ZA861915B - Beta-lactam antibiotics processes for their preparation and their use as medicaments - Google Patents
Beta-lactam antibiotics processes for their preparation and their use as medicamentsInfo
- Publication number
- ZA861915B ZA861915B ZA861915A ZA861915A ZA861915B ZA 861915 B ZA861915 B ZA 861915B ZA 861915 A ZA861915 A ZA 861915A ZA 861915 A ZA861915 A ZA 861915A ZA 861915 B ZA861915 B ZA 861915B
- Authority
- ZA
- South Africa
- Prior art keywords
- image
- beta
- medicaments
- processes
- preparation
- Prior art date
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- -1 beta -lactam compounds Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/70—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853509618 DE3509618A1 (de) | 1985-03-16 | 1985-03-16 | Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA861915B true ZA861915B (en) | 1986-11-26 |
Family
ID=6265496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA861915A ZA861915B (en) | 1985-03-16 | 1986-03-14 | Beta-lactam antibiotics processes for their preparation and their use as medicaments |
Country Status (19)
Country | Link |
---|---|
US (1) | US4734407A (fi) |
EP (1) | EP0197294B1 (fi) |
JP (1) | JPS61215395A (fi) |
KR (1) | KR860007268A (fi) |
CN (1) | CN1015262B (fi) |
AT (1) | ATE62245T1 (fi) |
AU (1) | AU589950B2 (fi) |
CA (1) | CA1280408C (fi) |
DD (1) | DD246993A5 (fi) |
DE (2) | DE3509618A1 (fi) |
DK (1) | DK118386A (fi) |
ES (1) | ES8705452A1 (fi) |
FI (1) | FI85025C (fi) |
GR (1) | GR860708B (fi) |
HU (1) | HU195663B (fi) |
IL (1) | IL78137A (fi) |
NO (1) | NO860726L (fi) |
PT (1) | PT82203B (fi) |
ZA (1) | ZA861915B (fi) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3713872A1 (de) * | 1987-04-25 | 1988-11-17 | Hoechst Ag | Substituierte chinoxalyl-imidazolidin-2,4-dione, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate |
US5171854A (en) * | 1987-05-26 | 1992-12-15 | Bayer Aktiengesellschaft | Substituted vinylcephalosporins |
DE3733626A1 (de) * | 1987-10-05 | 1989-04-13 | Bayer Ag | Heteroanellierte phenylglycin-(beta)-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3803169A1 (de) * | 1988-02-03 | 1989-08-17 | Bayer Ag | Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln |
US5114929A (en) * | 1989-03-21 | 1992-05-19 | Beecham Group P.L.C. | Pharmaceutical formulation |
DE4411657A1 (de) * | 1994-04-02 | 1995-10-05 | Basf Ag | Verfahren zur Herstellung von 6-Hydroxymethylchinolinen |
DE4443892A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate |
US20100234386A1 (en) * | 2007-05-10 | 2010-09-16 | Chaudhari Amita | Quinoxaline derivatives as pi3 kinase inhibitors |
CA2716347C (en) * | 2008-02-21 | 2017-06-20 | Sequoia Pharmaceuticals, Inc. | Amino acid inhibitors of cytochrome p450 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3080356A (en) * | 1960-06-15 | 1963-03-05 | Beecham Res Lab | Process for the production of synthetic penicillins |
SE302125B (fi) | 1961-03-23 | 1968-07-08 | Bristol Myers Co | |
GB1174335A (en) | 1967-03-07 | 1969-12-17 | Lilly Co Eli | 7-Alpha-Amino-3-Methyl Cephalosporin Analogues, Pharmaceutical Compositions comprising the same and processes for preparing the same |
ES401263A1 (es) | 1972-03-28 | 1975-02-16 | Beecham Group Ltd | Un procedimiento para la produccion de alfa - amino-(p-hi- droxibencil) penicilina. |
YU36970B (en) | 1973-02-23 | 1984-08-31 | Lilly Co Eli | Process for obtaining 7-(amino)-acylamido-3-halocephalosporins |
US3925372A (en) | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
IL52144A (en) | 1976-07-01 | 1979-10-31 | Lilly Co Eli | De-esterification process for -lactam antibiotic esters |
GB1546622A (en) | 1976-12-09 | 1979-05-23 | Beecham Group Ltd | Bisnor penicillanic acid derivatives methods for their preparation and compositions containing |
DE2857696C2 (de) * | 1977-07-23 | 1984-08-30 | Toyama Chemical Co. Ltd., Tokio / Tokyo | Cephalosporine |
