ZA877171B - A substance or composition comprising 3'-deoxythymidin-2'-ene(3'-deoxy-2',3'-didehydrothymidine)for use in treating patients infected with retroviruses - Google Patents
A substance or composition comprising 3'-deoxythymidin-2'-ene(3'-deoxy-2',3'-didehydrothymidine)for use in treating patients infected with retrovirusesInfo
- Publication number
- ZA877171B ZA877171B ZA877171A ZA877171A ZA877171B ZA 877171 B ZA877171 B ZA 877171B ZA 877171 A ZA877171 A ZA 877171A ZA 877171 A ZA877171 A ZA 877171A ZA 877171 B ZA877171 B ZA 877171B
- Authority
- ZA
- South Africa
- Prior art keywords
- deoxythymidin
- didehydrothymidine
- deoxy
- ene
- retroviruses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/942,666 US4978655A (en) | 1986-12-17 | 1986-12-17 | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA877171B true ZA877171B (en) | 1988-03-24 |
Family
ID=25478432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA877171A ZA877171B (en) | 1986-12-17 | 1987-09-23 | A substance or composition comprising 3'-deoxythymidin-2'-ene(3'-deoxy-2',3'-didehydrothymidine)for use in treating patients infected with retroviruses |
Country Status (22)
Country | Link |
---|---|
US (1) | US4978655A (de) |
EP (1) | EP0273277B1 (de) |
JP (1) | JPH07116041B2 (de) |
KR (1) | KR960000433B1 (de) |
AT (1) | ATE77554T1 (de) |
AU (1) | AU593405B2 (de) |
CA (1) | CA1293447C (de) |
DE (1) | DE3780016T2 (de) |
DK (1) | DK174627B1 (de) |
EG (1) | EG19157A (de) |
ES (1) | ES2038650T3 (de) |
FI (1) | FI875544A (de) |
GR (1) | GR3005691T3 (de) |
HK (1) | HK55896A (de) |
IE (1) | IE60866B1 (de) |
IL (1) | IL84790A (de) |
LU (1) | LU88822I2 (de) |
NL (1) | NL960024I2 (de) |
NZ (1) | NZ222935A (de) |
PH (1) | PH26380A (de) |
PT (1) | PT86346B (de) |
ZA (1) | ZA877171B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5631370A (en) * | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
US5175292A (en) * | 1988-01-20 | 1992-12-29 | Regents Of The University Of Minnesota | Intermediates for the preparation of dideoxycarbocyclic nucleosides |
FI95269C (fi) * | 1989-05-15 | 1996-01-10 | Squibb Bristol Myers Co | 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja |
US6207650B1 (en) | 1989-05-15 | 2001-03-27 | Bristol-Myers Squibb Company | Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine |
US5608048A (en) * | 1995-06-05 | 1997-03-04 | Bristol-Myers Squibb Company | d4 T polymorphic Form 1 process |
US5840711A (en) * | 1995-06-21 | 1998-11-24 | University Of Kentucky Research Foundation | Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome |
CA2189097A1 (en) | 1995-11-15 | 1997-05-16 | Pin-Fang Lin | Composition and method of treating retroviral infection |
US5719132A (en) * | 1996-06-27 | 1998-02-17 | Bristol-Myers Squibb Company | Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil |
WO2000016625A1 (en) * | 1998-09-23 | 2000-03-30 | University Of Kentucky Research Foundation | Antiviral drug compositions containing lithium inorganic salts |
EP1267879A2 (de) * | 2000-03-30 | 2003-01-02 | Bristol-Myers Squibb Company | Stavudinhaltige kügelchen mit verzögerter wirkstoffabgabe |
WO2003079972A2 (en) | 2002-02-22 | 2003-10-02 | New River Parmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
KR20110079783A (ko) * | 2003-02-19 | 2011-07-07 | 예일 유니버시티 | 항-바이러스 뉴클레오시드 유사체 및 바이러스 감염, 특히 에이치아이브이 감염의 치료방법 |
US20040200730A1 (en) * | 2003-04-14 | 2004-10-14 | Kyo Jibiki | Hydrometallurgical copper recovery process |
SI1778251T1 (sl) | 2004-07-27 | 2011-07-29 | Gilead Sciences Inc | Nukleozidni fosfonatni konjugati kot sredstva proti HIV |
DE602006017569D1 (de) * | 2005-08-31 | 2010-11-25 | Cipla Ltd | Pharmazeutische kombinationen mit lamivudin, stavudin und nevirapin |
WO2010077613A1 (en) | 2008-12-09 | 2010-07-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US20110223131A1 (en) | 2010-02-24 | 2011-09-15 | Gilead Sciences, Inc. | Antiviral compounds |
WO2016001907A1 (en) | 2014-07-02 | 2016-01-07 | Prendergast Patrick T | Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents. |
