ZA875513B - Novel 8-(lower alkyl)bicyclo(4.2.0)octane derivatives with valuable therapeutic properties - Google Patents
Novel 8-(lower alkyl)bicyclo(4.2.0)octane derivatives with valuable therapeutic propertiesInfo
- Publication number
- ZA875513B ZA875513B ZA875513A ZA875513A ZA875513B ZA 875513 B ZA875513 B ZA 875513B ZA 875513 A ZA875513 A ZA 875513A ZA 875513 A ZA875513 A ZA 875513A ZA 875513 B ZA875513 B ZA 875513B
- Authority
- ZA
- South Africa
- Prior art keywords
- lower alkyl
- chem
- bicyclo
- novel
- therapeutic properties
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 6
- RPZUBXWEQBPUJR-UHFFFAOYSA-N bicyclo[4.2.0]octane Chemical class C1CCCC2CCC21 RPZUBXWEQBPUJR-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/891,509 US4678805A (en) | 1985-03-27 | 1986-07-28 | Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties |
Publications (1)
Publication Number | Publication Date |
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ZA875513B true ZA875513B (en) | 1989-03-29 |
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ID=25398316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA875513A ZA875513B (en) | 1986-07-28 | 1987-07-27 | Novel 8-(lower alkyl)bicyclo(4.2.0)octane derivatives with valuable therapeutic properties |
Country Status (16)
Country | Link |
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US (1) | US4678805A (da) |
EP (1) | EP0255098B1 (da) |
JP (1) | JPS6345232A (da) |
KR (1) | KR880001561A (da) |
AT (1) | ATE63899T1 (da) |
AU (1) | AU605493B2 (da) |
DE (1) | DE3770360D1 (da) |
DK (1) | DK391087A (da) |
FI (1) | FI873271A (da) |
GR (1) | GR3002024T3 (da) |
HU (1) | HU197870B (da) |
IL (1) | IL83339A0 (da) |
NO (1) | NO166442C (da) |
NZ (1) | NZ221197A (da) |
PH (1) | PH24200A (da) |
ZA (1) | ZA875513B (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735966A (en) * | 1986-08-25 | 1988-04-05 | Syntex (U.S.A.) Inc. | Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties |
US5049497A (en) * | 1986-08-25 | 1991-09-17 | Syntex (U.S.A.) Inc. | Novel process for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives |
US4730078A (en) * | 1987-05-13 | 1988-03-08 | G. D. Searle & Co. | Allenic prostacyclins |
US4983627A (en) * | 1988-11-10 | 1991-01-08 | Syntex (U.S.A.) Inc. | Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives |
DE69409988T2 (de) * | 1993-02-10 | 1998-12-17 | Yutaka Giken K.K., Hamamatsu, Shizuoka | Schwimmend gelagerte Bremsscheibe |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
US4306076A (en) * | 1980-04-23 | 1981-12-15 | The Upjohn Company | Inter-phenylene CBA compounds |
US4608388A (en) * | 1985-03-27 | 1986-08-26 | Syntex (U.S.A.) Inc. | Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties |
US4735966A (en) * | 1986-08-25 | 1988-04-05 | Syntex (U.S.A.) Inc. | Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties |
-
1986
- 1986-07-28 US US06/891,509 patent/US4678805A/en not_active Expired - Fee Related
-
1987
- 1987-07-27 AT AT87110873T patent/ATE63899T1/de active
- 1987-07-27 EP EP87110873A patent/EP0255098B1/en not_active Expired - Lifetime
- 1987-07-27 NO NO873131A patent/NO166442C/no unknown
- 1987-07-27 KR KR1019870008179A patent/KR880001561A/ko not_active Application Discontinuation
- 1987-07-27 ZA ZA875513A patent/ZA875513B/xx unknown
- 1987-07-27 IL IL83339A patent/IL83339A0/xx unknown
- 1987-07-27 PH PH35587A patent/PH24200A/en unknown
- 1987-07-27 FI FI873271A patent/FI873271A/fi not_active Application Discontinuation
- 1987-07-27 AU AU76125/87A patent/AU605493B2/en not_active Expired - Fee Related
- 1987-07-27 NZ NZ221197A patent/NZ221197A/en unknown
- 1987-07-27 HU HU873418A patent/HU197870B/hu not_active IP Right Cessation
- 1987-07-27 DK DK391087A patent/DK391087A/da not_active Application Discontinuation
- 1987-07-27 JP JP62189963A patent/JPS6345232A/ja active Pending
- 1987-07-27 DE DE8787110873T patent/DE3770360D1/de not_active Expired - Fee Related
-
1991
- 1991-05-30 GR GR90401109T patent/GR3002024T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PH24200A (en) | 1990-04-10 |
HU197870B (en) | 1989-06-28 |
FI873271A0 (fi) | 1987-07-27 |
JPS6345232A (ja) | 1988-02-26 |
AU7612587A (en) | 1988-02-11 |
IL83339A0 (en) | 1987-12-31 |
US4678805A (en) | 1987-07-07 |
DK391087A (da) | 1988-01-29 |
FI873271A (fi) | 1988-01-29 |
AU605493B2 (en) | 1991-01-17 |
EP0255098B1 (en) | 1991-05-29 |
NO166442B (no) | 1991-04-15 |
HUT44471A (en) | 1988-03-28 |
DK391087D0 (da) | 1987-07-27 |
KR880001561A (ko) | 1988-04-25 |
NO873131D0 (no) | 1987-07-27 |
NO873131L (no) | 1988-01-29 |
GR3002024T3 (en) | 1992-12-30 |
ATE63899T1 (de) | 1991-06-15 |
EP0255098A1 (en) | 1988-02-03 |
DE3770360D1 (de) | 1991-07-04 |
NO166442C (no) | 1991-07-24 |
NZ221197A (en) | 1990-01-29 |
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