ZA87983B - Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity,process for their preparation and pharmaceutical compositions containing them - Google Patents

Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA87983B
ZA87983B ZA870983A ZA87983A ZA87983B ZA 87983 B ZA87983 B ZA 87983B ZA 870983 A ZA870983 A ZA 870983A ZA 87983 A ZA87983 A ZA 87983A ZA 87983 B ZA87983 B ZA 87983B
Authority
ZA
South Africa
Prior art keywords
nortropines
esters
alkyl
preparation
pharmaceutical compositions
Prior art date
Application number
ZA870983A
Other languages
English (en)
Inventor
Turbanti Luigi
Cerbai Guido
Original Assignee
Laboratori Guidotti S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Guidotti S.P.A. filed Critical Laboratori Guidotti S.P.A.
Publication of ZA87983B publication Critical patent/ZA87983B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA870983A 1986-02-11 1987-02-11 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity,process for their preparation and pharmaceutical compositions containing them ZA87983B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8619371A IT1213033B (it) 1986-02-11 1986-02-11 Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.

Publications (1)

Publication Number Publication Date
ZA87983B true ZA87983B (en) 1987-08-03

Family

ID=11157123

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA870983A ZA87983B (en) 1986-02-11 1987-02-11 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity,process for their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US4780467A (it)
EP (1) EP0234400B1 (it)
JP (1) JPH0723374B2 (it)
KR (1) KR940009783B1 (it)
AR (1) AR244225A1 (it)
AT (1) ATE58734T1 (it)
CA (1) CA1303043C (it)
DE (1) DE3766377D1 (it)
DK (1) DK170254B1 (it)
GR (1) GR3001228T3 (it)
IL (1) IL81519A0 (it)
IN (1) IN165884B (it)
IT (1) IT1213033B (it)
NO (1) NO166861C (it)
PH (1) PH25652A (it)
ZA (1) ZA87983B (it)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2706198A (en) * 1952-03-29 1955-04-12 Merck & Co Inc Benzhydryl ethers of tropine and processes of preparation
FR1444661A (fr) * 1960-10-18 1966-07-08 Egyt Gyogyszervegyeszeti Gyar Procédé de préparation de dérivés de p-alkyl-benzyl-tropinium
CH533082A (it) * 1967-10-07 1973-01-31 Guidotti & C Spa Labor Metodo di preparazione di prodotti ad attività antispastica e antiulcera
FR2168881A1 (en) * 1972-01-25 1973-09-07 Synthelabo Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics

Also Published As

Publication number Publication date
CA1303043C (en) 1992-06-09
KR870007929A (ko) 1987-09-23
NO166861B (no) 1991-06-03
DE3766377D1 (de) 1991-01-10
DK170254B1 (da) 1995-07-17
EP0234400B1 (en) 1990-11-28
IT8619371A0 (it) 1986-02-11
GR3001228T3 (en) 1992-07-30
DK66587A (da) 1987-08-12
IN165884B (it) 1990-02-03
EP0234400A1 (en) 1987-09-02
NO166861C (no) 1991-09-11
NO870515L (no) 1987-08-12
ATE58734T1 (de) 1990-12-15
DK66587D0 (da) 1987-02-10
KR940009783B1 (ko) 1994-10-17
NO870515D0 (no) 1987-02-10
AR244225A1 (es) 1993-10-29
IL81519A0 (en) 1987-09-16
JPH0723374B2 (ja) 1995-03-15
US4780467A (en) 1988-10-25
JPS62246572A (ja) 1987-10-27
PH25652A (en) 1991-08-21
IT1213033B (it) 1989-12-07

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