SG92294G - Unsaturated amino-acids - Google Patents

Unsaturated amino-acids

Info

Publication number
SG92294G
SG92294G SG92294A SG92294A SG92294G SG 92294 G SG92294 G SG 92294G SG 92294 A SG92294 A SG 92294A SG 92294 A SG92294 A SG 92294A SG 92294 G SG92294 G SG 92294G
Authority
SG
Singapore
Prior art keywords
alkyl
amino
hydroxy
phosphono
pentenoic acid
Prior art date
Application number
SG92294A
Inventor
Christof Dr Angst
Derek Edward Dr Brundish
John Grey Dr Dingwall
Graham Eric Dr Fagg
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Priority to SG92294A priority Critical patent/SG92294G/en
Publication of SG92294G publication Critical patent/SG92294G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3217—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Phosphorus-contg. unsaturated amino acids of formula (I) and their salts are new: R1 = hydroxy or etherified hydroxy; R2 = H, alkyl, hydroxy or etherified hydroxy; R3 = H, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl; R4 = H, alkyl or arl; R5 = H or alkyl; R6 = carboxy or esterified or amidated carboxy; R7 0 amino opt. substd. by alkyl or aryl; A = opt. alkyl-substd. 1-3C alpha, omega-alkylene or a direct bond; B = methyleue or direct bond; provided that A and B are both direct bonds. Specifically claimed are 9 cpds. including E-2-amino-5- phosphono-3-pentenoic acid, E-2-amino-4-methyl-5-phosphono -3-pentenoic acid, and E-2-amino-4-methyl -5-phosphono-3-pentenoic acid ethyl ester.
SG92294A 1986-02-13 1994-07-11 Unsaturated amino-acids SG92294G (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG92294A SG92294G (en) 1986-02-13 1994-07-11 Unsaturated amino-acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH57886 1986-02-13
SG92294A SG92294G (en) 1986-02-13 1994-07-11 Unsaturated amino-acids

Publications (1)

Publication Number Publication Date
SG92294G true SG92294G (en) 1995-04-28

Family

ID=4190244

Family Applications (1)

Application Number Title Priority Date Filing Date
SG92294A SG92294G (en) 1986-02-13 1994-07-11 Unsaturated amino-acids

Country Status (23)

Country Link
EP (1) EP0233154B1 (en)
JP (2) JPH0717665B2 (en)
KR (1) KR900003533B1 (en)
AT (1) ATE70535T1 (en)
AU (1) AU610493B2 (en)
CA (1) CA1331625C (en)
CY (1) CY1821A (en)
DD (1) DD263775A5 (en)
DE (1) DE3775229D1 (en)
DK (1) DK169341B1 (en)
ES (1) ES2038690T3 (en)
FI (1) FI85144C (en)
GR (1) GR3003526T3 (en)
HK (1) HK95594A (en)
HU (1) HU204532B (en)
IE (1) IE59417B1 (en)
IL (1) IL81543A0 (en)
NO (1) NO170938C (en)
NZ (1) NZ219255A (en)
PH (1) PH23762A (en)
PT (1) PT84270B (en)
SG (1) SG92294G (en)
ZA (1) ZA871022B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175344A (en) * 1986-02-13 1992-12-29 Ciba-Geigy Corporation Unsaturated amino acids
PT85874B (en) * 1986-10-09 1990-07-31 Ciba Geigy Ag PROCESS FOR THE PREPARATION OF OLIGO-PEPTIDES WITH ANTIBIOTIC ACTION
PH27591A (en) * 1987-08-04 1993-08-31 Ciba Geigy Ag A process for the manufacture of novel unsaturated amino acid compound
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
DE59007300D1 (en) * 1989-04-07 1994-11-03 Ciba Geigy Ag Unsaturated aminodicarboxylic acid derivatives.
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5488140A (en) * 1989-09-26 1996-01-30 Ciba-Geigy Corporation 4-substituted 2-aminoalk-3-enoic
DE59009368D1 (en) * 1989-09-26 1995-08-10 Ciba Geigy Ag Phosphonic acid, process for its manufacture and use as an active pharmaceutical ingredient.
US5294734A (en) * 1989-09-26 1994-03-15 Ciba-Geigy Corp. 4-substituted 2-aminoalk-3-enoic acids
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
JPH07505908A (en) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Allosteric modulator of NMDA receptor
WO2007052169A2 (en) * 2005-10-18 2007-05-10 Centre National De La Recherche Scientifique (Cnrs) Hypophosphorous acid derivatives and their therapeutical applications
DE102007032669A1 (en) * 2007-07-13 2009-01-15 Clariant International Limited Alkylphosphonous acids, salts and esters, process for their preparation and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5387314A (en) * 1977-01-07 1978-08-01 Heiichi Sakai Nn14099substance
US4477391A (en) 1981-08-14 1984-10-16 Collins James F Amino acid isomers, their production and their medicinal use
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
DD263775A5 (en) 1989-01-11
NO870577L (en) 1987-08-14
CA1331625C (en) 1994-08-23
NO170938B (en) 1992-09-21
GR3003526T3 (en) 1993-03-16
DK70787D0 (en) 1987-02-12
HK95594A (en) 1994-09-16
DK169341B1 (en) 1994-10-10
FI85144B (en) 1991-11-29
JPH0717665B2 (en) 1995-03-01
IE59417B1 (en) 1994-02-23
NO170938C (en) 1992-12-30
HUT43863A (en) 1987-12-28
PT84270A (en) 1987-03-01
KR870007942A (en) 1987-09-23
IE870365L (en) 1987-08-13
CY1821A (en) 1995-10-20
JPS62246586A (en) 1987-10-27
FI85144C (en) 1992-03-10
AU6872687A (en) 1987-08-20
EP0233154B1 (en) 1991-12-18
ES2038690T3 (en) 1993-08-01
DK70787A (en) 1987-08-14
IL81543A0 (en) 1987-09-16
HU204532B (en) 1992-01-28
EP0233154A2 (en) 1987-08-19
FI870558A0 (en) 1987-02-11
KR900003533B1 (en) 1990-05-21
NZ219255A (en) 1989-08-29
ZA871022B (en) 1987-09-30
JP2509465B2 (en) 1996-06-19
DE3775229D1 (en) 1992-01-30
NO870577D0 (en) 1987-02-13
ATE70535T1 (en) 1992-01-15
PH23762A (en) 1989-11-03
PT84270B (en) 1989-09-14
JPH07206683A (en) 1995-08-08
AU610493B2 (en) 1991-05-23
EP0233154A3 (en) 1989-06-14
FI870558A (en) 1987-08-14

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