ZA871022B - Unsaturated amino acids - Google Patents

Unsaturated amino acids

Info

Publication number
ZA871022B
ZA871022B ZA871022A ZA871022A ZA871022B ZA 871022 B ZA871022 B ZA 871022B ZA 871022 A ZA871022 A ZA 871022A ZA 871022 A ZA871022 A ZA 871022A ZA 871022 B ZA871022 B ZA 871022B
Authority
ZA
South Africa
Prior art keywords
alkyl
amino
hydroxy
phosphono
pentenoic acid
Prior art date
Application number
ZA871022A
Inventor
Christof Angst
Angst Christof
Derek Edward Brundish
Edward Brundish Derek
John Grey Dingwall
Grey Dingwall John
Graham Eric Fagg
Eric Fagg Graham
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of ZA871022B publication Critical patent/ZA871022B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3217—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Abstract

Phosphorus-contg. unsaturated amino acids of formula (I) and their salts are new: R1 = hydroxy or etherified hydroxy; R2 = H, alkyl, hydroxy or etherified hydroxy; R3 = H, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl; R4 = H, alkyl or arl; R5 = H or alkyl; R6 = carboxy or esterified or amidated carboxy; R7 0 amino opt. substd. by alkyl or aryl; A = opt. alkyl-substd. 1-3C alpha, omega-alkylene or a direct bond; B = methyleue or direct bond; provided that A and B are both direct bonds. Specifically claimed are 9 cpds. including E-2-amino-5- phosphono-3-pentenoic acid, E-2-amino-4-methyl-5-phosphono -3-pentenoic acid, and E-2-amino-4-methyl -5-phosphono-3-pentenoic acid ethyl ester.
ZA871022A 1986-02-13 1987-02-12 Unsaturated amino acids ZA871022B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH57886 1986-02-13

Publications (1)

Publication Number Publication Date
ZA871022B true ZA871022B (en) 1987-09-30

Family

ID=4190244

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA871022A ZA871022B (en) 1986-02-13 1987-02-12 Unsaturated amino acids

Country Status (23)

Country Link
EP (1) EP0233154B1 (en)
JP (2) JPH0717665B2 (en)
KR (1) KR900003533B1 (en)
AT (1) ATE70535T1 (en)
AU (1) AU610493B2 (en)
CA (1) CA1331625C (en)
CY (1) CY1821A (en)
DD (1) DD263775A5 (en)
DE (1) DE3775229D1 (en)
DK (1) DK169341B1 (en)
ES (1) ES2038690T3 (en)
FI (1) FI85144C (en)
GR (1) GR3003526T3 (en)
HK (1) HK95594A (en)
HU (1) HU204532B (en)
IE (1) IE59417B1 (en)
IL (1) IL81543A0 (en)
NO (1) NO170938C (en)
NZ (1) NZ219255A (en)
PH (1) PH23762A (en)
PT (1) PT84270B (en)
SG (1) SG92294G (en)
ZA (1) ZA871022B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175344A (en) * 1986-02-13 1992-12-29 Ciba-Geigy Corporation Unsaturated amino acids
PT85874B (en) * 1986-10-09 1990-07-31 Ciba Geigy Ag PROCESS FOR THE PREPARATION OF OLIGO-PEPTIDES WITH ANTIBIOTIC ACTION
EP0302826A3 (en) * 1987-08-04 1991-04-03 Ciba-Geigy Ag Process for the preparation of unsaturated amino acid compounds
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
ES2060122T3 (en) * 1989-04-07 1994-11-16 Ciba Geigy Ag UNSATURATED DERIVATIVES OF AMINODICARBOXILIC ACIDS.
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
DK0420806T3 (en) * 1989-09-26 1995-10-16 Ciba Geigy Ag Phosphonic acids, processes for their preparation and their use as a drug
US5294734A (en) * 1989-09-26 1994-03-15 Ciba-Geigy Corp. 4-substituted 2-aminoalk-3-enoic acids
US5488140A (en) * 1989-09-26 1996-01-30 Ciba-Geigy Corporation 4-substituted 2-aminoalk-3-enoic
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
JPH07505908A (en) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Allosteric modulator of NMDA receptor
JP2009511624A (en) * 2005-10-18 2009-03-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） Hypophosphorous acid derivatives and therapeutic uses thereof
DE102007032669A1 (en) * 2007-07-13 2009-01-15 Clariant International Limited Alkylphosphonous acids, salts and esters, process for their preparation and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5387314A (en) * 1977-01-07 1978-08-01 Heiichi Sakai Nn14099substance
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use
US4477391A (en) * 1981-08-14 1984-10-16 Collins James F Amino acid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
AU6872687A (en) 1987-08-20
JPS62246586A (en) 1987-10-27
ATE70535T1 (en) 1992-01-15
IL81543A0 (en) 1987-09-16
NO170938C (en) 1992-12-30
FI870558A (en) 1987-08-14
JPH07206683A (en) 1995-08-08
KR900003533B1 (en) 1990-05-21
FI85144B (en) 1991-11-29
HU204532B (en) 1992-01-28
DK169341B1 (en) 1994-10-10
JP2509465B2 (en) 1996-06-19
SG92294G (en) 1995-04-28
HUT43863A (en) 1987-12-28
ES2038690T3 (en) 1993-08-01
DE3775229D1 (en) 1992-01-30
EP0233154A3 (en) 1989-06-14
FI870558A0 (en) 1987-02-11
CA1331625C (en) 1994-08-23
EP0233154A2 (en) 1987-08-19
HK95594A (en) 1994-09-16
DK70787D0 (en) 1987-02-12
NO870577L (en) 1987-08-14
DD263775A5 (en) 1989-01-11
AU610493B2 (en) 1991-05-23
JPH0717665B2 (en) 1995-03-01
PT84270A (en) 1987-03-01
KR870007942A (en) 1987-09-23
GR3003526T3 (en) 1993-03-16
IE870365L (en) 1987-08-13
NO170938B (en) 1992-09-21
DK70787A (en) 1987-08-14
FI85144C (en) 1992-03-10
NZ219255A (en) 1989-08-29
IE59417B1 (en) 1994-02-23
EP0233154B1 (en) 1991-12-18
CY1821A (en) 1995-10-20
PT84270B (en) 1989-09-14
NO870577D0 (en) 1987-02-13
PH23762A (en) 1989-11-03

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