ZA881030B - 19-nor steroids substituted in position 7,their preparation,application as medicaments,compositions containing them - Google Patents

19-nor steroids substituted in position 7,their preparation,application as medicaments,compositions containing them

Info

Publication number
ZA881030B
ZA881030B ZA881030A ZA881030A ZA881030B ZA 881030 B ZA881030 B ZA 881030B ZA 881030 A ZA881030 A ZA 881030A ZA 881030 A ZA881030 A ZA 881030A ZA 881030 B ZA881030 B ZA 881030B
Authority
ZA
South Africa
Prior art keywords
group
carbon atoms
hydrogen
optionally substituted
image
Prior art date
Application number
ZA881030A
Other languages
English (en)
Inventor
Francois Nique
Nique Francois
Lucien Nedelec
Nedelec Lucien
Marie-Madeleine Bouton
Bouton Marie-Madeleine
Daniel Philibert
Philibert Daniel
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA881030B publication Critical patent/ZA881030B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
ZA881030A 1987-02-18 1988-02-15 19-nor steroids substituted in position 7,their preparation,application as medicaments,compositions containing them ZA881030B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8702072A FR2610933B1 (fr) 1987-02-18 1987-02-18 Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ZA881030B true ZA881030B (en) 1989-04-26

Family

ID=9348042

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA881030A ZA881030B (en) 1987-02-18 1988-02-15 19-nor steroids substituted in position 7,their preparation,application as medicaments,compositions containing them

Country Status (15)

Country Link
US (1) US4874754A (de)
EP (1) EP0280618B1 (de)
JP (1) JP2717792B2 (de)
KR (1) KR960007868B1 (de)
AT (1) ATE81133T1 (de)
AU (1) AU610560B2 (de)
CA (1) CA1313653C (de)
DE (1) DE3874909T2 (de)
ES (1) ES2043862T3 (de)
FI (1) FI92589C (de)
FR (1) FR2610933B1 (de)
GR (1) GR3006139T3 (de)
MX (1) MX174129B (de)
PT (1) PT86783B (de)
ZA (1) ZA881030B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
HU208150B (en) * 1988-10-31 1993-08-30 Endorecherche Inc Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
US5686465A (en) * 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5204337A (en) * 1988-10-31 1993-04-20 Endorecherche Inc. Estrogen nucleus derivatives for use in inhibition of sex steroid activity
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
ZA924811B (en) * 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
WO1995018821A2 (en) * 1994-01-06 1995-07-13 Sri International Novel antiandrogenic agents and related pharmaceutical compositions and methods of use
US6355630B1 (en) 1997-10-23 2002-03-12 American Home Products Corporation Estra-1,3,5(10)-triene-7α-thioethers
EP1025116A1 (de) * 1997-10-23 2000-08-09 American Home Products Corporation Oestra-1,3,5(10)-trien-7alpha-thioether
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
ATE404577T1 (de) * 2002-03-22 2008-08-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von eplerenon
PL356465A1 (en) * 2002-10-04 2004-04-05 ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
WO2012058463A2 (en) 2010-10-27 2012-05-03 Dignity Health Trimegestone (tmg) for treatment of preterm birth

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739974A (en) 1953-04-06 1956-03-27 Searle & Co Process of preparing delta4,6-3-ketosteroids
US3099664A (en) 1959-01-12 1963-07-30 Syntex Corp 7-cyano androstane compounds
US3673225A (en) * 1970-01-16 1972-06-27 Organon New 7-alkyl-steroids
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3427795A1 (de) * 1984-07-25 1986-02-06 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 17(alpha)-halogenvinyl-estran-derivate, ihre herstellung und verwendung in der medizin

Also Published As

Publication number Publication date
CA1313653C (fr) 1993-02-16
JP2717792B2 (ja) 1998-02-25
ES2043862T3 (es) 1994-01-01
FI92589B (fi) 1994-08-31
DE3874909T2 (de) 1993-05-13
MX174129B (es) 1994-04-22
KR960007868B1 (ko) 1996-06-13
AU610560B2 (en) 1991-05-23
EP0280618A1 (de) 1988-08-31
MX10471A (es) 1993-09-01
DE3874909D1 (de) 1992-11-05
KR880009987A (ko) 1988-10-06
EP0280618B1 (de) 1992-09-30
FR2610933B1 (fr) 1989-06-09
FR2610933A1 (fr) 1988-08-19
AU1178588A (en) 1988-08-25
US4874754A (en) 1989-10-17
FI880742A0 (fi) 1988-02-17
FI880742A (fi) 1988-08-19
PT86783B (pt) 1992-05-29
JPS63222198A (ja) 1988-09-16
GR3006139T3 (de) 1993-06-21
FI92589C (fi) 1994-12-12
PT86783A (pt) 1988-03-01
ATE81133T1 (de) 1992-10-15

Similar Documents

Publication Publication Date Title
ZA881030B (en) 19-nor steroids substituted in position 7,their preparation,application as medicaments,compositions containing them
AU582618B2 (en) New steroids substituted at position 10, the process and the intermediates for their preparation, their application as medicaments, the pharmaceutical compositions containing them
ES476786A1 (es) Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol.
NZ224367A (en) Insect and mite repelling agent containing at least one substituted #a#, #l#-aminoalcohol
ZA793453B (en) New 3,20-dioxo-4,9-diene-21-hydroxyl steroid derivatives,a process for preparing them,their use as medicaments and the pharmaceutical compositions containing them
AU6476394A (en) 19-nor steroids having a phenoxyalkylsulphonamide or phenoxyalkylsulphonylurea chain in position 11beta, preparation process and intermediates, use as medicaments and pharmaceutical compositions containing them
ES8609225A1 (es) Un procedimiento para preparar un derivado de semicarbazida
IE43847L (en) N-substituted phenylpiperidine derivatives.
GB1075251A (en) Cardenolide derivatives
NZ221137A (en) 14,17b-ethano-14b-estratrienes and pharmaceutical compositions
FI932641A0 (fi) Nytt estradiolderivat-klorambucil-konjugat, foerfarande foer dess framstaellning och farmaceutiska kompositioner
KR890009901A (ko) 3-히드록시-2-(4-메톡시페닐)-5-(2-메틸아미노에틸)-2,3-디히드로-5h-1,5- 벤조티아제핀-4-온 유도체, 그의 제조 및 치료에의 이용
IL110530A0 (en) 15, 15-Dialkyl-substituted derivatives of estradiol and pharmaceutical compositions thereof
ES8200648A2 (es) Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
AU559732B2 (en) Di-and-tetrahydroguinolylacetic acid esters
IE41219L (en) Aralkyl esters of aminoalkanoic acids
ES447094A1 (es) Procedimiento de preparacion de nuevos derivados de oxadia- zol.
AU6466890A (en) New derivatives substituted in position 15 of 20,21-dinoreburnamenine, their preparation process and the new intermediates thus obtained, their use as medicaments and the compositions containing them
AU528274B2 (en) Digoxin derivatives
KR890001527A (ko) 에이즈 및 에이즈 관련 복합증상의 억제를 위한 아바콘, 아바롤 및 그 유도체의 용도
GB2022583A (en) New ionic polyiodo benzene derivatives useful as X-ray contrast media