ZA85397B - Sulfur-containing 6-ketoprostaglandins - Google Patents
Sulfur-containing 6-ketoprostaglandinsInfo
- Publication number
- ZA85397B ZA85397B ZA85397A ZA85397A ZA85397B ZA 85397 B ZA85397 B ZA 85397B ZA 85397 A ZA85397 A ZA 85397A ZA 85397 A ZA85397 A ZA 85397A ZA 85397 B ZA85397 B ZA 85397B
- Authority
- ZA
- South Africa
- Prior art keywords
- atoms
- alkyl
- substituted
- bond
- effects
- Prior art date
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 22
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 R1 is H Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843401542 DE3401542A1 (de) | 1984-01-18 | 1984-01-18 | Schwefelhaltige 6-ketoprostaglandine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA85397B true ZA85397B (en) | 1985-09-25 |
Family
ID=6225229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA85397A ZA85397B (en) | 1984-01-18 | 1985-01-17 | Sulfur-containing 6-ketoprostaglandins |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4680288A (fr) |
| EP (1) | EP0150461B1 (fr) |
| JP (1) | JPS60161967A (fr) |
| AT (1) | ATE33248T1 (fr) |
| AU (1) | AU570532B2 (fr) |
| CA (1) | CA1251788A (fr) |
| DE (2) | DE3401542A1 (fr) |
| ES (1) | ES8607225A1 (fr) |
| HU (1) | HU192661B (fr) |
| IE (1) | IE850109L (fr) |
| ZA (1) | ZA85397B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3569728D1 (en) * | 1984-03-05 | 1989-06-01 | Teijin Ltd | 7-thiaprostaglandin e 1?'s and process for their preparation |
| DE3533576A1 (de) * | 1985-09-20 | 1987-03-26 | Merck Patent Gmbh | Cyclopentanderivate |
| DE3620442A1 (de) * | 1986-06-18 | 1987-12-23 | Merck Patent Gmbh | Ketolactone |
| CA2027814C (fr) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Traitement d'une maladie hepatobiliaire a base de composes 5-cetoprostaglandin |
| US5256696A (en) * | 1989-11-22 | 1993-10-26 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds |
| US5254588A (en) * | 1989-11-22 | 1993-10-19 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds |
| GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| JP2005521726A (ja) * | 2002-03-27 | 2005-07-21 | チャーターハウス セラピューティックス リミテッド | 医薬化合物における改良 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH613189A5 (fr) * | 1972-11-17 | 1979-09-14 | Merck Patent Gmbh | |
| DE2422924A1 (de) * | 1974-05-11 | 1975-11-27 | Merck Patent Gmbh | Thiaprostaglandine |
| DE2550004C2 (de) * | 1975-11-07 | 1984-04-26 | Merck Patent Gmbh, 6100 Darmstadt | Thiaprostaglandine sowie Verfahren zu ihrer Herstellung |
| DE2644972C2 (de) * | 1976-10-06 | 1986-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Thiaprostansäurederivate, deren Herstellung und diese Verbindungen enthaltende Mittel |
| US4205178A (en) * | 1976-12-30 | 1980-05-27 | The Upjohn Company | 6-Keto prostaglandin E-type compounds |
| JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| DE2913856A1 (de) * | 1979-04-06 | 1980-10-23 | Hoechst Ag | Neue prostaglandinderivate in der 6-keto-pge tief 1 -reihe |
| DE2946116A1 (de) * | 1979-11-15 | 1981-05-27 | Hoechst Ag, 6000 Frankfurt | Neue prostaglandinderivate in der 6-keto-pga(pfeil abwaerts)1 -reihe(pfeil abwaerts) |
-
1984
- 1984-01-18 DE DE19843401542 patent/DE3401542A1/de not_active Withdrawn
- 1984-12-20 DE DE8484116000T patent/DE3470159D1/de not_active Expired
- 1984-12-20 EP EP84116000A patent/EP0150461B1/fr not_active Expired
- 1984-12-20 AT AT84116000T patent/ATE33248T1/de not_active IP Right Cessation
-
1985
- 1985-01-16 CA CA000472165A patent/CA1251788A/fr not_active Expired
- 1985-01-17 ZA ZA85397A patent/ZA85397B/xx unknown
- 1985-01-17 HU HU85200A patent/HU192661B/hu not_active IP Right Cessation
- 1985-01-17 ES ES539648A patent/ES8607225A1/es not_active Expired
- 1985-01-17 AU AU37766/85A patent/AU570532B2/en not_active Ceased
- 1985-01-17 IE IE850109A patent/IE850109L/xx unknown
- 1985-01-18 US US06/692,490 patent/US4680288A/en not_active Expired - Fee Related
- 1985-01-18 JP JP60006057A patent/JPS60161967A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0150461A2 (fr) | 1985-08-07 |
| ATE33248T1 (de) | 1988-04-15 |
| EP0150461A3 (en) | 1985-08-21 |
| HU192661B (en) | 1987-06-29 |
| EP0150461B1 (fr) | 1988-03-30 |
| CA1251788A (fr) | 1989-03-28 |
| IE850109L (en) | 1985-07-18 |
| DE3401542A1 (de) | 1985-08-01 |
| ES539648A0 (es) | 1986-05-16 |
| JPS60161967A (ja) | 1985-08-23 |
| AU570532B2 (en) | 1988-03-17 |
| HUT39156A (en) | 1986-08-28 |
| AU3776685A (en) | 1985-07-25 |
| DE3470159D1 (en) | 1988-05-05 |
| ES8607225A1 (es) | 1986-05-16 |
| US4680288A (en) | 1987-07-14 |
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