ZA867768B - Process for the preparation of stabilized isosorbide-5-mononitrate tablets,being also of sustained release,and formulation thus obtained - Google Patents
Process for the preparation of stabilized isosorbide-5-mononitrate tablets,being also of sustained release,and formulation thus obtainedInfo
- Publication number
- ZA867768B ZA867768B ZA867768A ZA867768A ZA867768B ZA 867768 B ZA867768 B ZA 867768B ZA 867768 A ZA867768 A ZA 867768A ZA 867768 A ZA867768 A ZA 867768A ZA 867768 B ZA867768 B ZA 867768B
- Authority
- ZA
- South Africa
- Prior art keywords
- isosorbide
- stabilized
- formulation
- preparation
- mononitrate
- Prior art date
Links
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 title abstract 3
- 229960003827 isosorbide mononitrate Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 239000006104 solid solution Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22493/85A IT1187750B (it) | 1985-10-15 | 1985-10-15 | Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA867768B true ZA867768B (en) | 1987-06-24 |
Family
ID=11197007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA867768A ZA867768B (en) | 1985-10-15 | 1986-10-14 | Process for the preparation of stabilized isosorbide-5-mononitrate tablets,being also of sustained release,and formulation thus obtained |
Country Status (12)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE64726B1 (en) * | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| IT1237638B (it) * | 1989-10-25 | 1993-06-12 | Ghirardi Paolo E. | Impiego dell'isosorbide 2-mononitrato per la preparazione di composi- zioni farmaceutiche atte al trattamento dell'angina pectoris |
| FR2666506A1 (fr) * | 1990-09-07 | 1992-03-13 | Pf Medicament | Comprime a liberation prolongee a base de 5-mononitrate d'isosorbide et son procede de preparation. |
| FR2677886B1 (fr) * | 1991-06-18 | 1995-03-31 | Adir | Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale. |
| IT1251114B (it) * | 1991-07-26 | 1995-05-04 | Farcon Ag | Forme farmaceutiche antivirali per applicazione vaginale |
| DE4313726A1 (de) * | 1993-04-27 | 1994-11-03 | Byk Nederland Bv | Feste Darreichungsform |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6676967B1 (en) * | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US20060263428A1 (en) * | 1993-09-20 | 2006-11-23 | Eugenio Cefali | Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics |
| DE19515972A1 (de) * | 1995-05-02 | 1996-11-07 | Bayer Ag | Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung |
| US5900425A (en) * | 1995-05-02 | 1999-05-04 | Bayer Aktiengesellschaft | Pharmaceutical preparations having controlled release of active compound and processes for their preparation |
| AU3861397A (en) * | 1996-08-02 | 1998-02-25 | Cal International Limited | Controlled release tablet formulation of isosorbide-5-mononitrate |
| US5851555A (en) * | 1997-08-15 | 1998-12-22 | Fuisz Technologies Ltd. | Controlled release dosage forms containing water soluble drugs |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| JP4696210B2 (ja) * | 2000-06-07 | 2011-06-08 | トーアエイヨー株式会社 | イソソルビド‐５‐モノニトレートを有効成分とする徐放性錠剤及びその製造方法 |
| JP4840549B2 (ja) * | 2000-11-20 | 2011-12-21 | トーアエイヨー株式会社 | 安定な血管拡張剤及びその製造方法 |
| US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| CN101442982B (zh) * | 2006-03-16 | 2012-07-18 | 格莱克劳吉克有限公司 | 用于诱导饱满感的包含优选处理过的淀粉的胃漂浮物组合物 |
| CN111068644B (zh) * | 2019-12-20 | 2023-01-03 | 中海油天津化工研究设计院有限公司 | 一种均四甲苯氧化制均酐催化剂及其制备方法 |
| CN115487162B (zh) * | 2022-10-13 | 2023-10-13 | 山东力诺制药有限公司 | 一种单硝酸异山梨酯缓释片的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2301664C3 (de) * | 1973-01-13 | 1979-07-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel |
| US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
| US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| IL61721A (en) * | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3325652A1 (de) * | 1983-07-15 | 1985-01-24 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung |
| JPS60181052A (ja) * | 1984-02-29 | 1985-09-14 | Tooa Eiyoo Kk | 安定なイソソルビド硝酸エステル組成物及びその製造法 |
-
1985
- 1985-10-15 IT IT22493/85A patent/IT1187750B/it active
-
1986
- 1986-10-02 EP EP86201705A patent/EP0219161B1/en not_active Expired - Lifetime
- 1986-10-02 AT AT86201705T patent/ATE71290T1/de not_active IP Right Cessation
- 1986-10-02 DE DE8686201705T patent/DE3683342D1/de not_active Expired - Lifetime
- 1986-10-02 ES ES198686201705T patent/ES2035819T3/es not_active Expired - Lifetime
- 1986-10-13 JP JP61241570A patent/JPS62123114A/ja active Granted
- 1986-10-13 AU AU63831/86A patent/AU591185B2/en not_active Ceased
- 1986-10-14 CA CA000520377A patent/CA1285489C/en not_active Expired - Lifetime
- 1986-10-14 ZA ZA867768A patent/ZA867768B/xx unknown
- 1986-10-14 US US06/918,385 patent/US4812316A/en not_active Expired - Lifetime
-
1992
- 1992-04-07 GR GR920400639T patent/GR3004285T3/el unknown
-
1995
- 1995-01-26 HK HK12295A patent/HK12295A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3683342D1 (de) | 1992-02-20 |
| JPS62123114A (ja) | 1987-06-04 |
| CA1285489C (en) | 1991-07-02 |
| HK12295A (en) | 1995-02-03 |
| GR3004285T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-03-31 |
| EP0219161B1 (en) | 1992-01-08 |
| EP0219161A2 (en) | 1987-04-22 |
| JPH0524888B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-09 |
| IT1187750B (it) | 1987-12-23 |
| US4812316A (en) | 1989-03-14 |
| ES2035819T3 (es) | 1993-05-01 |
| AU6383186A (en) | 1987-04-16 |
| EP0219161A3 (en) | 1988-01-13 |
| IT8522493A0 (it) | 1985-10-15 |
| AU591185B2 (en) | 1989-11-30 |
| ATE71290T1 (de) | 1992-01-15 |
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