990-02-08 1993-07-21 Merck & Co. Inc. Verfahren zur Bekämpfung von Flöhen
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
CA2173494C (en) * 1993-10-05 1999-04-13 Thomas C. Crawford Process and antiparasitic intermediates for doramectin
BRPI0922709B8 (pt) 2008-12-04 2017-03-14 Merial Ltd derivados diméricos de avermectina e milbemicina
MX2012006921A (es) 2009-12-17 2012-07-10 Merial Ltd Composiciones que comprenden compuestos de lactona macrociclica y espirodioxepinoindoles.
CA2857958C (en) 2011-12-02 2020-08-25 Merial Limited Long-acting injectable moxidectin formulations and moxidectin crystal forms

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4203979A (en) * 1979-01-16 1980-05-20 Gaf Corporation Insecticidal 1-sec. and tert.-alkyl-2-disubstituted-phosphoryl hydrazines
US4328335A (en) * 1979-08-13 1982-05-04 Merck & Co., Inc. Process for the interconversion of C-076 compounds
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
DK614084A (da) * 1983-12-30 1985-07-01 Ciba Geigy Ag Milbemycim-derivater samt deres fremstilling og anvendelse
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
IT1182857B (it) * 1984-09-14 1987-10-05 Glaxo Group Ltd Composti antibiotici, composizioni antiparassitarie che li contengono e procedimento per prepararli ed applicarli
JPS61103884A (ja) * 1984-10-26 1986-05-22 Sankyo Co Ltd １３−置換−５−ケトミルベマイシン類およびその製造法
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
ATE119905T1 (de) * 1985-09-13 1995-04-15 American Cyanamid Co Makrolide antibiotika und verfahren zu deren herstellung.
ES2061487T3 (es) * 1986-03-12 1994-12-16 American Cyanamid Co Compuestos macrolidos.
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
ES2058082T3 (es) * 1986-09-12 1994-11-01 American Cyanamid Co Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249.
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer

Also Published As

Publication number Publication date
AU599764B2 (en) 1990-07-26
NZ223771A (en) 1991-02-26
JP2669635B2 (ja) 1997-10-29
EP0284255A1 (de) 1988-09-28
AU1313288A (en) 1988-09-15
JPS63238083A (ja) 1988-10-04
US4806527A (en) 1989-02-21

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