ZA86174B - Anti-inflammatory guanidines - Google Patents

Anti-inflammatory guanidines

Info

Publication number
ZA86174B
ZA86174B ZA86174A ZA86174A ZA86174B ZA 86174 B ZA86174 B ZA 86174B ZA 86174 A ZA86174 A ZA 86174A ZA 86174 A ZA86174 A ZA 86174A ZA 86174 B ZA86174 B ZA 86174B
Authority
ZA
South Africa
Prior art keywords
phenyl
sub
alkyl
substituted
guanidines
Prior art date
Application number
ZA86174A
Other languages
English (en)
Inventor
Peter Harold Nelson
Stefan Howard Unger
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA86174B publication Critical patent/ZA86174B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/46Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA86174A 1985-01-10 1986-01-09 Anti-inflammatory guanidines ZA86174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/690,295 US4680300A (en) 1985-01-10 1985-01-10 Anti-inflammatory guanidines

Publications (1)

Publication Number Publication Date
ZA86174B true ZA86174B (en) 1987-08-26

Family

ID=24771908

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA86174A ZA86174B (en) 1985-01-10 1986-01-09 Anti-inflammatory guanidines

Country Status (10)

Country Link
US (1) US4680300A (xx)
EP (1) EP0188333B1 (xx)
JP (1) JPS61191668A (xx)
AT (1) ATE44729T1 (xx)
AU (1) AU5216586A (xx)
DE (1) DE3664463D1 (xx)
DK (1) DK10086A (xx)
ES (1) ES8703410A1 (xx)
NZ (1) NZ214779A (xx)
ZA (1) ZA86174B (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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IT1205640B (it) * 1983-04-06 1989-03-23 Yason Srl Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
JPH0655730B2 (ja) * 1987-07-17 1994-07-27 ザ ヌトラスウィート カンパニー 強力甘味剤
US4900740A (en) * 1987-10-02 1990-02-13 The Nutrasweet Company N,N'-disubstituted guanidines containing a carboxyl or a tetrazolyl moiety
US4870210A (en) * 1987-12-18 1989-09-26 American Home Products Corporation Aminoguanidine derivative as anti-inflammatory agents
IN172842B (xx) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
JP2527859Y2 (ja) * 1991-05-14 1997-03-05 ナショナル住宅産業株式会社 切削装置
US5565216A (en) * 1993-07-21 1996-10-15 Carson Products Company Hair relaxer compositions
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
EP0979226B1 (en) * 1997-04-21 2005-11-09 Sumitomo Pharmaceuticals Company, Limited Isoxazole derivatives
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
DE19748696A1 (de) * 1997-11-04 1999-05-06 Basf Ag Verfahren zur Herstellung von substituierten Guanidinderivaten
EP1413302A3 (en) * 1999-07-21 2004-05-12 Kadmus Pharmaceuticals, Inc. Substituted guanidines for the treatment of pain
US6875759B1 (en) 1999-07-21 2005-04-05 Kadmus Pharmaceuticals Substituted guanidines and the use thereof
EP1202718A2 (en) * 1999-07-21 2002-05-08 Kadmus Pharmaceuticals, Inc. Substituted guanidines for the treatment of cancer and pain
DE10149919A1 (de) 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
WO2014015157A2 (en) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases
WO2022015974A2 (en) * 2020-07-15 2022-01-20 St. Jude Children's Research Hospital, Inc. Substituted 4-(3-aminoprop-1-yl)aminoquinoline analogs as modulators of melanoma-associated antigen 11 ubiquitin ligase

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GB129443A (en) * 1918-07-11 1919-07-11 Climax Rock Drill & Engineerin Improvements in Valve Gear for Rock Drills and other Percussion Tools.
DE831100C (de) * 1948-10-19 1952-02-11 Farbwerke Hoechst Vormals Meis Verfahren zur Herstellung von Guanylhydrazonen der 4-Aminochinolinreihe
US3474134A (en) * 1960-03-03 1969-10-21 Burroughs Wellcome Co Phenoxyethyl-guanidines and the salts thereof
US3159679A (en) * 1960-12-28 1964-12-01 Union Carbide Corp Oxo recovery process
GB1016071A (en) * 1961-02-15 1966-01-05 Smith Kline French Lab New guanidine derivatives and process for preparing the same
GB972888A (en) * 1961-11-23 1964-10-21 Farmaceutici Italia New 2-amino-(mono- or di-substituted)-ethyl-guanidines
GB1026402A (en) * 1961-12-12 1966-04-20 Wellcome Found Substituted guanidines
US3159676A (en) * 1962-02-07 1964-12-01 Smith Kline French Lab Naphthyl containing guanidines
GB1049285A (en) * 1962-05-14 1966-11-23 Smith Kline French Lab Guanidine and dihydroimidazole derivatives
SE321464B (xx) * 1962-08-23 1970-03-09 Pharmacia Ab
US3209023A (en) * 1963-01-02 1965-09-28 Burroughs Wellcome Co Substituted phenoxyethylguanidines
GB1007844A (en) * 1963-08-21 1965-10-22 Pfizer Ltd Guanidine derivatives
US3456058A (en) * 1964-03-03 1969-07-15 Upjohn Co Aralkoxyguanidines,aryloxyalkoxyguanidines and salts thereof in anorectic methods and compositions
US3246031A (en) * 1965-02-23 1966-04-12 Parke Davis & Co Phenoxypropylguanidine compounds
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
US3574744A (en) * 1967-10-26 1971-04-13 Squibb & Sons Inc Guanidinoalkyl derivatives of substituted anilides
ZA694133B (en) * 1968-08-27 1971-01-27 Colgate Palmolive Co Aryloxyalkylguanidines
SE418800B (sv) * 1975-11-13 1981-06-29 Sandoz Ag Forfarande for framstellning av nya antihypertensiva preparat
GB1604674A (en) * 1977-05-17 1981-12-16 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs

Also Published As

Publication number Publication date
DK10086D0 (da) 1986-01-09
EP0188333B1 (en) 1989-07-19
ATE44729T1 (de) 1989-08-15
US4680300A (en) 1987-07-14
ES8703410A1 (es) 1987-03-01
DK10086A (da) 1986-07-11
JPS61191668A (ja) 1986-08-26
NZ214779A (en) 1989-08-29
EP0188333A1 (en) 1986-07-23
AU5216586A (en) 1986-07-17
DE3664463D1 (en) 1989-08-24
ES550769A0 (es) 1987-03-01

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