MA40238A (fr) | 2014-07-11 | 2017-05-17 | Gilead Sciences Inc | Modulateurs de récepteurs de type toll pour le traitement du vih |
US20170071944A1 (en) | 2015-09-15 | 2017-03-16 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3322747A (en) * | 1965-04-01 | 1967-05-30 | Merck & Co Inc | Thionocarbonate nucleosides |
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
JPS5943550B2 (ja) * | 1975-08-29 | 1984-10-23 | 田辺製薬株式会社 | 不飽和ヌクレオシドの製法 |
DE3515870A1 (de) * | 1985-05-03 | 1986-11-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 5-fluortoluol-2,4-disulfochlorid |
US4710492A (en) * | 1986-06-23 | 1987-12-01 | Yale University | 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses |
NL8700089A (nl) * | 1987-01-15 | 1988-08-01 | Stichting Rega V Z W | Therapeutische toepassing van dideoxythymidine en dideoxythymidineen. |
DE3806633A1 (de) * | 1987-09-01 | 1989-03-09 | Bayer Ag | Antivirales mittel |
JP2648329B2 (ja) * | 1987-09-18 | 1997-08-27 | エフ・ホフマン−ラ ロシュ アーゲー | エイズの予防または治療用医薬組成物 |
SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
JPH0227782A (ja) * | 1988-07-15 | 1990-01-30 | Hikari Gijutsu Kenkyu Kaihatsu Kk | 半導体発光素子 |
JPH0438727A (ja) * | 1990-06-04 | 1992-02-07 | Sharp Corp | 光学式ピックアップ装置の対物レンズ塵埃付着防止機構 |
-
1986
- 1986-12-17 US US06/942,666 patent/US4978655A/en not_active Expired - Lifetime
-
1987
- 1987-09-23 ZA ZA877171A patent/ZA877171B/xx unknown
- 1987-09-29 PH PH35869A patent/PH26380A/en unknown
- 1987-10-07 EG EG57787A patent/EG19157A/xx active
- 1987-10-23 DK DK198705570A patent/DK174627B1/da not_active IP Right Cessation
- 1987-11-06 AU AU80900/87A patent/AU593405B2/en not_active Expired
- 1987-11-24 JP JP62294251A patent/JPH07116041B2/ja not_active Expired - Lifetime
- 1987-11-30 IE IE324587A patent/IE60866B1/en not_active IP Right Cessation
- 1987-12-02 CA CA000553354A patent/CA1293447C/en not_active Expired - Lifetime
- 1987-12-11 EP EP87118407A patent/EP0273277B1/de not_active Expired - Lifetime
- 1987-12-11 IL IL84790A patent/IL84790A/xx not_active IP Right Cessation
- 1987-12-11 PT PT86346A patent/PT86346B/pt unknown
- 1987-12-11 DE DE8787118407T patent/DE3780016T2/de not_active Expired - Lifetime
- 1987-12-11 AT AT87118407T patent/ATE77554T1/de active
- 1987-12-11 ES ES198787118407T patent/ES2038650T3/es not_active Expired - Lifetime
- 1987-12-11 LU LU88822C patent/LU88822I2/fr unknown
- 1987-12-15 NZ NZ222935A patent/NZ222935A/xx unknown
- 1987-12-16 FI FI875544A patent/FI875544A/fi not_active Application Discontinuation
- 1987-12-17 KR KR1019870014383A patent/KR960000433B1/ko not_active IP Right Cessation
-
1992
- 1992-09-14 GR GR920402023T patent/GR3005691T3/el unknown
-
1996
- 1996-03-28 HK HK55896A patent/HK55896A/xx not_active IP Right Cessation
- 1996-10-07 NL NL960024C patent/NL960024I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
AU8090087A (en) | 1988-06-23 |
EP0273277A3 (en) | 1989-09-13 |
EP0273277B1 (de) | 1992-06-24 |
IE60866B1 (en) | 1994-08-24 |
AU593405B2 (en) | 1990-02-08 |
KR960000433B1 (ko) | 1996-01-06 |
GR3005691T3 (de) | 1993-06-07 |
NL960024I2 (nl) | 1997-06-02 |
NZ222935A (en) | 1990-09-26 |
US4978655A (en) | 1990-12-18 |
DK174627B1 (da) | 2003-07-28 |
FI875544A0 (fi) | 1987-12-16 |
JPS63215632A (ja) | 1988-09-08 |
DE3780016D1 (de) | 1992-07-30 |
HK55896A (en) | 1996-04-03 |
PH26380A (en) | 1992-06-01 |
IE873245L (en) | 1988-06-17 |
IL84790A0 (en) | 1988-05-31 |
JPH07116041B2 (ja) | 1995-12-13 |
DE3780016T2 (de) | 1992-12-24 |
DK557087A (da) | 1988-06-18 |
DK557087D0 (da) | 1987-10-23 |
PT86346B (pt) | 1990-11-07 |
ES2038650T3 (es) | 1993-08-01 |
EP0273277A2 (de) | 1988-07-06 |
NL960024I1 (nl) | 1996-12-02 |
CA1293447C (en) | 1991-12-24 |
KR880007079A (ko) | 1988-08-26 |
IL84790A (en) | 1993-03-15 |
ATE77554T1 (de) | 1992-07-15 |
PT86346A (en) | 1988-01-01 |
FI875544A (fi) | 1988-06-18 |
LU88822I2 (fr) | 1997-01-06 |
EG19157A (en) | 1994-09-29 |
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