AU599764B2 - Avermectin derivatives - Google Patents

Avermectin derivatives Download PDF

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Publication number
AU599764B2
AU599764B2 AU13132/88A AU1313288A AU599764B2 AU 599764 B2 AU599764 B2 AU 599764B2 AU 13132/88 A AU13132/88 A AU 13132/88A AU 1313288 A AU1313288 A AU 1313288A AU 599764 B2 AU599764 B2 AU 599764B2
Authority
AU
Australia
Prior art keywords
hydroxy
compound
reaction
group
aglycone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU13132/88A
Other languages
English (en)
Other versions
AU1313288A (en
Inventor
Burton G. Christensen
Michael H. Fisher
Helmut Mrozik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1313288A publication Critical patent/AU1313288A/en
Application granted granted Critical
Publication of AU599764B2 publication Critical patent/AU599764B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU13132/88A 1987-03-16 1988-03-15 Avermectin derivatives Ceased AU599764B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US026409 1987-03-16
US07/026,409 US4806527A (en) 1987-03-16 1987-03-16 Avermectin derivatives

Publications (2)

Publication Number Publication Date
AU1313288A AU1313288A (en) 1988-09-15
AU599764B2 true AU599764B2 (en) 1990-07-26

Family

ID=21831665

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13132/88A Ceased AU599764B2 (en) 1987-03-16 1988-03-15 Avermectin derivatives

Country Status (6)

Country Link
US (1) US4806527A (de)
EP (1) EP0284255A1 (de)
JP (1) JP2669635B2 (de)
AU (1) AU599764B2 (de)
NZ (1) NZ223771A (de)
ZA (1) ZA881835B (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614123B2 (en) * 1988-05-02 1991-08-22 Merck & Co., Inc. Fluoroavermectin and fluoromilbemycin derivatives with antiparasitic and pesticidal properties
AU620102B2 (en) * 1988-06-10 1992-02-13 American Cyanamid Company Process for the preparation of macrolide compounds
AU621063B2 (en) * 1987-09-11 1992-03-05 American Cyanamid Company Process for the preparation of macrolide compounds
AU630992B2 (en) * 1989-07-31 1992-11-12 Merck & Co., Inc. Avermectin derivatives
AU631454B2 (en) * 1989-09-11 1992-11-26 Wyeth Holdings Corporation 13-alkyl-23-imino and 13-halo-23-imino derivatives of ll-f28249 compounds and their use as endo- and ecto-parasiticidal, insecticidal, acaricidal and nematocidal agents

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1288425C (en) * 1986-03-12 1991-09-03 Michael V.J. Ramsay Macrolide compounds
NL8700581A (nl) * 1986-03-12 1987-10-01 Glaxo Group Ltd Antibioticum, preparaat dat dat bevat, werkwijze voor de bereiding daarvan, werkwijze voor het bestrijden van plagen en nieuwe streptomyces-mutant.
CA1287048C (en) * 1986-03-12 1991-07-30 Paul F. Lambeth Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
GB8721371D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
US5120646A (en) * 1988-10-18 1992-06-09 Chen Shieh Shung T Process for the preparation of anthelmintive bioconversion products
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
GB8905605D0 (en) * 1989-03-11 1989-04-26 Beecham Group Plc Novel compounds
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
US4967186A (en) * 1989-08-18 1990-10-30 Ariold Ludmirsky Method and apparatus for fatigue detection
US5030650A (en) * 1989-09-11 1991-07-09 American Cyanamid Company 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
EP0443733B1 (de) * 1990-02-08 1993-07-21 Merck & Co. Inc. Verfahren zur Bekämpfung von Flöhen
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
CA2173494C (en) * 1993-10-05 1999-04-13 Thomas C. Crawford Process and antiparasitic intermediates for doramectin
BRPI0922709B8 (pt) 2008-12-04 2017-03-14 Merial Ltd derivados diméricos de avermectina e milbemicina
MX2012006921A (es) 2009-12-17 2012-07-10 Merial Ltd Composiciones que comprenden compuestos de lactona macrociclica y espirodioxepinoindoles.
CA2857958C (en) 2011-12-02 2020-08-25 Merial Limited Long-acting injectable moxidectin formulations and moxidectin crystal forms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5676786A (en) * 1985-04-30 1986-11-06 American Cyanamid Company Chemical derivatives of antibiotics S541
AU7827687A (en) * 1986-09-12 1988-03-17 Wyeth Holdings Corporation Macrolide derivatives
AU572402B2 (en) * 1985-07-27 1988-05-05 Pfizer Corp. 25-avermectin derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4203979A (en) * 1979-01-16 1980-05-20 Gaf Corporation Insecticidal 1-sec. and tert.-alkyl-2-disubstituted-phosphoryl hydrazines
US4328335A (en) * 1979-08-13 1982-05-04 Merck & Co., Inc. Process for the interconversion of C-076 compounds
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
DK614084A (da) * 1983-12-30 1985-07-01 Ciba Geigy Ag Milbemycim-derivater samt deres fremstilling og anvendelse
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
IT1182857B (it) * 1984-09-14 1987-10-05 Glaxo Group Ltd Composti antibiotici, composizioni antiparassitarie che li contengono e procedimento per prepararli ed applicarli
JPS61103884A (ja) * 1984-10-26 1986-05-22 Sankyo Co Ltd １３−置換−５−ケトミルベマイシン類およびその製造法
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
ATE119905T1 (de) * 1985-09-13 1995-04-15 American Cyanamid Co Makrolide antibiotika und verfahren zu deren herstellung.
ES2061487T3 (es) * 1986-03-12 1994-12-16 American Cyanamid Co Compuestos macrolidos.
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
ES2058082T3 (es) * 1986-09-12 1994-11-01 American Cyanamid Co Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249.
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5676786A (en) * 1985-04-30 1986-11-06 American Cyanamid Company Chemical derivatives of antibiotics S541
AU572402B2 (en) * 1985-07-27 1988-05-05 Pfizer Corp. 25-avermectin derivatives
AU7827687A (en) * 1986-09-12 1988-03-17 Wyeth Holdings Corporation Macrolide derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621063B2 (en) * 1987-09-11 1992-03-05 American Cyanamid Company Process for the preparation of macrolide compounds
AU614123B2 (en) * 1988-05-02 1991-08-22 Merck & Co., Inc. Fluoroavermectin and fluoromilbemycin derivatives with antiparasitic and pesticidal properties
AU620102B2 (en) * 1988-06-10 1992-02-13 American Cyanamid Company Process for the preparation of macrolide compounds
AU630992B2 (en) * 1989-07-31 1992-11-12 Merck & Co., Inc. Avermectin derivatives
AU631454B2 (en) * 1989-09-11 1992-11-26 Wyeth Holdings Corporation 13-alkyl-23-imino and 13-halo-23-imino derivatives of ll-f28249 compounds and their use as endo- and ecto-parasiticidal, insecticidal, acaricidal and nematocidal agents

Also Published As

Publication number Publication date
NZ223771A (en) 1991-02-26
JP2669635B2 (ja) 1997-10-29
EP0284255A1 (de) 1988-09-28
AU1313288A (en) 1988-09-15
JPS63238083A (ja) 1988-10-04
ZA881835B (en) 1988-09-08
US4806527A (en) 1989-02-21

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