ATE44729T1 - Entzuendungshemmende guanidine, deren herstellung und diese enthaltende zusammensetzungen. - Google Patents

Entzuendungshemmende guanidine, deren herstellung und diese enthaltende zusammensetzungen.

Info

Publication number
ATE44729T1
ATE44729T1 AT86300123T AT86300123T ATE44729T1 AT E44729 T1 ATE44729 T1 AT E44729T1 AT 86300123 T AT86300123 T AT 86300123T AT 86300123 T AT86300123 T AT 86300123T AT E44729 T1 ATE44729 T1 AT E44729T1
Authority
AT
Austria
Prior art keywords
phenyl
sub
guanidines
inflammatory
preparation
Prior art date
Application number
AT86300123T
Other languages
English (en)
Inventor
Peter H Nelson
Stefan H Unger
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE44729T1 publication Critical patent/ATE44729T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT86300123T 1985-01-10 1986-01-09 Entzuendungshemmende guanidine, deren herstellung und diese enthaltende zusammensetzungen. ATE44729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/690,295 US4680300A (en) 1985-01-10 1985-01-10 Anti-inflammatory guanidines
EP86300123A EP0188333B1 (de) 1985-01-10 1986-01-09 Entzündungshemmende Guanidine, deren Herstellung und diese enthaltende Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE44729T1 true ATE44729T1 (de) 1989-08-15

Family

ID=24771908

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86300123T ATE44729T1 (de) 1985-01-10 1986-01-09 Entzuendungshemmende guanidine, deren herstellung und diese enthaltende zusammensetzungen.

Country Status (10)

Country Link
US (1) US4680300A (de)
EP (1) EP0188333B1 (de)
JP (1) JPS61191668A (de)
AT (1) ATE44729T1 (de)
AU (1) AU5216586A (de)
DE (1) DE3664463D1 (de)
DK (1) DK10086A (de)
ES (1) ES8703410A1 (de)
NZ (1) NZ214779A (de)
ZA (1) ZA86174B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205640B (it) * 1983-04-06 1989-03-23 Yason Srl Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
JPH0655730B2 (ja) * 1987-07-17 1994-07-27 ザ ヌトラスウィート カンパニー 強力甘味剤
US4900740A (en) * 1987-10-02 1990-02-13 The Nutrasweet Company N,N'-disubstituted guanidines containing a carboxyl or a tetrazolyl moiety
US4870210A (en) * 1987-12-18 1989-09-26 American Home Products Corporation Aminoguanidine derivative as anti-inflammatory agents
IN172842B (de) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
JP2527859Y2 (ja) * 1991-05-14 1997-03-05 ナショナル住宅産業株式会社 切削装置
US5565216A (en) * 1993-07-21 1996-10-15 Carson Products Company Hair relaxer compositions
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
ES2248894T3 (es) * 1997-04-21 2006-03-16 Dainippon Sumitomo Pharma Co., Ltd. Derivados de isoxazol.
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
DE19748696A1 (de) * 1997-11-04 1999-05-06 Basf Ag Verfahren zur Herstellung von substituierten Guanidinderivaten
EP1202718A2 (de) * 1999-07-21 2002-05-08 Kadmus Pharmaceuticals, Inc. Substitutierte guanidinderivate zur behandlung von krebs und schmerz
US6875759B1 (en) 1999-07-21 2005-04-05 Kadmus Pharmaceuticals Substituted guanidines and the use thereof
EP1413302A3 (de) * 1999-07-21 2004-05-12 Kadmus Pharmaceuticals, Inc. Substitutierte Guanidinderivate zur Behandlung von Schmerz
DE10149919A1 (de) * 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
EP2874997A4 (de) 2012-07-19 2016-01-06 Univ Drexel Neue sigma-rezeptorliganden und verfahren zur regulierung der zellulären proteinhomöostase damit
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
US20240246941A1 (en) * 2020-07-15 2024-07-25 St. Jude Children's Research Hospital, Inc. Substituted 4-(3-aminoprop-1-yl)aminoquinoline analogs as modulators of melanoma-associated antigen 11 ubiquitin ligase

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB129443A (en) * 1918-07-11 1919-07-11 Climax Rock Drill & Engineerin Improvements in Valve Gear for Rock Drills and other Percussion Tools.
DE831100C (de) * 1948-10-19 1952-02-11 Farbwerke Hoechst Vormals Meis Verfahren zur Herstellung von Guanylhydrazonen der 4-Aminochinolinreihe
US3474134A (en) * 1960-03-03 1969-10-21 Burroughs Wellcome Co Phenoxyethyl-guanidines and the salts thereof
US3159679A (en) * 1960-12-28 1964-12-01 Union Carbide Corp Oxo recovery process
GB1016071A (en) * 1961-02-15 1966-01-05 Smith Kline French Lab New guanidine derivatives and process for preparing the same
GB972888A (en) * 1961-11-23 1964-10-21 Farmaceutici Italia New 2-amino-(mono- or di-substituted)-ethyl-guanidines
GB1026402A (en) * 1961-12-12 1966-04-20 Wellcome Found Substituted guanidines
US3159676A (en) * 1962-02-07 1964-12-01 Smith Kline French Lab Naphthyl containing guanidines
GB1049285A (en) * 1962-05-14 1966-11-23 Smith Kline French Lab Guanidine and dihydroimidazole derivatives
SE321464B (de) * 1962-08-23 1970-03-09 Pharmacia Ab
US3209023A (en) * 1963-01-02 1965-09-28 Burroughs Wellcome Co Substituted phenoxyethylguanidines
GB1007844A (en) * 1963-08-21 1965-10-22 Pfizer Ltd Guanidine derivatives
US3456058A (en) * 1964-03-03 1969-07-15 Upjohn Co Aralkoxyguanidines,aryloxyalkoxyguanidines and salts thereof in anorectic methods and compositions
US3246031A (en) * 1965-02-23 1966-04-12 Parke Davis & Co Phenoxypropylguanidine compounds
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
US3574744A (en) * 1967-10-26 1971-04-13 Squibb & Sons Inc Guanidinoalkyl derivatives of substituted anilides
ZA694133B (en) * 1968-08-27 1971-01-27 Colgate Palmolive Co Aryloxyalkylguanidines
SE418800B (sv) * 1975-11-13 1981-06-29 Sandoz Ag Forfarande for framstellning av nya antihypertensiva preparat
GB1604674A (en) * 1977-05-17 1981-12-16 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
NZ196923A (en) * 1980-04-29 1983-12-16 Shionogi & Co 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs

Also Published As

Publication number Publication date
DE3664463D1 (en) 1989-08-24
DK10086A (da) 1986-07-11
EP0188333B1 (de) 1989-07-19
US4680300A (en) 1987-07-14
ZA86174B (en) 1987-08-26
DK10086D0 (da) 1986-01-09
AU5216586A (en) 1986-07-17
ES8703410A1 (es) 1987-03-01
JPS61191668A (ja) 1986-08-26
EP0188333A1 (de) 1986-07-23
ES550769A0 (es) 1987-03-01
NZ214779A (en) 1989-08-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee