ZA869059B - Novel tetrahydroisoquinoline derivatives - Google Patents

Novel tetrahydroisoquinoline derivatives

Info

Publication number
ZA869059B
ZA869059B ZA869059A ZA869059A ZA869059B ZA 869059 B ZA869059 B ZA 869059B ZA 869059 A ZA869059 A ZA 869059A ZA 869059 A ZA869059 A ZA 869059A ZA 869059 B ZA869059 B ZA 869059B
Authority
ZA
South Africa
Prior art keywords
tetrahydroisoquinoline derivatives
novel tetrahydroisoquinoline
novel
derivatives
tetrahydroisoquinoline
Prior art date
Application number
ZA869059A
Other languages
English (en)
Inventor
Robin D Clark
Joseph M Muchowski
Fang-Ting Chiu
John O Gardner
Jacob Berger
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA869059B publication Critical patent/ZA869059B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA869059A 1985-12-02 1986-12-01 Novel tetrahydroisoquinoline derivatives ZA869059B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/803,464 US4613606A (en) 1985-12-02 1985-12-02 Tetrahydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
ZA869059B true ZA869059B (en) 1988-07-27

Family

ID=25186568

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA869059A ZA869059B (en) 1985-12-02 1986-12-01 Novel tetrahydroisoquinoline derivatives

Country Status (5)

Country Link
US (1) US4613606A (xx)
JP (1) JPS62155247A (xx)
CS (1) CS269989B2 (xx)
SU (2) SU1598875A3 (xx)
ZA (1) ZA869059B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667038A (en) * 1985-12-02 1987-05-19 Syntex (U.S.A.) Inc. Tetrahydroisoquinoline derivatives
US4978793A (en) * 1988-06-23 1990-12-18 W. R. Grace & Co.-Conn. Novel process for the preparation of serinol
US5135944A (en) * 1989-06-21 1992-08-04 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure
US5100912A (en) * 1990-05-14 1992-03-31 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives as dopamine agonists
US5093355A (en) * 1989-10-30 1992-03-03 Syntex (U.S.A.) Inc. Benzylpyrrolidine derivatives as dopamine agonists
CA2061260A1 (en) * 1991-02-27 1992-08-28 Kiyofumi Ishikawa Isoquinoline derivatives
US5362736A (en) * 1991-02-27 1994-11-08 Banyu Pharmaceutical Co., Ltd. Isoquinoline derivatives
DE19719817A1 (de) * 1997-05-13 1998-11-19 Hoechst Ag Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
AU2002211621A1 (en) 2000-10-10 2002-04-22 Calyx Therapeutics, Inc. Tricyclic compounds and uses thereof
US8440695B2 (en) * 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1802804A1 (de) * 1968-10-12 1970-06-11 Knoll Ag 1-[3'-Cyan-3'-(2'',3''-dimethoxyphenyl)-4'-methylpentyl]-2-methyl-6,7-dimethoxy-1,2,3,4-Tetrahydroisochinolin
DE2854210C2 (de) * 1978-12-15 1984-08-09 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von aromatisch oder heteroaromatisch substituierten Acetonitrilen

Also Published As

Publication number Publication date
US4613606A (en) 1986-09-23
SU1591806A3 (ru) 1990-09-07
CS269989B2 (en) 1990-05-14
JPS62155247A (ja) 1987-07-10
CS881786A2 (en) 1989-09-12
SU1598875A3 (ru) 1990-10-07

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