US4229575A (en) * | 1978-02-27 | 1980-10-21 | Richardson-Merrell Inc. | 7-(2,3-Dihydrobenzo-5-furanyl)-acetamido cephalosporin derivatives |
US4138397A (en) * | 1978-02-27 | 1979-02-06 | Richardson-Merrell Inc. | 6-(2,3-Dihydro-5-benzofuranyl)acetamido penicillin derivatives |
US4219648A (en) * | 1978-03-06 | 1980-08-26 | Richardson-Merrell Inc. | 7-[[Amino(1,3-dihydrobenzo[c]thienyl)acetyl]amino]cephalosporin derivatives |
US4461767A (en) * | 1978-06-16 | 1984-07-24 | E. R. Squibb & Sons, Inc. | Iminothiazolyl ureido cephalosporins |
US4317775A (en) * | 1980-01-07 | 1982-03-02 | Hoffmann-La Roche Inc. | Amoxicillin derivatives |
FR2511375A1 (fr) * | 1981-08-17 | 1983-02-18 | Rhone Poulenc Sante | Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent |
US4537886A (en) * | 1982-03-31 | 1985-08-27 | Beecham Group P.L.C. | β-lactam antibacterial agents and compositions containing them |
EP0121499A3 (de) * | 1983-03-31 | 1985-09-25 | Ciba-Geigy Ag | 7Beta-Acylamido-3-cephem-4-carbonsäureverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren |
US4492694A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Indolylglycyl cephalosporin derivatives |
US4501741A (en) * | 1983-04-12 | 1985-02-26 | Eli Lilly And Company | Cephalosporin antibiotics |
DE3508258A1 (de) * | 1985-03-08 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln |
-
1985
- 1985-03-16 DE DE19853509618 patent/DE3509618A1/de not_active Withdrawn
-
1986
- 1986-02-27 NO NO860726A patent/NO860726L/no unknown
- 1986-03-03 DE DE8686102770T patent/DE3678478D1/de not_active Expired - Lifetime
- 1986-03-03 AT AT86102770T patent/ATE62245T1/de not_active IP Right Cessation
- 1986-03-03 EP EP86102770A patent/EP0197294B1/de not_active Expired - Lifetime
- 1986-03-10 US US06/838,236 patent/US4734407A/en not_active Expired - Fee Related
- 1986-03-13 AU AU54722/86A patent/AU589950B2/en not_active Ceased
- 1986-03-13 IL IL78137A patent/IL78137A/xx unknown
- 1986-03-13 FI FI861045A patent/FI85025C/fi not_active IP Right Cessation
- 1986-03-14 CA CA000504079A patent/CA1280408C/en not_active Expired - Lifetime
- 1986-03-14 ES ES553033A patent/ES8705452A1/es not_active Expired
- 1986-03-14 PT PT82203A patent/PT82203B/pt not_active IP Right Cessation
- 1986-03-14 DD DD86287907A patent/DD246993A5/de not_active IP Right Cessation
- 1986-03-14 GR GR860708A patent/GR860708B/el unknown
- 1986-03-14 ZA ZA861915A patent/ZA861915B/xx unknown
- 1986-03-14 HU HU861077A patent/HU195663B/hu not_active IP Right Cessation
- 1986-03-14 DK DK118386A patent/DK118386A/da not_active Application Discontinuation
- 1986-03-15 CN CN86101695A patent/CN1015262B/zh not_active Expired
- 1986-03-15 KR KR1019860001893A patent/KR860007268A/ko not_active Application Discontinuation
- 1986-03-15 JP JP61056103A patent/JPS61215395A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0197294A3 (en) | 1988-05-04 |
FI861045A0 (fi) | 1986-03-13 |
DD246993A5 (de) | 1987-06-24 |
FI861045A (fi) | 1986-09-17 |
DK118386A (da) | 1986-09-17 |
DK118386D0 (da) | 1986-03-14 |
GR860708B (en) | 1986-07-15 |
JPS61215395A (ja) | 1986-09-25 |
FI85025B (fi) | 1991-11-15 |
CA1280408C (en) | 1991-02-19 |
HU195663B (en) | 1988-06-28 |
CN86101695A (zh) | 1986-09-10 |
KR860007268A (ko) | 1986-10-10 |
HUT41032A (en) | 1987-03-30 |
PT82203B (pt) | 1988-07-29 |
EP0197294B1 (de) | 1991-04-03 |
CN1015262B (zh) | 1992-01-01 |
AU589950B2 (en) | 1989-10-26 |
IL78137A (en) | 1991-03-10 |
DE3678478D1 (de) | 1991-05-08 |
ES8705452A1 (es) | 1987-05-01 |
ATE62245T1 (de) | 1991-04-15 |
IL78137A0 (en) | 1986-07-31 |
EP0197294A2 (de) | 1986-10-15 |
US4734407A (en) | 1988-03-29 |
PT82203A (en) | 1986-04-01 |
DE3509618A1 (de) | 1986-09-18 |
FI85025C (fi) | 1992-02-25 |
NO860726L (no) | 1986-09-17 |
ES553033A0 (es) | 1987-05-01 |
AU5472286A (en) | 1986-09-18 |
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