ZA858040B - Peptides - Google Patents

Peptides

Info

Publication number
ZA858040B
ZA858040B ZA858040A ZA858040A ZA858040B ZA 858040 B ZA858040 B ZA 858040B ZA 858040 A ZA858040 A ZA 858040A ZA 858040 A ZA858040 A ZA 858040A ZA 858040 B ZA858040 B ZA 858040B
Authority
ZA
South Africa
Prior art keywords
atoms
cycloalkyl
alkyl
peptides
cph2p
Prior art date
Application number
ZA858040A
Other languages
English (en)
Inventor
Guenter Hoelzemann
Peter Raddatz
Alfred Jonczyk
Claus J Schmitges
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA858040B publication Critical patent/ZA858040B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA858040A 1984-10-20 1985-10-18 Peptides ZA858040B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438545 DE3438545A1 (de) 1984-10-20 1984-10-20 Peptide

Publications (1)

Publication Number Publication Date
ZA858040B true ZA858040B (en) 1986-06-25

Family

ID=6248412

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA858040A ZA858040B (en) 1984-10-20 1985-10-18 Peptides

Country Status (10)

Country Link
US (1) US4709010A (fr)
EP (1) EP0179352B1 (fr)
JP (1) JPS61100594A (fr)
AT (1) ATE84042T1 (fr)
AU (1) AU586647B2 (fr)
CA (1) CA1276399C (fr)
DE (2) DE3438545A1 (fr)
ES (1) ES8801838A1 (fr)
HU (1) HU196609B (fr)
ZA (1) ZA858040B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3536687A1 (de) * 1985-10-15 1987-04-16 Hoechst Ag Verfahren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
JPH02504143A (ja) * 1987-06-29 1990-11-29 ジ・アップジョン・カンパニー リンゴ酸誘導体含有レニン抑制ペプチド
WO1990005531A1 (fr) * 1988-11-21 1990-05-31 Abbott Laboratories Procede de traitement de maladies vasculaires
US5268164A (en) * 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US9120040B2 (en) * 2011-05-26 2015-09-01 The University Of Akron Anti-fouling materials based on poly(β-peptoid)s

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4609643A (en) * 1980-08-06 1986-09-02 Aktiebolaget Hassle Renin inhibitors, treatments and dipeptide synthesis
CA1258748A (fr) * 1981-10-08 1989-08-22 Daniel F. Veber Peptides inhibiteurs de la renine
CA1245217A (fr) * 1981-12-10 1988-11-22 Joshua S. Boger Peptides inhibiteurs de la renine
US4650661A (en) * 1982-09-15 1987-03-17 Aktiebolaget Hassle Enzyme inhibitors
US4668770A (en) * 1982-12-27 1987-05-26 Merck & Co., Inc. Renin inhibitory tripeptides
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
CA1254699A (fr) * 1984-03-12 1989-05-23 Jasjit S. Bindra Inhibiteurs de la resine contenant de la statine ou ses derives
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
EP0163237A3 (fr) * 1984-05-29 1988-04-27 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
IL78314A0 (en) * 1985-04-03 1986-07-31 Biotechnology Res Ass Expression vectors and methods for the production of recombinant human renin
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
US4665055A (en) * 1985-06-17 1987-05-12 Merck & Co., Inc. Peptide renin inhibitors

Also Published As

Publication number Publication date
ES8801838A1 (es) 1988-02-16
HU196609B (en) 1988-12-28
CA1276399C (fr) 1990-11-13
DE3586936D1 (en) 1993-02-11
ES548014A0 (es) 1988-02-16
AU4891785A (en) 1986-04-24
DE3438545A1 (de) 1986-04-24
EP0179352A2 (fr) 1986-04-30
EP0179352B1 (fr) 1992-12-30
US4709010A (en) 1987-11-24
AU586647B2 (en) 1989-07-20
HUT42504A (en) 1987-07-28
ATE84042T1 (de) 1993-01-15
JPS61100594A (ja) 1986-05-19
EP0179352A3 (en) 1989-04-19

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