PH23762A - Phosphono-acid-phosphino-aminoalenic acids - Google Patents

Phosphono-acid-phosphino-aminoalenic acids

Info

Publication number
PH23762A
PH23762A PH34860A PH34860A PH23762A PH 23762 A PH23762 A PH 23762A PH 34860 A PH34860 A PH 34860A PH 34860 A PH34860 A PH 34860A PH 23762 A PH23762 A PH 23762A
Authority
PH
Philippines
Prior art keywords
alkyl
phosphono
amino
hydroxy
pentenoic acid
Prior art date
Application number
PH34860A
Inventor
Christof Angst
Derek Edward Brundish
John Grey Dingwall
Graham Eric Fagg
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PH23762A publication Critical patent/PH23762A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3217—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Phosphorus-contg. unsaturated amino acids of formula (I) and their salts are new: R1 = hydroxy or etherified hydroxy; R2 = H, alkyl, hydroxy or etherified hydroxy; R3 = H, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl; R4 = H, alkyl or arl; R5 = H or alkyl; R6 = carboxy or esterified or amidated carboxy; R7 0 amino opt. substd. by alkyl or aryl; A = opt. alkyl-substd. 1-3C alpha, omega-alkylene or a direct bond; B = methyleue or direct bond; provided that A and B are both direct bonds. Specifically claimed are 9 cpds. including E-2-amino-5- phosphono-3-pentenoic acid, E-2-amino-4-methyl-5-phosphono -3-pentenoic acid, and E-2-amino-4-methyl -5-phosphono-3-pentenoic acid ethyl ester.
PH34860A 1986-02-13 1987-02-13 Phosphono-acid-phosphino-aminoalenic acids PH23762A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH57886 1986-02-13

Publications (1)

Publication Number Publication Date
PH23762A true PH23762A (en) 1989-11-03

Family

ID=4190244

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34860A PH23762A (en) 1986-02-13 1987-02-13 Phosphono-acid-phosphino-aminoalenic acids

Country Status (23)

Country Link
EP (1) EP0233154B1 (en)
JP (2) JPH0717665B2 (en)
KR (1) KR900003533B1 (en)
AT (1) ATE70535T1 (en)
AU (1) AU610493B2 (en)
CA (1) CA1331625C (en)
CY (1) CY1821A (en)
DD (1) DD263775A5 (en)
DE (1) DE3775229D1 (en)
DK (1) DK169341B1 (en)
ES (1) ES2038690T3 (en)
FI (1) FI85144C (en)
GR (1) GR3003526T3 (en)
HK (1) HK95594A (en)
HU (1) HU204532B (en)
IE (1) IE59417B1 (en)
IL (1) IL81543A0 (en)
NO (1) NO170938C (en)
NZ (1) NZ219255A (en)
PH (1) PH23762A (en)
PT (1) PT84270B (en)
SG (1) SG92294G (en)
ZA (1) ZA871022B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175344A (en) * 1986-02-13 1992-12-29 Ciba-Geigy Corporation Unsaturated amino acids
EP0263502A3 (en) * 1986-10-09 1990-05-02 Ciba-Geigy Ag Oligopeptide antibiotics
PH27591A (en) * 1987-08-04 1993-08-31 Ciba Geigy Ag A process for the manufacture of novel unsaturated amino acid compound
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
ES2060122T3 (en) * 1989-04-07 1994-11-16 Ciba Geigy Ag UNSATURATED DERIVATIVES OF AMINODICARBOXILIC ACIDS.
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5488140A (en) * 1989-09-26 1996-01-30 Ciba-Geigy Corporation 4-substituted 2-aminoalk-3-enoic
US5294734A (en) * 1989-09-26 1994-03-15 Ciba-Geigy Corp. 4-substituted 2-aminoalk-3-enoic acids
ATE124700T1 (en) * 1989-09-26 1995-07-15 Ciba Geigy Ag PHOSPHONIC ACID, METHOD FOR PRODUCTION AND USE AS A MEDICINAL ACTIVE INGREDIENT.
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
JPH07505908A (en) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Allosteric modulator of NMDA receptor
US20090170813A1 (en) * 2005-10-18 2009-07-02 Francine Acher Hypophosphorous Acid Derivatives and their Therapeutical Applications
DE102007032669A1 (en) 2007-07-13 2009-01-15 Clariant International Limited Alkylphosphonous acids, salts and esters, process for their preparation and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5387314A (en) * 1977-01-07 1978-08-01 Heiichi Sakai Nn14099substance
US4477391A (en) * 1981-08-14 1984-10-16 Collins James F Amino acid isomers, their production and their medicinal use
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
IL81543A0 (en) 1987-09-16
JPH07206683A (en) 1995-08-08
FI870558A (en) 1987-08-14
FI870558A0 (en) 1987-02-11
JPS62246586A (en) 1987-10-27
CY1821A (en) 1995-10-20
DK70787A (en) 1987-08-14
KR900003533B1 (en) 1990-05-21
NO870577L (en) 1987-08-14
DD263775A5 (en) 1989-01-11
HU204532B (en) 1992-01-28
AU610493B2 (en) 1991-05-23
DK70787D0 (en) 1987-02-12
PT84270A (en) 1987-03-01
EP0233154A2 (en) 1987-08-19
NO870577D0 (en) 1987-02-13
CA1331625C (en) 1994-08-23
GR3003526T3 (en) 1993-03-16
ZA871022B (en) 1987-09-30
PT84270B (en) 1989-09-14
EP0233154A3 (en) 1989-06-14
ATE70535T1 (en) 1992-01-15
HK95594A (en) 1994-09-16
NO170938C (en) 1992-12-30
JP2509465B2 (en) 1996-06-19
NZ219255A (en) 1989-08-29
FI85144C (en) 1992-03-10
KR870007942A (en) 1987-09-23
EP0233154B1 (en) 1991-12-18
JPH0717665B2 (en) 1995-03-01
NO170938B (en) 1992-09-21
ES2038690T3 (en) 1993-08-01
AU6872687A (en) 1987-08-20
IE870365L (en) 1987-08-13
SG92294G (en) 1995-04-28
FI85144B (en) 1991-11-29
IE59417B1 (en) 1994-02-23
DE3775229D1 (en) 1992-01-30
DK169341B1 (en) 1994-10-10
HUT43863A (en) 1987-12-28

Similar Documents

Publication Publication Date Title
IL81543A0 (en) Unsaturated amino acids
EE03999B1 (en) Use of fumaric acid derivatives
ES2057126T3 (en) TREATMENT METHOD OF CAQUEXIA AND SOME NEW COMPOUNDS TO USE IN THIS METHOD.
ES8702437A1 (en) Substituted tetrapeptides.
ES2058173T3 (en) DIOXIALQUILENARIL-DIHIDROPIRIDINAS, INTERMEDIATE PRODUCTS FOR ITS MANUFACTURE, PROCEDURES FOR ITS MANUFACTURE AND ITS USE.
FI853254L (en) FOERFARANDE FOER FRAMSTAELLNING AV NYA STEROIDER, VILKA AER SUBSTITUERADE I 10-STAELLNINGEN MED EN RADIKAL INNEHAOLLANDE EN DUBBEL- ELLER TREDUBBELBINDNING.
ZA873721B (en) Substituted 6-hydroxymethyl-carbapenem antibiotics,a process for the preparation thereof,and the use thereof
ATE32715T1 (en) PROCESS FOR THE PREPARATION OF B-((2METHYLPROPOXY)-METHYL>-N-PHENYL-N-(PHENYLMETHYL - 1-PYRROLIDINETHANAMINE.
GB1369577A (en) Indole-carboxylic acid derivatives
FI870057A0 (en) NYA TYRONINDERIVAT.
ES8107158A1 (en) Purification of L-aspartyl-L-phenylalanine alkyl esters.
ES476031A1 (en) Maleic acid halfamides having blood pressure raising activity
PT80187A (en) A process for the preparation of quinoline carboxylic acid derivatives
FR2244489A1 (en) 3-Halo-4-heterocyclic substd.-phenylalkanoic acids - their esters and salts with antiinflammatory activity
FR2442052A1 (en) Human glaucoma treatment with labetalol - which is an amino- and hydroxyalkyl substd. salicylamide
HUT40100A (en) Process for producing quinolin-carboxylic acid derivatives
FR2381041A1 (en) Antiulcer hydroxy-substd. di:carboxylic acid derivs. - prepd. e.g. by redn. of hydroxy-iso-canadenoic acid (BE 16.8.78)
HUT61521A (en) Process for producing glycineethyl ester hydrochloride